Summary for the 129-th Site(L)
PID QueryLength FocusSite TITLE
2691701 207 129 L RecName: Full=Ras-related protein Rab-7a ; EC=3.6.5.2 ;
UniProt Information
AC/IDAC:P51149 ID:RAB7A_HUMAN
Feature Table for 129-th site VARIANT: /note="L -> F (in CMT2B; increases GTP hydrolysis; decreases affinity for GTP and GDP; does not affect interaction with NTRK1; results in higher levels of NTRK1 and MAPK1/MAPK3 phosphorylation after NGF stimulation consistent with enhanced MAPK signaling; increases interaction with PRPH; dbSNP:rs121909078)" ECO:0000269|PubMed:20028791, ECO:0000269|PubMed:21151572, ECO:0000269|PubMed:23179371" /id="VAR_018722"
STRAND:
CHAIN: /note="Ras-related protein Rab-7a" /id="PRO_0000121121"
VARIANT for 129-th site L->F LP/P dbSNP:rs1219090 " Charcot-Marie-Tooth disease, axonal, 2B (CMT2B) " [MIM:600882]
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
L:65% M:7% I:6% V:5% K:4% A:3% R:2% D:1% C:1% Q:1% E:1% H:1% F:1% P:1% S:1% T:1%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
1vg8 S (bend) e (exposed) 44.4
3D Complex Information
Predicted Bind Molecules
compound:28
Templates for 3D complexes
compound [GTP ] 1t91_A_1_F_1 1t91_B_1_H_1 1t91_C_1_J_1 1t91_D_1_L_1 1yhn_A_1_D_1 1yhn_A_2_D_2 5z2m_B_1_F_1 5z2m_C_1_G_1 6iyb_A_1_F_1 6iyb_C_1_H_1 6wcw_A_1_C_1 7f6j_A_1_E_1 7f6j_B_1_G_1 [GDP ] 1vg0_B_1_F_1 1vg1_A_1_C_1 1vg9_B_1_K_1 1vg9_D_1_O_1 1vg9_F_1_S_1 1vg9_H_1_W_1 [GNP ] 1vg8_A_1_F_1 1vg8_B_1_H_1 1vg8_C_1_J_1 1vg8_D_1_L_1 3law_A_1_G_1 3law_B_1_I_1 3law_C_1_K_1 3law_D_1_M_1 3law_E_1_O_1


[Back to SiteTable]
[Back to Search Page]
[Back to Top Page]