Summary for the 22-nd Site(T)
PID QueryLength FocusSite TITLE
2691701 207 22 T RecName: Full=Ras-related protein Rab-7a ; EC=3.6.5.2 ;
UniProt Information
AC/IDAC:P51149 ID:RAB7A_HUMAN
Feature Table for 22-th site MUTAGEN: /note="T->N: Abolishes localization on late endosomes, lysosomes and phagosomes and reduces phagosomal fusions. Abolishes association of RILP with the phagosomes. No loss of interaction with CLN5. No loss of interaction with PRPH. Reduced interaction with VPS13A. Inhibits SARS-CoV-2 infection." ECO:0000269|PubMed:22431521, ECO:0000269|PubMed:23179371, ECO:0000269|PubMed:30709847, ECO:0000269|PubMed:34159616"
BINDING: /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" ECO:0000269|PubMed:20028791"
HELIX:
CHAIN: /note="Ras-related protein Rab-7a" /id="PRO_0000121121"
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
T:53% S:44% G:1% L:1% K:1%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
1vg8 H (alpha-helix) e (exposed) 26.6
3D Complex Information
Predicted Bind Molecules
hetero:10 homo:14 compound:336 metal:292 precipitant:21
Templates for 3D complexes
hetero [65303:Q9LT31_ARATH ] 2efc_B_1_A_1 2efc_D_1_C_1 2efd_B_1_A_1 2efd_D_1_C_1 2efe_B_1_A_1 2efe_D_1_C_1 2efh_B_1_A_1 2efh_D_1_C_1 4g01_B_1_A_1 [66399:RABX5_HUMAN ] 4q9u_B_1_A_1 homo [44527:RAB9A_CANFA ] 1s8f_A_1_B_1 1s8f_A_2_B_2 1s8f_B_1_A_1 1s8f_B_2_A_2 [42780:RAB5A_HUMAN ] 1tu4_D_1_C_2 1tu4_D_2_C_1 [48904:RB27B_HUMAN ] 2f7s_A_1_B_1 2f7s_B_1_A_1 2iez_A_1_B_1 2iez_B_1_A_1 2iez_D_1_C_1 2if0_A_1_B_1 2if0_B_1_A_1 [54522:RB27B_MOUSE ] 2iez_C_1_D_1 compound [GNP ] 1ek0_A_1_D_1 1huq_A_1_C_1 1ky2_A_1_C_1 1n6h_A_1_C_1 1n6n_A_1_C_1 1n6o_A_1_C_1 1n6p_A_1_C_1 1n6r_A_1_C_1 1r2q_A_1_C_1 1tu3_A_1_L_1 1tu3_B_1_N_1 