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| PID | QueryLength | FocusSite | TITLE |
| 2752856 | 925 | 373 E | RecName: Full=Antiviral innate immune response receptor RIG-I ;AltName: Full=ATP-dependent RNA helicase DDX58 ; EC=3.6.4.13 ;AltName: Full=DEAD box protein 58;AltName: Full=RIG-I-like receptor 1; Short=RLR-1;AltName: Full=RNA sensor RIG-I ;AltName: Full=Retinoic acid-inducible gene 1 protein; Short=RIG-1;AltName: Full=Retinoic acid-inducible gene I protein; Short=RIG-I; |
| AC/ID | AC:O95786 ID:RIGI_HUMAN |
| Feature Table for 373-th site |
VARIANT: /note="E -> A (in SGMRT2; results in constitutive activation and enhanced interferon-mediated signaling; dbSNP:rs786204847)" /id="VAR_073668" MOTIF: /note="DECH box" MUTAGEN: /note="DECH->AACA: Loss of dsRNA-induced ATPase activity. No effect on ds-RNA binding. Changed RIG-I signaling pathway." DOMAIN: /note="Helicase ATP-binding" REGION: /note="Interaction with ZC3HAV1" CHAIN: /note="Antiviral innate immune response receptor RIG-I" /id="PRO_0000144093" |
| VARIANT for 373-th site |
E->A LP/P dbSNP:rs7862048 " Singleton-Merten syndrome 2 (SGMRT2) " [MIM:616298] |
Percentages of Amino Acids in Homologous Proteins
 [show alignment]
|
E:100% |
| Template For Monomer | predicted SecStr | predicted ExpBur | Predicted Relative Acc(%) |
 8dvs |
T (Hbond turn) | b (buried) | 12.1 |
| Predicted Bind Molecules |
| homo:2 metal:5 precipitant:4 |
| Templates for 3D complexes |
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homo [94569:DDX58_HUMAN
] 4on9_A_1_B_1 4on9_B_1_A_1
metal [MG ] 7jl3_A_1_K_1 7jl3_C_1_O_1 7jl3_E_1_S_1 7to2_A_1_D_1 8dvs_A_1_D_1
precipitant [BEF ] 5e3h_A_1_J_1 [ALF ] 7jl3_A_1_J_1 7jl3_C_1_N_1 7jl3_E_1_R_1
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Summary for the 373-rd Site(E)