Summary for the 157-th Site(K) |
PID | QueryLength | FocusSite | TITLE |
2691701 | 207 | 157 K | RecName: Full=Ras-related protein Rab-7a ; EC=3.6.5.2 ; |
AC/ID | AC:P51149 ID:RAB7A_HUMAN |
Feature Table for 157-th site |
VARIANT: /note="K -> N (in CMT2B; does not affect interaction with NTRK1; results in higher levels of NTRK1 and MAPK1/MAPK3 phosphorylation after NGF stimulation consistent with enhanced MAPK signaling; increases interaction with PRPH; dbSNP:rs121909081)" ECO:0000269|PubMed:21151572, ECO:0000269|PubMed:23179371" /id="VAR_037887" BINDING: /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" ECO:0000269|PubMed:20028791" TURN: CHAIN: /note="Ras-related protein Rab-7a" /id="PRO_0000121121" |
VARIANT for 157-th site |
K->N LP/P dbSNP:rs1219090 " Charcot-Marie-Tooth disease, axonal, 2B (CMT2B) " [MIM:600882] |
Percentages of Amino Acids in Homologous Proteins [show alignment] |
K:65% L:12% A:5% R:5% T:5% M:2% S:2% Q:1% E:1% I:1% F:1% V:1% |
Template For Monomer | predicted SecStr | predicted ExpBur | Predicted Relative Acc(%) |
1vg8 | T (Hbond turn) | e (exposed) | 41.0 |
Predicted Bind Molecules |
compound:10 |
Templates for 3D complexes |
compound [GDP ] 1vg0_B_1_F_1 1vg1_A_1_C_1 1vg9_B_1_K_1 1vg9_D_1_O_1 1vg9_F_1_S_1 1vg9_H_1_W_1 [GNP ] 1vg8_A_1_F_1 1vg8_B_1_H_1 1vg8_C_1_J_1 1vg8_D_1_L_1 |
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