1tu3_C_1_P_1 1tu3_D_1_R_1 1tu3_E_1_T_1 1tu3_E_2_T_2 1u8y_A_1_E_1 1u8y_B_1_H_1 1uad_A_1_F_1 1uad_B_1_H_1 1vg8_A_1_F_1 1vg8_B_1_H_1 1vg8_C_1_J_1 1vg8_D_1_L_1 1x3s_A_1_C_1 1yvd_A_1_C_1 1yzk_A_1_C_1 1yzl_A_1_C_1 1z06_A_1_C_1 1z07_A_1_C_1 2ew1_A_1_C_1 2f9m_A_1_E_1 2fg5_A_1_C_1 2ocb_A_1_C_1 2y8e_A_1_D_1 2y8e_B_1_H_1 3law_A_1_G_1 3law_B_1_I_1 3law_C_1_K_1 3law_D_1_M_1 3law_E_1_O_1 3nkv_A_1_C_1 3qbt_A_1_J_1 3qbt_B_1_L_1 3qbt_C_1_N_1 3qbt_D_1_P_1 3tnf_A_1_D_1 4c4p_A_1_C_1 4kyi_B_1_M_1 4kyi_D_1_Q_1 4kyi_F_1_U_1 4kyi_H_1_X_1 4lhw_A_1_G_1 4lhw_B_1_J_1 4lhw_C_1_L_1 4lhw_D_1_N_1 4lhw_E_1_P_1 4uj3_A_1_Y_1 4uj3_D_1_AA_1 4uj3_G_1_CA_1 4uj3_J_1_EA_1 4uj3_M_1_GA_1 4uj3_P_1_JA_1 4uj3_S_1_LA_1 4uj3_V_1_NA_1 4uj4_A_1_M_1 4uj4_A_2_M_2 4uj4_D_1_O_1 4uj4_G_1_Q_1 4uj4_J_1_S_1 4uj4_J_3_S_3 4uj5_A_1_E_1 4uj5_B_1_H_1 5szh_B_1_C_1 5szi_A_1_C_1 5szk_B_1_D_1 5xr6_A_1_C_1 5xr6_B_1_E_1 6huf_A_1_R_1 6huf_B_1_T_1 6huf_C_1_V_1 6huf_D_1_X_1 6huf_E_1_Z_1 6huf_F_1_BA_1 6huf_G_1_DA_1 6huf_H_1_FA_1 6huf_I_1_HA_1 6huf_J_1_JA_1 6huf_K_1_LA_1 6huf_L_1_NA_1 6huf_M_1_PA_1 6huf_N_1_RA_1 6huf_O_1_TA_1 6huf_P_1_VA_1 6stg_A_1_C_1 6stg_B_1_E_1 6yx5_A_1_D_1 6zsi_A_1_E_1 6zsi_B_1_H_1 6zsj_A_1_E_1 6zsj_B_1_G_1 7opp_A_1_C_1 7opp_B_1_E_1 7opq_A_1_D_1 7opq_B_1_M_1 7opr_A_1_C_1 7opr_B_1_M_1 [GDP ] 1ky3_A_1_C_1 1n6i_A_1_C_1 1n6k_A_1_C_1 1oiv_A_1_C_1 1oiv_B_1_F_1 1oix_A_1_B_1 1s8f_A_1_D_1 1s8f_A_2_D_2 1s8f_B_1_K_1 1s8f_B_2_K_2 1tu4_A_1_F_1 1tu4_A_2_F_2 1tu4_B_1_K_1 1tu4_B_2_K_2 1tu4_C_1_M_1 1tu4_C_2_M_2 1tu4_D_1_T_1 1tu4_D_2_T_2 1u90_A_1_D_1 1u90_B_1_F_1 1vg0_B_1_F_1 1vg1_A_1_C_1 1vg9_B_1_K_1 1vg9_D_1_O_1 1vg9_F_1_S_1 1vg9_H_1_W_1 1wms_A_1_C_1 1wms_B_1_D_1 1z0a_A_1_F_1 1z0a_B_1_H_1 1z0a_C_1_J_1 1z0a_D_1_L_1 1z0d_A_1_E_1 1z0d_B_1_G_1 1z0f_A_1_C_1 