Summary for the 427-th Site(H)
PID QueryLength FocusSite TITLE
2692367 631 427 H RecName: Full=Sphingomyelin phosphodiesterase ; EC=3.1.4.12 ; EC=3.1.4.3 ;AltName: Full=Acid sphingomyelinase ; Short=aSMase;Contains: RecName: Full=Sphingomyelin phosphodiesterase, processed form ;Flags: Precursor;
UniProt Information
AC/IDAC:P17405 ID:ASM_HUMAN
Feature Table for 427-th site BINDING: /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8"
VARIANT: /note="H -> R (in NPDB; results in loss of activity; the patient also carries mutation H-228 that has sufficient activity to account for the Niemann-Pick disease type B phenotype; dbSNP:rs794727629)" /id="VAR_068438"
CHAIN: /note="Sphingomyelin phosphodiesterase, processed form" /id="PRO_0000456684"
CHAIN: /note="Sphingomyelin phosphodiesterase" /id="PRO_0000002323"
VARIANT for 427-th site H->R LP/P dbSNP:rs7947276 " Niemann-Pick disease B (NPDB) " [MIM:607616]
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
H:100%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
5jg8 S (bend) b (buried) 0.0
3D Complex Information
Predicted Bind Molecules
compound:4 metal:11 precipitant:1
Templates for 3D complexes
compound [PC ] 5i85_A_1_U_1 5i85_A_2_U_2 5i85_A_3_U_3 5i85_A_4_U_4 metal [ZN ] 5i81_A_1_L_1 5i81_A_2_L_2 5i85_A_1_H_1 5i85_A_2_H_2 5i85_A_3_H_3 5i85_A_4_H_4 5i8r_A_1_Q_1 5i8r_B_1_X_1 5i8r_C_1_DA_1 5jg8_A_1_K_1 5jg8_B_1_Q_1 precipitant [ACT ] 5jg8_B_1_R_1


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