Summary for the 22-nd Site(T)
PID QueryLength FocusSite TITLE
2691701 207 22 T RecName: Full=Ras-related protein Rab-7a ; EC=3.6.5.2 ;
UniProt Information
AC/IDAC:P51149 ID:RAB7A_HUMAN
Feature Table for 22-th site MUTAGEN: /note="T->N: Abolishes localization on late endosomes, lysosomes and phagosomes and reduces phagosomal fusions. Abolishes association of RILP with the phagosomes. No loss of interaction with CLN5. No loss of interaction with PRPH. Reduced interaction with VPS13A. Inhibits SARS-CoV-2 infection." ECO:0000269|PubMed:22431521, ECO:0000269|PubMed:23179371, ECO:0000269|PubMed:30709847, ECO:0000269|PubMed:34159616"
BINDING: /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" ECO:0000269|PubMed:20028791"
HELIX:
CHAIN: /note="Ras-related protein Rab-7a" /id="PRO_0000121121"
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
T:53% S:44% G:1% L:1% K:1%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
1vg8 H (alpha-helix) e (exposed) 26.6
3D Complex Information
Predicted Bind Molecules
compound:28 metal:27
Templates for 3D complexes
compound [GTP ] 1t91_A_1_F_1 1t91_B_1_H_1 1t91_C_1_J_1 1t91_D_1_L_1 1yhn_A_1_D_1 1yhn_A_2_D_2 5z2m_B_1_F_1 5z2m_C_1_G_1 6iyb_A_1_F_1 6iyb_C_1_H_1 6wcw_A_1_C_1 7f6j_A_1_E_1 7f6j_B_1_G_1 [GDP ] 1vg0_B_1_F_1 1vg1_A_1_C_1 1vg9_B_1_K_1 1vg9_D_1_O_1 1vg9_F_1_S_1 1vg9_H_1_W_1 [GNP ] 1vg8_A_1_F_1 1vg8_B_1_H_1 1vg8_C_1_J_1 1vg8_D_1_L_1 3law_A_1_G_1 3law_B_1_I_1 3law_C_1_K_1 3law_D_1_M_1 3law_E_1_O_1 metal [MG ] 1t91_A_1_E_1 1t91_B_1_G_1 1t91_C_1_I_1 1t91_D_1_K_1 1vg0_B_1_E_1 1vg1_A_1_B_1 1vg8_A_1_E_1 1vg8_B_1_G_1 1vg8_C_1_I_1 1vg8_D_1_K_1 1vg9_B_1_I_1 1vg9_D_1_M_1 1vg9_F_1_Q_1 1vg9_H_1_U_1 1yhn_A_1_C_1 1yhn_A_2_C_2 3law_A_1_F_1 3law_B_1_H_1 3law_C_1_J_1 3law_D_1_L_1 3law_E_1_N_1 5z2m_B_1_E_1 6iyb_A_1_E_1 6iyb_C_1_G_1 6wcw_A_1_D_1 7f6j_A_1_D_1 7f6j_B_1_F_1


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