Summary for the 510-th Site(S)
PID QueryLength FocusSite TITLE
2692367 631 510 S RecName: Full=Sphingomyelin phosphodiesterase ; EC=3.1.4.12 ; EC=3.1.4.3 ;AltName: Full=Acid sphingomyelinase ; Short=aSMase;Contains: RecName: Full=Sphingomyelin phosphodiesterase, processed form ;Flags: Precursor;
UniProt Information
AC/IDAC:P17405 ID:ASM_HUMAN
Feature Table for 510-th site MOD_RES: /note="Phosphoserine; by PKC/PRKCD"
VARIANT: /note="S -> F (in dbSNP:rs200652683)" /id="VAR_077323"
MUTAGEN: /note="S->A: Abolishes constitutive secretion and decreases secretion in response to IL1B. No effect on lysosomal targeting. No effect on sphingomyelin phosphodiesterase activity. No effect on endolysosome location. Abolishes phosphorylation by PRKCD." ECO:0000269|PubMed:20807762"
CHAIN: /note="Sphingomyelin phosphodiesterase, processed form" /id="PRO_0000456684"
CHAIN: /note="Sphingomyelin phosphodiesterase" /id="PRO_0000002323"
VARIANT for 510-th site S->F LB/B dbSNP:rs2006526 " -"
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
T:39% S:29% D:16% K:8% A:1% R:1% N:1% E:1% G:1% I:1% L:1% P:1% V:1%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
5jg8 (coil) b (buried) 6.2


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