Summary for the 129-th Site(L) |
PID | QueryLength | FocusSite | TITLE |
2691701 | 207 | 129 L | RecName: Full=Ras-related protein Rab-7a ; EC=3.6.5.2 ; |
AC/ID | AC:P51149 ID:RAB7A_HUMAN |
Feature Table for 129-th site |
VARIANT: /note="L -> F (in CMT2B; increases GTP hydrolysis; decreases affinity for GTP and GDP; does not affect interaction with NTRK1; results in higher levels of NTRK1 and MAPK1/MAPK3 phosphorylation after NGF stimulation consistent with enhanced MAPK signaling; increases interaction with PRPH; dbSNP:rs121909078)" ECO:0000269|PubMed:20028791, ECO:0000269|PubMed:21151572, ECO:0000269|PubMed:23179371" /id="VAR_018722" STRAND: CHAIN: /note="Ras-related protein Rab-7a" /id="PRO_0000121121" |
VARIANT for 129-th site |
L->F LP/P dbSNP:rs1219090 " Charcot-Marie-Tooth disease, axonal, 2B (CMT2B) " [MIM:600882] |
Percentages of Amino Acids in Homologous Proteins [show alignment] |
L:65% M:7% I:6% V:5% K:4% A:3% R:2% D:1% C:1% Q:1% E:1% H:1% F:1% P:1% S:1% T:1% |
Template For Monomer | predicted SecStr | predicted ExpBur | Predicted Relative Acc(%) |
1vg8 | S (bend) | e (exposed) | 44.4 |
Predicted Bind Molecules |
compound:39 |
Templates for 3D complexes |
compound [GDP ] 1s8f_A_1_D_1 1s8f_A_2_D_2 1s8f_B_1_K_1 1s8f_B_2_K_2 1vg0_B_1_F_1 1vg1_A_1_C_1 1vg9_B_1_K_1 1vg9_D_1_O_1 1vg9_F_1_S_1 1vg9_H_1_W_1 1wms_A_1_C_1 1wms_B_1_D_1 [GTP ] 1t91_A_1_F_1 1t91_B_1_H_1 1t91_C_1_J_1 1t91_D_1_L_1 1yhn_A_1_D_1 1yhn_A_2_D_2 4qxa_A_1_C_1 5z2m_B_1_F_1 5z2m_C_1_G_1 6iyb_A_1_F_1 6iyb_C_1_H_1 6wcw_A_1_C_1 7e1t_A_1_F_1 7e1t_B_1_H_1 7f6j_A_1_E_1 7f6j_B_1_G_1 [GNP ] 1vg8_A_1_F_1 1vg8_B_1_H_1 1vg8_C_1_J_1 1vg8_D_1_L_1 1yzl_A_1_C_1 2ocb_A_1_C_1 3law_A_1_G_1 3law_B_1_I_1 3law_C_1_K_1 3law_D_1_M_1 3law_E_1_O_1 |
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