Summary for the 162-nd Site(V)
PID QueryLength FocusSite TITLE
2691701 207 162 V RecName: Full=Ras-related protein Rab-7a ; EC=3.6.5.2 ;
UniProt Information
AC/IDAC:P51149 ID:RAB7A_HUMAN
Feature Table for 162-th site VARIANT: /note="V -> M (in CMT2B; increases GTP hydrolysis; decreases affinity for GTP and GDP; does not affect interaction with NTRK1; results in higher levels of NTRK1 and MAPK1/MAPK3 phosphorylation after NGF stimulation consistent with enhanced MAPK signaling; increases interaction with PRPH; dbSNP:rs121909079)" ECO:0000269|PubMed:20028791, ECO:0000269|PubMed:21151572, ECO:0000269|PubMed:23179371" /id="VAR_018723"
CHAIN: /note="Ras-related protein Rab-7a" /id="PRO_0000121121"
VARIANT for 162-th site V->M LP/P dbSNP:rs1219090 " Charcot-Marie-Tooth disease, axonal, 2B (CMT2B) " [MIM:600882]
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
V:60% I:20% L:9% F:3% T:2% A:1% E:1% K:1% M:1% Y:1%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
1vg8 H (alpha-helix) b (buried) 2.0
3D Complex Information
Predicted Bind Molecules
hetero:111 homo:1 metal:4 precipitant:6
Templates for 3D complexes
hetero [49223:RANG_HUMAN ] 1k5d_J_1_K_1 [99777:TNPO1_HUMAN ] 1qbk_B_1_A_1 1qbk_B_2_A_2 [34724:RBP2_HUMAN ] 1rrp_A_1_B_1 1rrp_A_2_B_2 5cll_A_1_B_1 5cll_C_1_D_1 5clq_A_1_B_1 5clq_C_1_D_1 7mnw_A_1_B_1 7mnw_C_1_D_1 7mnw_E_1_F_1 7mnw_G_1_H_1 [99888:IMB1_YEAST ] 2bku_A_1_B_1 2bku_C_1_D_1 3ea5_A_1_B_1 3ea5_C_1_D_1 [35851:YRB1_YEAST ] 3m1i_A_1_B_1 4gmx_A_1_B_1 4gpt_A_1_B_1 4hat_A_1_B_1 4hau_A_1_B_1 4hav_A_1_B_1 4haw_A_1_B_1 4hax_B_1_C_1 4hay_A_1_B_1 4haz_A_1_B_1 4hb0_A_1_B_1 4hb2_A_1_B_1 4hb3_A_1_B_1 4hb4_A_1_B_1 4wvf_A_1_B_1 5dh9_A_1_B_1 5dha_A_1_B_1 5dhf_A_1_B_1 5di9_A_1_B_1 5dif_A_1_B_1 5jlj_A_1_B_1 5uwh_A_1_B_1 5uwi_A_1_B_1 5uwj_A_1_B_1 5uwo_A_1_B_1 5uwp_A_1_B_1 5uwq_A_1_B_1 5uwr_A_1_B_1 5uws_A_1_B_1 5uwt_A_1_B_1 5uwu_A_1_B_1 5uww_A_1_B_1 5yro_A_1_B_1 5yst_A_1_B_1 5ysu_A_1_B_1 5ytb_A_1_B_1 5zpu_A_1_B_1 6a38_A_1_B_1 6a3a_A_1_B_1 6a3b_A_1_B_1 6a3c_A_1_B_1 6a3e_A_1_B_1 6cit_A_1_B_1 6kft_A_1_B_1 6lq9_A_1_B_1 6m60_A_1_B_1 6m6x_A_1_B_1 6x2m_A_1_B_1 6x2o_A_1_B_1 6x2p_A_1_B_1 6x2r_A_1_B_1 6x2s_A_1_B_1 6x2u_A_1_B_1 6x2v_A_1_B_1 6x2w_A_1_B_1 6x2x_A_1_B_1 6x2y_A_1_B_1 6xjp_A_1_B_1 6xjr_A_1_B_1 6xjs_A_1_B_1 6xjt_A_1_B_1 6xju_A_1_B_1 7cnd_A_1_B_1 7dbg_A_1_B_1 7l5e_A_1_B_1 7ypz_A_1_B_1 8hq3_A_1_B_1 8hq4_A_1_B_1 8hq5_A_1_B_1 8hq6_A_1_B_1 8huf_A_1_B_1 8hug_A_1_B_1 8itv_A_1_B_1 [59740:YRB2_YEAST ] 3wyf_A_1_B_1 [33699:RBP2_HUMAN ] 7mnx_A_1_B_1 7mnx_C_1_D_1 7mnx_E_1_F_1 7mnx_G_1_H_1 7mnx_I_1_J_1 7mnx_K_1_L_1 [36345:RBP2_HUMAN ] 7mny_A_1_B_1 7mny_C_1_D_1 7mny_E_1_F_1 7mny_G_1_H_1 7mny_I_1_J_1 7mny_K_1_L_1 [36003:RBP2_HUMAN ] 7mnz_A_1_B_1 7mnz_C_1_D_1 7mnz_E_1_F_1 7mnz_G_1_H_1 7mnz_I_1_J_1 7mnz_K_1_L_1 [31994:NUP50_HUMAN ] 7mo0_A_1_B_1 7mo0_C_1_D_1 homo [42271:RASK_HUMAN ] 8stn_A_1_B_1 metal [UNX ] 2ocb_A_1_G_1 [CL ] 4phh_B_1_J_1 4phh_D_1_O_1 6xi7_A_1_I_1 precipitant [NO3 ] 4phf_A_1_D_1 [SO4 ] 5lef_B_1_L_1 6yx5_A_1_G_1 [EDO ] 6mbq_A_1_C_1 [PCW ] 6pts_C_1_KB_1 [GOL ] 7bwt_B_1_L_1


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