Summary for the 510-th Site(S) |
PID | QueryLength | FocusSite | TITLE |
2692367 | 631 | 510 S | RecName: Full=Sphingomyelin phosphodiesterase ; EC=3.1.4.12 ; EC=3.1.4.3 ;AltName: Full=Acid sphingomyelinase ; Short=aSMase;Contains: RecName: Full=Sphingomyelin phosphodiesterase, processed form ;Flags: Precursor; |
AC/ID | AC:P17405 ID:ASM_HUMAN |
Feature Table for 510-th site |
MOD_RES: /note="Phosphoserine; by PKC/PRKCD" VARIANT: /note="S -> F (in dbSNP:rs200652683)" /id="VAR_077323" MUTAGEN: /note="S->A: Abolishes constitutive secretion and decreases secretion in response to IL1B. No effect on lysosomal targeting. No effect on sphingomyelin phosphodiesterase activity. No effect on endolysosome location. Abolishes phosphorylation by PRKCD." ECO:0000269|PubMed:20807762" CHAIN: /note="Sphingomyelin phosphodiesterase, processed form" /id="PRO_0000456684" CHAIN: /note="Sphingomyelin phosphodiesterase" /id="PRO_0000002323" |
VARIANT for 510-th site |
S->F LB/B dbSNP:rs2006526 " -" |
Percentages of Amino Acids in Homologous Proteins [show alignment] |
T:39% S:29% D:16% K:8% A:1% R:1% N:1% E:1% G:1% I:1% L:1% P:1% V:1% |
Template For Monomer | predicted SecStr | predicted ExpBur | Predicted Relative Acc(%) |
5jg8 | (coil) | b (buried) | 6.2 |
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