2a5j_A_1_C_1 2a78_A_1_D_1 2a9k_A_1_D_1 2bov_A_1_C_1 2efc_B_1_E_1 2efc_D_1_F_1 2efh_B_1_E_1 2efh_D_1_F_1 2f7s_A_1_D_1 2f7s_B_1_F_1 2f9l_A_1_C_1 2g77_B_1_D_1 2hei_A_1_C_1 2hei_B_1_E_1 2iey_B_1_D_1 2iey_B_2_D_2 2iez_A_1_F_1 2iez_B_1_H_1 2iez_C_1_J_1 2iez_D_1_L_1 2if0_A_1_D_1 2if0_B_1_F_1 2rhd_A_1_E_1 3sfv_A_1_C_1 4djt_A_1_C_1 4fmb_B_1_H_1 4fmb_B_2_H_2 4fmb_D_1_K_1 4fmb_D_2_K_2 4fmb_F_1_N_1 4fmb_F_2_N_2 4fmc_B_1_I_1 4fmc_D_1_L_1 4fmd_B_1_H_1 4fmd_D_1_L_1 4fmd_F_1_P_1 4fme_B_1_H_1 4fme_E_1_M_1 4g01_B_1_D_1 4hlq_B_1_M_1 4hlq_D_1_Q_1 4hlq_F_1_V_1 4hlq_H_1_Y_1 4hlq_J_1_CA_1 4i1o_A_1_J_1 4i1o_C_1_N_1 4i1o_E_1_U_1 4i1o_G_1_X_1 4iru_B_1_T_1 4iru_D_1_IA_1 4iru_F_1_NA_1 4jvs_B_1_D_1 4lhv_A_1_F_1 4lhv_B_1_H_1 4lhv_C_1_J_1 4lhv_D_1_L_1 4lhv_E_1_N_1 4lhy_A_1_G_1 4lhy_B_1_H_1 4li0_A_1_G_1 4li0_B_1_H_1 4lwz_A_1_E_1 4lwz_C_1_G_1 4lx0_A_1_G_1 4lx0_C_1_K_1 4ojk_A_1_E_1 4ojk_B_1_F_1 4ojk_B_2_F_2 5c4g_A_1_D_1 5euq_A_1_C_1 5fbq_B_1_D_1 5jcz_A_1_H_1 5jcz_D_1_Y_1 5jcz_F_1_FA_1 5o74_F_1_O_1 5o74_J_1_Q_1 5o74_L_1_R_1 5xr4_A_1_D_1 5xr4_B_1_H_1 6iy1_A_1_G_1 6iy1_B_1_H_1 6iy1_C_1_I_1 6iy1_D_1_J_1 6iy1_E_1_K_1 6iy1_F_1_L_1 6l6o_A_1_B_1 6o62_A_1_B_1 6o62_A_2_B_2 6p0i_A_1_B_1 6p0j_A_1_B_1 6p0k_A_1_E_1 6p0l_A_1_D_1 6p0m_A_1_E_1 6p0n_A_1_F_1 6p0o_A_1_B_1 6sku_B_1_C_1 6stf_A_1_F_1 6stf_D_1_L_1 6stf_E_1_N_1 6zay_A_1_K_1 6zay_C_1_W_1 7bwt_B_1_J_1 7ezb_A_1_C_1 7ezb_B_1_E_1 8fjh_A_1_B_1 8fji_A_1_B_1 [GTP ] 1n6l_A_1_C_1 1t91_A_1_F_1 1t91_B_1_H_1 1t91_C_1_J_1 1t91_D_1_L_1 1yhn_A_1_D_1 1yhn_A_2_D_2 1z0j_A_1_D_1 2d7c_A_1_F_1 2d7c_B_1_I_1 2gil_A_1_F_1 2gil_B_1_H_1 2gil_C_1_J_1 2gil_D_1_L_1 2gzd_A_1_F_1 2gzd_B_1_H_1 2gzh_A_1_F_1 2gzh_A_2_F_2 2hv8_A_1_I_1 2hv8_A_2_I_2 2hv8_C_1_N_1 2hv8_E_1_S_1 2zet_A_1_F_1 2zet_C_1_K_1 3mjh_A_1_E_1 