Summary for the 157-th Site(K)
PID QueryLength FocusSite TITLE
2691701 207 157 K RecName: Full=Ras-related protein Rab-7a ; EC=3.6.5.2 ;
UniProt Information
AC/IDAC:P51149 ID:RAB7A_HUMAN
Feature Table for 157-th site VARIANT: /note="K -> N (in CMT2B; does not affect interaction with NTRK1; results in higher levels of NTRK1 and MAPK1/MAPK3 phosphorylation after NGF stimulation consistent with enhanced MAPK signaling; increases interaction with PRPH; dbSNP:rs121909081)" ECO:0000269|PubMed:21151572, ECO:0000269|PubMed:23179371" /id="VAR_037887"
BINDING: /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" ECO:0000269|PubMed:20028791"
TURN:
CHAIN: /note="Ras-related protein Rab-7a" /id="PRO_0000121121"
VARIANT for 157-th site K->N LP/P dbSNP:rs1219090 " Charcot-Marie-Tooth disease, axonal, 2B (CMT2B) " [MIM:600882]
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
K:65% L:12% A:5% R:5% T:5% M:2% S:2% Q:1% E:1% I:1% F:1% V:1%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
1vg8 T (Hbond turn) e (exposed) 41.0
3D Complex Information
Predicted Bind Molecules
compound:47
Templates for 3D complexes
compound [GNP ] 1ky2_A_1_C_1 1vg8_A_1_F_1 1vg8_B_1_H_1 1vg8_C_1_J_1 1vg8_D_1_L_1 1yzl_A_1_C_1 2ocb_A_1_C_1 3law_A_1_G_1 3law_B_1_I_1 3law_C_1_K_1 3law_D_1_M_1 3law_E_1_O_1 [GDP ] 1ky3_A_1_C_1 1s8f_A_1_D_1 1s8f_A_2_D_2 1s8f_B_1_K_1 1s8f_B_2_K_2 1vg0_B_1_F_1 1vg1_A_1_C_1 1vg9_B_1_K_1 1vg9_D_1_O_1 1vg9_F_1_S_1 1vg9_H_1_W_1 1wms_A_1_C_1 1wms_B_1_D_1 [GTP ] 1t91_A_1_F_1 1t91_B_1_H_1 1t91_C_1_J_1 1t91_D_1_L_1 1yhn_A_1_D_1 1yhn_A_2_D_2 4qxa_A_1_C_1 5z2m_B_1_F_1 5z2m_C_1_G_1 6iyb_A_1_F_1 6iyb_C_1_H_1 6wcw_A_1_C_1 7e1t_A_1_F_1 7e1t_B_1_H_1 7f6j_A_1_E_1 7f6j_B_1_G_1 [2UH ] 4phf_A_1_B_1 [2UJ ] 4phg_A_1_C_1 [2UK ] 4phh_A_1_E_1 4phh_B_1_H_1 4phh_C_1_K_1 4phh_D_1_M_1


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