Summary for the 579-th Site(G)
PID QueryLength FocusSite TITLE
2692367 631 579 G RecName: Full=Sphingomyelin phosphodiesterase ; EC=3.1.4.12 ; EC=3.1.4.3 ;AltName: Full=Acid sphingomyelinase ; Short=aSMase;Contains: RecName: Full=Sphingomyelin phosphodiesterase, processed form ;Flags: Precursor;
UniProt Information
AC/IDAC:P17405 ID:ASM_HUMAN
Feature Table for 579-th site VARIANT: /note="G -> S (in NPDA; impairs enzyme activity; also in patients with an intermediate form; dbSNP:rs120074119)" ECO:0000269|PubMed:1718266" /id="VAR_005067"
TURN:
CHAIN: /note="Sphingomyelin phosphodiesterase, processed form" /id="PRO_0000456684"
CHAIN: /note="Sphingomyelin phosphodiesterase" /id="PRO_0000002323"
VARIANT for 579-th site G->S LP/P dbSNP:rs1200741 " Niemann-Pick disease A (NPDA) " [MIM:257200]
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
S:29% V:22% N:17% G:14% R:9% A:8%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
5jg8 T (Hbond turn) e (exposed) 20.2
3D Complex Information
Predicted Bind Molecules
otherpoly:13 compound:3 precipitant:1
Templates for 3D complexes
otherpoly [2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ] 5fi9_A_1_E_1 5fic_B_1_G_1 5fic_C_1_H_1 5hqn_A_1_E_1 5hqn_B_1_H_1 5i85_A_1_D_1 5i85_A_2_D_2 5i85_A_3_D_3 5i85_A_4_D_4 [alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ] 5fib_B_1_I_1 [beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ] 5fic_A_1_E_1 5fic_D_1_I_1 [alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ] 5jg8_B_1_F_1 compound [NAG ] 5i81_A_1_J_1 5i81_A_2_J_2 5i8r_A_1_N_1 precipitant [SO4 ] 5fib_B_1_CA_1


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