3mjh_C_1_H_1 3tkl_A_1_D_1 4d0g_A_1_C_1 4lhz_A_1_G_1 4lhz_B_1_H_1 4qxa_A_1_C_1 5ez5_A_1_D_1 5ez5_B_1_F_1 5ez5_B_2_F_2 5lef_B_1_I_1 5xr7_A_1_C_1 5xr7_B_1_E_1 5z2m_B_1_F_1 5z2m_C_1_G_1 6iyb_A_1_F_1 6iyb_C_1_H_1 6rir_A_1_E_1 6rir_B_1_H_1 6sq2_A_1_E_1 6sq2_B_1_G_1 6sur_D_1_T_1 6wcw_A_1_C_1 6whe_A_1_C_1 6whe_B_1_E_1 6y09_A_1_F_1 6y09_C_1_M_1 7bl1_F_1_G_1 7e1t_A_1_F_1 7e1t_B_1_H_1 7f6j_A_1_E_1 7f6j_B_1_G_1 7lwb_A_1_C_1 7lwb_A_2_C_2 [GSP ] 1oiw_A_1_B_1 4d0l_B_1_H_1 4d0l_D_1_K_1 4d0l_F_1_N_1 4d0m_B_1_LA_1 4d0m_D_1_OA_1 4d0m_DA_1_PB_1 4d0m_H_1_RA_1 4d0m_HA_1_SB_1 4d0m_J_1_UA_1 4d0m_N_1_XA_1 4d0m_P_1_AB_1 4d0m_R_1_DB_1 4d0m_T_1_GB_1 4d0m_X_1_JB_1 4d0m_Z_1_MB_1 5c46_B_1_E_1 5fbl_B_1_D_1 5fbr_B_1_D_1 5fbv_B_1_D_1 5fbw_B_1_D_1 7ezd_B_1_D_1 7eze_B_1_E_1 [GNH ] 2efe_B_1_E_1 2efe_D_1_F_1 [2UH ] 4phf_A_1_B_1 [2UJ ] 4phg_A_1_C_1 [2UK ] 4phh_A_1_E_1 4phh_B_1_H_1 4phh_C_1_K_1 4phh_D_1_M_1 metal [MG ] 1ek0_A_1_B_1 1huq_A_1_B_1 1ky2_A_1_B_1 1ky3_A_1_B_1 1n6h_A_1_B_1 1n6i_A_1_B_1 1n6k_A_1_B_1 1n6l_A_1_B_1 1n6n_A_1_B_1 1n6o_A_1_B_1 1n6p_A_1_B_1 1n6r_A_1_B_1 1oiw_A_1_C_1 1oix_A_1_D_1 1r2q_A_1_B_1 1s8f_B_1_H_1 1s8f_B_2_H_2 1t91_A_1_E_1 1t91_B_1_G_1 1t91_C_1_I_1 1t91_D_1_K_1 1tu3_A_1_K_1 1tu3_B_1_M_1 1tu3_C_1_O_1 1tu3_D_1_Q_1 1tu3_E_1_S_1 1tu3_E_2_S_2 1u8y_A_1_C_1 1u8y_B_1_F_1 1u90_A_1_C_1 1u90_B_1_E_1 1uad_A_1_E_1 1uad_B_1_G_1 1vg0_B_1_E_1 1vg1_A_1_B_1 1vg8_A_1_E_1 1vg8_B_1_G_1 1vg8_C_1_I_1 1vg8_D_1_K_1 1vg9_B_1_I_1 1vg9_D_1_M_1 1vg9_F_1_Q_1 1vg9_H_1_U_1 1x3s_A_1_B_1 1yhn_A_1_C_1 1yhn_A_2_C_2 1yvd_A_1_B_1 1yzk_A_1_B_1 1yzl_A_1_B_1 1z06_A_1_B_1 1z07_A_1_B_1 1z0a_A_1_E_1 1z0a_B_1_G_1 1z0a_C_1_I_1 1z0a_D_1_K_1 1z0d_A_1_D_1 1z0d_B_1_F_1 1z0f_A_1_B_1 1z0j_A_1_C_1 2a5j_A_1_B_1 2a78_A_1_C_1 2a9k_A_1_C_1 2bov_A_1_D_1 