Summary for the 161-st Site(N)
PID QueryLength FocusSite TITLE
2691701 207 161 N RecName: Full=Ras-related protein Rab-7a ; EC=3.6.5.2 ;
UniProt Information
AC/IDAC:P51149 ID:RAB7A_HUMAN
Feature Table for 161-th site VARIANT: /note="N -> T (in CMT2B; does not affect interaction with NTRK1; results in higher levels of NTRK1 and MAPK1/MAPK3 phosphorylation after NGF stimulation consistent with enhanced MAPK signaling; increases interaction with PRPH; dbSNP:rs121909080)" ECO:0000269|PubMed:21151572, ECO:0000269|PubMed:23179371" /id="VAR_037888"
CHAIN: /note="Ras-related protein Rab-7a" /id="PRO_0000121121"
VARIANT for 161-th site N->T LP/P dbSNP:rs1219090 " Charcot-Marie-Tooth disease, axonal, 2B (CMT2B) " [MIM:600882]
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
N:66% G:18% S:4% R:2% H:2% T:2% D:1% C:1% Q:1% E:1% L:1% K:1%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
1vg8 S (bend) e (exposed) 35.8
3D Complex Information
Predicted Bind Molecules
hetero:57 homo:9 compound:2 metal:7 precipitant:14
Templates for 3D complexes
hetero [86619:IMB1_HUMAN ] 1ibr_C_1_D_1 [99777:TNPO1_HUMAN ] 1qbk_B_1_A_1 1qbk_B_2_A_2 [99888:IMB1_YEAST ] 2bku_A_1_B_1 2bku_C_1_D_1 3ea5_A_1_B_1 3ea5_C_1_D_1 [100844:XPOT_SCHPO ] 3icq_B_1_A_1 3icq_E_1_D_1 [100949:XPO1_YEAST ] 3m1i_A_1_C_1 3wyf_D_1_F_1 4gmx_A_1_C_1 4gpt_A_1_C_1 4hat_A_1_C_1 4hau_A_1_C_1 4hav_A_1_C_1 4haw_A_1_C_1 4hax_B_1_A_1 4hay_A_1_C_1 4haz_A_1_C_1 4hb0_A_1_C_1 4hb3_A_1_C_1 4hb4_A_1_C_1 4wvf_A_1_C_1 5jlj_A_1_C_1 5yst_A_1_C_1 5ysu_A_1_C_1 5zpu_A_1_C_1 6lq9_A_1_C_1 6xjp_A_1_C_1 6xjr_A_1_C_1 6xjs_A_1_C_1 6xjt_A_1_C_1 6xju_A_1_C_1 [100478:TNPO3_HUMAN ] 4c0q_C_1_A_1 [34724:RBP2_HUMAN ] 5cll_A_1_B_1 5cll_C_1_D_1 [24064 ] 5e95_B_1_A_1 [99197:ANKX_LEGPH ] 6sku_B_1_A_1 [102208:TR120_YEAST ] 7e8t_A_1_C_1 7ea3_L_1_J_1 7ea3_X_1_V_1 [33699:RBP2_HUMAN ] 7mnx_A_1_B_1 7mnx_E_1_F_1 7mnx_G_1_H_1 7mnx_K_1_L_1 [36345:RBP2_HUMAN ] 7mny_A_1_B_1 7mny_C_1_D_1 7mny_E_1_F_1 7mny_G_1_H_1 7mny_I_1_J_1 7mny_K_1_L_1 [36003:RBP2_HUMAN ] 7mnz_K_1_L_1 [102211:TR120_YEAST ] 7u05_K_1_N_1 7u05_X_1_Z_1 7u06_J_1_W_1 [100952:IMB5_YEAST ] 8f1e_D_1_A_1 homo [43129:SEC4_YEAST ] 1g16_D_1_C_1 [47469:RAB43_HUMAN ] 2il1_A_1_A_2 2il1_A_2_A_1 [42271:RASK_HUMAN ] 4lrw_B_1_A_1 6w4f_C_1_D_1 6w4f_D_1_C_1 7acf_B_1_A_1 [42493:RAP1B_HUMAN ] 7c7i_A_1_B_1 7c7i_B_1_A_1 compound [17F ] 6pts_C_1_EC_1 [GLC ] 6yx5_A_1_E_1 metal [UNX ] 2il1_A_1_E_1 2il1_A_2_E_2 2ocb_A_1_G_1 2p5s_A_1_D_1 [CL ] 4phh_B_1_J_1 4phh_D_1_O_1 6xi7_A_1_I_1 precipitant [TRS ] 2bme_A_1_F_1 2bme_C_1_M_1 2bme_D_1_P_1 [PCW ] 2msc_C_1_S_1 6pts_C_1_KB_1 [SO4 ] 2y8e_B_1_G_1 5lef_B_1_L_1 6yx5_A_1_G_1 [NO3 ] 4phf_A_1_D_1 [ACT ] 5jcz_A_1_M_1 [PEG ] 5oct_A_1_I_1 8cnn_A_1_D_1 [GOL ] 6ark_A_1_F_1 6ntc_A_1_D_1


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