Summary for the 157-th Site(K)
PID QueryLength FocusSite TITLE
2691701 207 157 K RecName: Full=Ras-related protein Rab-7a ; EC=3.6.5.2 ;
UniProt Information
AC/IDAC:P51149 ID:RAB7A_HUMAN
Feature Table for 157-th site VARIANT: /note="K -> N (in CMT2B; does not affect interaction with NTRK1; results in higher levels of NTRK1 and MAPK1/MAPK3 phosphorylation after NGF stimulation consistent with enhanced MAPK signaling; increases interaction with PRPH; dbSNP:rs121909081)" ECO:0000269|PubMed:21151572, ECO:0000269|PubMed:23179371" /id="VAR_037887"
BINDING: /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" ECO:0000269|PubMed:20028791"
TURN:
CHAIN: /note="Ras-related protein Rab-7a" /id="PRO_0000121121"
VARIANT for 157-th site K->N LP/P dbSNP:rs1219090 " Charcot-Marie-Tooth disease, axonal, 2B (CMT2B) " [MIM:600882]
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
K:65% L:12% A:5% R:5% T:5% M:2% S:2% Q:1% E:1% I:1% F:1% V:1%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
1vg8 T (Hbond turn) e (exposed) 41.0
3D Complex Information
Predicted Bind Molecules
hetero:34 homo:5 compound:335 metal:1 precipitant:5
Templates for 3D complexes
hetero [81454:PI4KB_HUMAN ] 4d0l_B_1_A_1 4d0l_D_1_C_1 4d0l_F_1_E_1 4d0m_B_1_A_1 4d0m_D_1_C_1 4d0m_H_1_G_1 4d0m_HA_1_GA_1 4d0m_J_1_I_1 4d0m_N_1_M_1 4d0m_P_1_O_1 4d0m_R_1_Q_1 4d0m_T_1_S_1 4d0m_X_1_W_1 4d0m_Z_1_Y_1 5c46_B_1_A_1 5c4g_A_1_B_1 5euq_A_1_B_1 [47935:RAB3I_HUMAN ] 4uj3_A_1_B_1 4uj3_D_1_E_1 4uj3_G_1_H_1 4uj3_J_1_K_1 4uj3_M_1_N_1 4uj3_P_1_Q_1 4uj3_S_1_T_1 4uj3_V_1_W_1 4uj4_A_1_B_1 4uj4_A_2_B_2 4uj4_D_1_E_1 4uj4_G_1_H_1 4uj4_J_1_K_1 4uj4_J_3_K_3 4uj5_A_1_C_1 [47968:RAB3I_HUMAN ] 4uj5_B_1_D_1 [99197:ANKX_LEGPH ] 6sku_B_1_A_1 homo [42780:RAB5A_HUMAN ] 1tu4_B_1_A_2 1tu4_B_2_A_1 1tu4_D_1_C_2 1tu4_D_2_C_1 [42080:RB11A_HUMAN ] 5ez5_A_1_B_1 compound [GNP ] 1ek0_A_1_D_1 1huq_A_1_C_1 1ky2_A_1_C_1 1n6h_A_1_C_1 1n6n_A_1_C_1 1n6o_A_1_C_1 1n6p_A_1_C_1 1n6r_A_1_C_1 1r2q_A_1_C_1 1tu3_A_1_L_1 1tu3_B_1_N_1 1tu3_C_1_P_1 1tu3_D_1_R_1 1tu3_E_1_T_1 1tu3_E_2_T_2 1u8y_A_1_E_1 1u8y_B_1_H_1 1uad_A_1_F_1 1uad_B_1_H_1 1vg8_A_1_F_1 1vg8_B_1_H_1 1vg8_C_1_J_1 1vg8_D_1_L_1 1x3s_A_1_C_1 1yvd_A_1_C_1 