2d7c_A_1_E_1 2d7c_B_1_H_1 2ew1_A_1_B_1 2f7s_A_1_C_1 2f7s_B_1_E_1 2f9l_A_1_B_1 2f9m_A_1_B_1 2fg5_A_1_B_1 2g77_B_1_C_1 2gil_A_1_E_1 2gil_B_1_G_1 2gil_C_1_I_1 2gil_D_1_K_1 2gzd_A_1_E_1 2gzd_B_1_G_1 2gzh_A_1_D_1 2gzh_A_2_D_2 2hv8_A_1_G_1 2hv8_A_2_G_2 2hv8_C_1_K_1 2hv8_E_1_P_1 2if0_A_1_C_1 2if0_B_1_E_1 2ocb_A_1_B_1 2rhd_A_1_B_1 2y8e_A_1_E_1 2y8e_B_1_I_1 2zet_A_1_E_1 2zet_C_1_J_1 3law_A_1_F_1 3law_B_1_H_1 3law_C_1_J_1 3law_D_1_L_1 3law_E_1_N_1 3mjh_A_1_F_1 3mjh_C_1_I_1 3nkv_A_1_D_1 3qbt_A_1_I_1 3qbt_B_1_K_1 3qbt_C_1_M_1 3qbt_D_1_O_1 3tkl_A_1_C_1 3tnf_A_1_C_1 4c4p_A_1_D_1 4d0g_A_1_D_1 4d0l_B_1_I_1 4d0l_D_1_L_1 4d0l_F_1_O_1 4d0m_B_1_MA_1 4d0m_D_1_PA_1 4d0m_DA_1_QB_1 4d0m_H_1_SA_1 4d0m_HA_1_TB_1 4d0m_J_1_VA_1 4d0m_N_1_YA_1 4d0m_P_1_BB_1 4d0m_R_1_EB_1 4d0m_T_1_HB_1 4d0m_X_1_KB_1 4d0m_Z_1_NB_1 4djt_A_1_D_1 4fmb_B_1_I_1 4fmb_B_2_I_2 4fmb_D_1_L_1 4fmb_D_2_L_2 4fmb_F_1_O_1 4fmb_F_2_O_2 4fmc_B_1_J_1 4fmc_D_1_M_1 4fmd_B_1_I_1 4fmd_D_1_M_1 4fmd_F_1_Q_1 4fme_B_1_I_1 4fme_E_1_N_1 4hlq_B_1_L_1 4hlq_D_1_P_1 4hlq_F_1_U_1 4hlq_H_1_X_1 4hlq_J_1_BA_1 4i1o_A_1_I_1 4i1o_C_1_M_1 4i1o_E_1_T_1 4i1o_G_1_W_1 4iru_B_1_S_1 4iru_D_1_HA_1 4iru_F_1_MA_1 4jvs_B_1_F_1 4kyi_B_1_P_1 4kyi_D_1_R_1 4kyi_F_1_V_1 4kyi_H_1_Y_1 4lhv_A_1_G_1 4lhv_B_1_I_1 4lhv_C_1_K_1 4lhv_D_1_M_1 4lhv_E_1_O_1 4lhw_A_1_F_1 4lhw_B_1_I_1 4lhw_C_1_K_1 4lhw_D_1_M_1 4lhw_E_1_O_1 4lwz_A_1_F_1 4lwz_C_1_H_1 4lx0_A_1_E_1 4lx0_C_1_I_1 4phf_A_1_C_1 4phg_A_1_B_1 4phh_A_1_F_1 4phh_B_1_I_1 4phh_C_1_L_1 4phh_D_1_N_1 4qxa_A_1_D_1 4uj3_A_1_Z_1 4uj3_D_1_BA_1 4uj3_G_1_DA_1 4uj3_J_1_FA_1 4uj3_M_1_HA_1 4uj3_P_1_KA_1 4uj3_S_1_MA_1 4uj3_V_1_OA_1 4uj4_A_1_N_1 4uj4_A_2_N_2 4uj4_D_1_P_1 4uj4_G_1_R_1 4uj4_J_1_T_1 4uj4_J_3_T_3 4uj5_A_1_F_1 4uj5_B_1_I_1 5c46_B_1_F_1 5c4g_A_1_C_1 