Summary for the 162-nd Site(V) |
PID | QueryLength | FocusSite | TITLE |
2691701 | 207 | 162 V | RecName: Full=Ras-related protein Rab-7a ; EC=3.6.5.2 ; |
AC/ID | AC:P51149 ID:RAB7A_HUMAN |
Feature Table for 162-th site |
VARIANT: /note="V -> M (in CMT2B; increases GTP hydrolysis; decreases affinity for GTP and GDP; does not affect interaction with NTRK1; results in higher levels of NTRK1 and MAPK1/MAPK3 phosphorylation after NGF stimulation consistent with enhanced MAPK signaling; increases interaction with PRPH; dbSNP:rs121909079)" ECO:0000269|PubMed:20028791, ECO:0000269|PubMed:21151572, ECO:0000269|PubMed:23179371" /id="VAR_018723" CHAIN: /note="Ras-related protein Rab-7a" /id="PRO_0000121121" |
VARIANT for 162-th site |
V->M LP/P dbSNP:rs1219090 " Charcot-Marie-Tooth disease, axonal, 2B (CMT2B) " [MIM:600882] |
Percentages of Amino Acids in Homologous Proteins [show alignment] |
V:60% I:20% L:9% F:3% T:2% A:1% E:1% K:1% M:1% Y:1% |
Template For Monomer | predicted SecStr | predicted ExpBur | Predicted Relative Acc(%) |
1vg8 | H (alpha-helix) | b (buried) | 2.0 |
Predicted Bind Molecules |
metal:3 precipitant:1 |
Templates for 3D complexes |
metal [UNX ] 2ocb_A_1_G_1 [CL ] 4phh_B_1_J_1 4phh_D_1_O_1 precipitant [NO3 ] 4phf_A_1_D_1 |
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