Summary for the 522-nd Site(N)
PID QueryLength FocusSite TITLE
2692367 631 522 N RecName: Full=Sphingomyelin phosphodiesterase ; EC=3.1.4.12 ; EC=3.1.4.3 ;AltName: Full=Acid sphingomyelinase ; Short=aSMase;Contains: RecName: Full=Sphingomyelin phosphodiesterase, processed form ;Flags: Precursor;
UniProt Information
AC/IDAC:P17405 ID:ASM_HUMAN
Feature Table for 522-th site CARBOHYD: /note="N-linked (GlcNAc...) asparagine" ECO:0000269|PubMed:27349982, ECO:0000269|PubMed:9030779, ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8"
VARIANT: /note="N -> S (in NPDB)" /id="VAR_068440"
MUTAGEN: /note="N->G: Loss of sphingomyelin phosphodiesterase activity. Loss of secretion."
CHAIN: /note="Sphingomyelin phosphodiesterase, processed form" /id="PRO_0000456684"
CHAIN: /note="Sphingomyelin phosphodiesterase" /id="PRO_0000002323"
VARIANT for 522-th site N->S LP/P " Niemann-Pick disease B (NPDB) " [MIM:607616]
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
N:77% D:23%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
5jg8 (coil) e (exposed) 23.0
3D Complex Information
Predicted Bind Molecules
otherpoly:28 compound:9
Templates for 3D complexes
otherpoly [alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ] 5fc1_A_1_D_1 5fc5_A_1_D_1 5fc6_A_1_D_1 5fca_A_1_E_1 5fca_B_1_I_1 5fcb_A_1_D_1 5fib_B_1_I_1 [2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ] 5fc7_A_1_D_1 5fi9_A_1_E_1 5fi9_B_1_J_1 5fib_A_1_F_1 5fic_B_1_G_1 5fic_C_1_H_1 5hqn_A_1_E_1 5hqn_B_1_H_1 5i85_A_1_D_1 5i85_A_2_D_2 5i85_A_3_D_3 5i85_A_4_D_4 5i8r_C_1_I_1 5jg8_A_1_C_1 8w6p_A_1_E_1 8w6r_A_1_B_1 [beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ] 5fic_A_1_E_1 5fic_D_1_I_1 5i8r_B_1_H_1 8w6p_B_1_F_1 [alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ] 5jg8_B_1_F_1 compound [NAG ] 5ebb_A_1_H_1 5ebb_B_1_N_1 5ebb_C_1_U_1 5ebe_A_1_H_1 5ebe_B_1_N_1 5ebe_C_1_X_1 5i81_A_1_J_1 5i81_A_2_J_2 5i8r_A_1_N_1


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