5ez5_A_1_C_1 5ez5_B_1_E_1 5ez5_B_2_E_2 5jcz_A_1_G_1 5jcz_D_1_X_1 5jcz_F_1_EA_1 5lef_B_1_J_1 5szh_B_1_D_1 5szi_A_1_D_1 5szk_B_1_C_1 5xr4_A_1_E_1 5xr4_B_1_F_1 5xr6_A_1_D_1 5xr6_B_1_F_1 5xr7_A_1_D_1 5xr7_B_1_F_1 5z2m_B_1_E_1 6huf_A_1_Q_1 6huf_B_1_S_1 6huf_C_1_U_1 6huf_D_1_W_1 6huf_E_1_Y_1 6huf_F_1_AA_1 6huf_G_1_CA_1 6huf_H_1_EA_1 6huf_I_1_GA_1 6huf_J_1_IA_1 6huf_K_1_KA_1 6huf_L_1_MA_1 6huf_M_1_OA_1 6huf_N_1_QA_1 6huf_O_1_SA_1 6huf_P_1_UA_1 6iyb_A_1_E_1 6iyb_C_1_G_1 6l6o_A_1_E_1 6rir_A_1_F_1 6rir_B_1_I_1 6sku_B_1_D_1 6sq2_A_1_F_1 6sq2_B_1_H_1 6stf_A_1_G_1 6stf_D_1_M_1 6stf_E_1_O_1 6stg_A_1_D_1 6stg_B_1_F_1 6sur_D_1_S_1 6wcw_A_1_D_1 6whe_A_1_D_1 6whe_B_1_F_1 6y09_A_1_E_1 6y09_C_1_L_1 6yx5_A_1_C_1 6zay_A_1_J_1 6zay_C_1_V_1 6zsi_A_1_G_1 6zsi_B_1_J_1 6zsj_A_1_F_1 6zsj_B_1_H_1 7bl1_F_1_H_1 7bwt_B_1_K_1 7e1t_A_1_E_1 7e1t_B_1_G_1 7ezb_A_1_D_1 7ezb_B_1_F_1 7f6j_A_1_D_1 7f6j_B_1_F_1 7lwb_A_1_D_1 7lwb_A_2_D_2 7opp_A_1_D_1 7opp_B_1_F_1 7opq_A_1_E_1 7opq_B_1_N_1 7opr_A_1_D_1 7opr_B_1_N_1 [SR ] 1s8f_A_1_C_1 1s8f_A_2_C_2 [CO ] 1tu4_A_1_E_1 1tu4_A_2_E_2 1tu4_B_1_G_1 1tu4_B_2_G_2 1tu4_C_1_L_1 1tu4_C_2_L_2 1tu4_D_1_N_1 1tu4_D_2_N_2 [CA ] 2iez_A_1_E_1 2iez_B_1_G_1 2iez_C_1_I_1 2iez_D_1_K_1 4g01_B_1_C_1 6p0i_A_1_G_1 6p0j_A_1_C_1 6p0k_A_1_B_1 6p0l_A_1_B_1 6p0m_A_1_C_1 6p0n_A_1_B_1 6p0o_A_1_C_1 8fjh_A_1_D_1 8fji_A_1_D_1 precipitant [SO4 ] 3l0i_D_1_J_1 4lhx_A_1_G_1 4lhx_B_1_H_1 5ldd_C_1_G_1 5ldd_F_1_I_1 [AF3 ] 4fmc_B_1_H_1 4fmc_D_1_K_1 4jvs_B_1_E_1 [BEF ] 4hlq_B_1_N_1 4hlq_D_1_R_1 4i1o_E_1_V_1 [PEG ] 4i1o_C_1_Q_1 [EDO ] 4kyi_B_1_N_1 [IPA ] 5lef_B_1_M_1 [PO4 ] 6ixv_E_1_I_1 6ixv_F_1_J_1 6ixv_H_1_K_1 [GOL ] 7opq_A_1_I_1 7opq_B_1_P_1 7opr_A_1_H_1 7opr_B_1_O_1


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