Summary for the 280-th Site(D) |
PID | QueryLength | FocusSite | TITLE |
2692367 | 631 | 280 D | RecName: Full=Sphingomyelin phosphodiesterase ; EC=3.1.4.12 ; EC=3.1.4.3 ;AltName: Full=Acid sphingomyelinase ; Short=aSMase;Contains: RecName: Full=Sphingomyelin phosphodiesterase, processed form ;Flags: Precursor; |
AC/ID | AC:P17405 ID:ASM_HUMAN |
Feature Table for 280-th site |
BINDING: /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" BINDING: /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" VARIANT: /note="D -> A (in NPDA; strongly reduces enzyme activity; intermediate form with clinical features of both Niemann- Pick disease types A and B)" /id="VAR_060890" CHAIN: /note="Sphingomyelin phosphodiesterase, processed form" /id="PRO_0000456684" CHAIN: /note="Sphingomyelin phosphodiesterase" /id="PRO_0000002323" |
VARIANT for 280-th site |
D->A LP/P " Niemann-Pick disease A (NPDA) " [MIM:257200] |
Percentages of Amino Acids in Homologous Proteins [show alignment] |
D:100% |
Template For Monomer | predicted SecStr | predicted ExpBur | Predicted Relative Acc(%) |
5jg8 | (coil) | b (buried) | 0.6 |
Predicted Bind Molecules |
compound:6 metal:42 precipitant:8 |
Templates for 3D complexes |
compound [NT8 ] 5fi9_A_1_N_1 5fi9_B_1_Q_1 [PC ] 5i85_A_1_U_1 5i85_A_2_U_2 5i85_A_3_U_3 5i85_A_4_U_4 metal [ZN ] 5fi9_A_1_L_1 5fi9_A_1_M_1 5fi9_B_1_O_1 5fi9_B_1_P_1 5fib_A_1_K_1 5fib_A_1_L_1 5fib_B_1_X_1 5fib_B_1_Y_1 5fic_A_1_K_1 5fic_A_1_L_1 5fic_B_1_S_1 5fic_B_1_T_1 5fic_C_1_Y_1 5fic_C_1_Z_1 5fic_D_1_DA_1 5fic_D_1_EA_1 5hqn_A_1_I_1 5hqn_A_1_J_1 5hqn_B_1_L_1 5hqn_B_1_M_1 5i81_A_1_L_1 5i81_A_2_L_2 5i81_A_1_M_1 5i81_A_2_M_2 5i85_A_1_H_1 5i85_A_2_H_2 5i85_A_3_H_3 5i85_A_4_H_4 5i85_A_1_I_1 5i85_A_2_I_2 5i85_A_3_I_3 5i85_A_4_I_4 5i8r_A_1_Q_1 5i8r_A_1_R_1 5i8r_B_1_X_1 5i8r_B_1_Y_1 5i8r_C_1_DA_1 5i8r_C_1_EA_1 5jg8_A_1_J_1 5jg8_A_1_K_1 5jg8_B_1_P_1 5jg8_B_1_Q_1 precipitant [PO4 ] 5fic_A_1_M_1 5fic_B_1_V_1 5fic_C_1_BA_1 5fic_D_1_FA_1 5hqn_A_1_K_1 5hqn_B_1_O_1 [ACT ] 5jg8_A_1_L_1 5jg8_B_1_R_1 |
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