1yzk_A_1_C_1 1yzl_A_1_C_1 1z06_A_1_C_1 1z07_A_1_C_1 2ew1_A_1_C_1 2f9m_A_1_E_1 2fg5_A_1_C_1 2ocb_A_1_C_1 2y8e_A_1_D_1 2y8e_B_1_H_1 3law_A_1_G_1 3law_B_1_I_1 3law_C_1_K_1 3law_D_1_M_1 3law_E_1_O_1 3nkv_A_1_C_1 3qbt_A_1_J_1 3qbt_B_1_L_1 3qbt_C_1_N_1 3qbt_D_1_P_1 3tnf_A_1_D_1 4c4p_A_1_C_1 4kyi_B_1_M_1 4kyi_D_1_Q_1 4kyi_F_1_U_1 4kyi_H_1_X_1 4lhw_A_1_G_1 4lhw_B_1_J_1 4lhw_C_1_L_1 4lhw_D_1_N_1 4lhw_E_1_P_1 4uj3_A_1_Y_1 4uj3_D_1_AA_1 4uj3_G_1_CA_1 4uj3_J_1_EA_1 4uj3_M_1_GA_1 4uj3_P_1_JA_1 4uj3_S_1_LA_1 4uj3_V_1_NA_1 4uj4_A_1_M_1 4uj4_A_2_M_2 4uj4_D_1_O_1 4uj4_G_1_Q_1 4uj4_J_1_S_1 4uj4_J_3_S_3 4uj5_A_1_E_1 4uj5_B_1_H_1 5szh_B_1_C_1 5szi_A_1_C_1 5szk_B_1_D_1 5xr6_A_1_C_1 5xr6_B_1_E_1 6huf_A_1_R_1 6huf_B_1_T_1 6huf_C_1_V_1 6huf_D_1_X_1 6huf_E_1_Z_1 6huf_F_1_BA_1 6huf_G_1_DA_1 6huf_H_1_FA_1 6huf_I_1_HA_1 6huf_J_1_JA_1 6huf_K_1_LA_1 6huf_L_1_NA_1 6huf_M_1_PA_1 6huf_N_1_RA_1 6huf_O_1_TA_1 6stg_A_1_C_1 6stg_B_1_E_1 6yx5_A_1_D_1 6zsi_A_1_E_1 6zsi_B_1_H_1 6zsj_A_1_E_1 6zsj_B_1_G_1 7opp_A_1_C_1 7opp_B_1_E_1 7opq_A_1_D_1 7opq_B_1_M_1 7opr_A_1_C_1 7opr_B_1_M_1 [GDP ] 1ky3_A_1_C_1 1n6i_A_1_C_1 1n6k_A_1_C_1 1oiv_A_1_C_1 1oiv_B_1_F_1 1oix_A_1_B_1 1s8f_A_1_D_1 1s8f_A_2_D_2 1s8f_B_1_K_1 1s8f_B_2_K_2 1tu4_A_1_F_1 1tu4_A_2_F_2 1tu4_B_1_K_1 1tu4_B_2_K_2 1tu4_C_1_M_1 1tu4_C_2_M_2 1tu4_D_1_T_1 1tu4_D_2_T_2 1u90_A_1_D_1 1u90_B_1_F_1 1vg0_B_1_F_1 1vg1_A_1_C_1 1vg9_B_1_K_1 1vg9_D_1_O_1 1vg9_F_1_S_1 1vg9_H_1_W_1 1wms_A_1_C_1 1wms_B_1_D_1 1z0a_A_1_F_1 1z0a_B_1_H_1 1z0a_C_1_J_1 1z0a_D_1_L_1 1z0d_A_1_E_1 1z0d_B_1_G_1 1z0f_A_1_C_1 2a5j_A_1_C_1 2a78_A_1_D_1 2a9k_A_1_D_1 2bov_A_1_C_1 2efc_B_1_E_1 2efc_D_1_F_1 2efh_B_1_E_1 2efh_D_1_F_1 2f7s_A_1_D_1 2f7s_B_1_F_1 2f9l_A_1_C_1 2g77_B_1_D_1 2hei_A_1_C_1 2hei_B_1_E_1 2iey_B_1_D_1 2iey_B_2_D_2 2iez_A_1_F_1 2iez_B_1_H_1 2iez_C_1_J_1 2iez_D_1_L_1 2if0_A_1_D_1 2if0_B_1_F_1 2rhd_A_1_E_1 3sfv_A_1_C_1 4djt_A_1_C_1 4fmb_B_1_H_1 4fmb_B_2_H_2 4fmb_D_1_K_1 4fmb_D_2_K_2 4fmb_F_1_N_1 4fmb_F_2_N_2 4fmc_B_1_I_1 4fmc_D_1_L_1 4fmd_B_1_H_1 4fmd_D_1_L_1 4fmd_F_1_P_1 4fme_B_1_H_1 4fme_E_1_M_1 4g01_B_1_D_1 4hlq_B_1_M_1 4hlq_D_1_Q_1 4hlq_F_1_V_1 4hlq_H_1_Y_1 4hlq_J_1_CA_1 4i1o_A_1_J_1 4i1o_C_1_N_1 4i1o_E_1_U_1 4i1o_G_1_X_1 4iru_B_1_T_1 4iru_D_1_IA_1 4iru_F_1_NA_1 4jvs_B_1_D_1 4lhv_A_1_F_1 4lhv_B_1_H_1 4lhv_C_1_J_1 4lhv_D_1_L_1 4lhv_E_1_N_1 4lhy_A_1_G_1 4lhy_B_1_H_1 4li0_A_1_G_1 4li0_B_1_H_1 4lwz_A_1_E_1 4lwz_C_1_G_1 4lx0_A_1_G_1 4lx0_C_1_K_1 4ojk_A_1_E_1 4ojk_B_1_F_1 4ojk_B_2_F_2 5c4g_A_1_D_1 5euq_A_1_C_1 5fbq_B_1_D_1 5jcz_A_1_H_1 5jcz_D_1_Y_1 5jcz_F_1_FA_1 5o74_F_1_O_1 5o74_J_1_Q_1 5o74_L_1_R_1 5xr4_A_1_D_1 5xr4_B_1_H_1 6iy1_A_1_G_1 6iy1_B_1_H_1 6iy1_C_1_I_1 6iy1_D_1_J_1 6iy1_E_1_K_1 6iy1_F_1_L_1 6l6o_A_1_B_1 6o62_A_1_B_1 6o62_A_2_B_2 6p0i_A_1_B_1 6p0j_A_1_B_1 6p0k_A_1_E_1 6p0l_A_1_D_1 6p0m_A_1_E_1 6p0n_A_1_F_1 6p0o_A_1_B_1 6sku_B_1_C_1 6stf_A_1_F_1 6stf_D_1_L_1 6stf_E_1_N_1 6zay_A_1_K_1 6zay_C_1_W_1 7bwt_B_1_J_1 7ezb_A_1_C_1 7ezb_B_1_E_1 8fjh_A_1_B_1 8fji_A_1_B_1 [GTP ] 1n6l_A_1_C_1 1t91_A_1_F_1 1t91_B_1_H_1 1t91_C_1_J_1 1t91_D_1_L_1 1yhn_A_1_D_1 1yhn_A_2_D_2 1z0j_A_1_D_1 2d7c_A_1_F_1 2d7c_B_1_I_1 2gil_A_1_F_1 2gil_B_1_H_1 2gil_C_1_J_1 2gil_D_1_L_1 2gzd_A_1_F_1 2gzd_B_1_H_1 2gzh_A_1_F_1 2gzh_A_2_F_2 2hv8_A_1_I_1 2hv8_A_2_I_2 2hv8_C_1_N_1 2hv8_E_1_S_1 2zet_A_1_F_1 2zet_C_1_K_1 3mjh_A_1_E_1 3mjh_C_1_H_1 3tkl_A_1_D_1 4d0g_A_1_C_1 4lhz_A_1_G_1 4lhz_B_1_H_1 4qxa_A_1_C_1 5ez5_A_1_D_1 5ez5_B_1_F_1 5ez5_B_2_F_2 5lef_B_1_I_1 5xr7_A_1_C_1 5xr7_B_1_E_1 5z2m_B_1_F_1 5z2m_C_1_G_1 6iyb_A_1_F_1 6iyb_C_1_H_1 6rir_A_1_E_1 6rir_B_1_H_1 6sq2_A_1_E_1 6sq2_B_1_G_1 6sur_D_1_T_1 6wcw_A_1_C_1 6whe_A_1_C_1 6whe_B_1_E_1 6y09_A_1_F_1 6y09_C_1_M_1 7bl1_F_1_G_1 7e1t_A_1_F_1 7e1t_B_1_H_1 7f6j_A_1_E_1 7f6j_B_1_G_1 7lwb_A_1_C_1 7lwb_A_2_C_2 [GSP ] 1oiw_A_1_B_1 4d0l_B_1_H_1 4d0l_D_1_K_1 4d0l_F_1_N_1 4d0m_B_1_LA_1 4d0m_D_1_OA_1 4d0m_DA_1_PB_1 4d0m_H_1_RA_1 4d0m_HA_1_SB_1 4d0m_J_1_UA_1 4d0m_N_1_XA_1 4d0m_P_1_AB_1 4d0m_R_1_DB_1 4d0m_T_1_GB_1 4d0m_X_1_JB_1 4d0m_Z_1_MB_1 5c46_B_1_E_1 5fbl_B_1_D_1 5fbr_B_1_D_1 5fbv_B_1_D_1 5fbw_B_1_D_1 7ezd_B_1_D_1 7eze_B_1_E_1 [GNH ] 2efe_B_1_E_1 2efe_D_1_F_1 [2UH ] 4phf_A_1_B_1 [2UJ ] 4phg_A_1_C_1 [2UK ] 4phh_A_1_E_1 4phh_B_1_H_1 4phh_C_1_K_1 4phh_D_1_M_1 metal [K ] 4iru_B_1_Y_1 precipitant [PEG ] 4i1o_A_1_L_1 4i1o_G_1_Z_1 6y09_C_1_P_1 [ACT ] 4iru_D_1_LA_1 [EDO ] 6zay_C_1_P_1


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