Summary for the 572-nd Site(G)
PID QueryLength FocusSite TITLE
2684896 1041 572 G RecName: Full=Toll-like receptor 8 ;AltName: CD_antigen=CD288;Flags: Precursor;
UniProt Information
AC/IDAC:Q9NR97 ID:TLR8_HUMAN
Feature Table for 572-th site VARIANT: /note="G -> D (in IMD98; gain-of-function variant resulting in increased NF-kappa-B activation measured in a reporter assay; dbSNP:rs1385657144)" /id="VAR_087090"
VARIANT: /note="G -> V (in IMD98; increased NF-kappa-B activation measured in a reporter assay; results in increased TLR8 protein degradation)" /id="VAR_087091"
TURN:
REPEAT: /note="LRR 16"
TOPO_DOM: /note="Extracellular"
CHAIN: /note="Toll-like receptor 8" /id="PRO_0000034735"
VARIANT for 572-th site G->D LP/P dbSNP:rs1385657 " Immunodeficiency 98 with autoinflammation, X-linked (IMD98) " [MIM:301078]
G->V LP/P " Immunodeficiency 98 with autoinflammation, X-linked (IMD98) " [MIM:301078]
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
G:31% A:10% E:8% S:8% K:6% R:5% N:4% P:4% C:3% Q:3% T:3% V:3% D:2% H:2% I:2% L:2% F:2% M:1% Y:1%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
4qbz T (Hbond turn) e (exposed) 91.7
3D Complex Information
Predicted Bind Molecules
homo:66 compound:42
Templates for 3D complexes
homo [99150:TLR8_HUMAN ] 3w3j_A_1_B_1 3w3j_B_1_A_1 3w3k_A_1_B_1 3w3k_B_1_A_1 3w3l_A_1_D_1 3w3l_B_1_C_1 3w3l_C_1_B_1 3w3l_D_1_A_1 3w3m_A_1_A_2 3w3m_A_2_A_1 3w3n_A_1_B_1 3w3n_B_1_A_1 4qbz_A_1_B_1 4qbz_B_1_A_1 4qc0_A_1_B_1 4qc0_B_1_A_1 4r07_A_1_B_1 4r07_B_1_A_1 4r07_C_1_D_1 4r07_D_1_C_1 4r08_A_1_B_1 4r08_B_1_A_1 4r08_C_1_D_1 4r08_D_1_C_1 4r09_A_1_B_1 4r09_B_1_A_1 4r09_C_1_D_1 4r09_D_1_C_1 4r0a_A_1_A_2 4r0a_A_2_A_1 4r6a_A_1_B_1 4r6a_B_1_A_1 5awa_A_1_A_2 5awa_A_2_A_1 5awb_A_1_A_2 5awb_A_2_A_1 5awc_A_1_B_1 5awc_B_1_A_1 5awc_C_1_D_1 5awc_D_1_C_1 5awd_A_1_A_2 5awd_A_2_A_1 5az5_A_1_B_1 5az5_B_1_A_1 5az5_C_1_D_1 5az5_D_1_C_1 5wyx_A_1_B_1 5wyz_A_1_B_1 5wyz_B_1_A_1 5z14_A_1_B_1 5z14_B_1_A_1 5z15_A_1_B_1 5z15_B_1_A_1 6kya_A_1_B_1 6kya_B_1_A_1 6v9u_A_1_B_1 6v9u_B_1_A_1 6wml_A_1_B_1 6wml_B_1_A_1 6wml_C_1_D_1 6zjz_A_1_B_1 6zjz_B_1_A_1 7crf_A_1_B_1 7crf_B_1_A_1 7r53_B_1_A_1 [99299:TLR8_HUMAN ] 6wml_D_1_C_1 compound [C09 ] 3w3j_A_1_M_1 3w3j_B_1_V_1 [L07 ] 3w3k_A_1_I_1 3w3k_B_1_M_1 [RX8 ] 3w3l_A_1_KA_1 3w3l_B_1_AA_1 3w3l_C_1_EA_1 3w3l_D_1_JA_1 3w3m_A_1_E_2 3w3m_A_2_E_1 3w3n_A_1_O_1 3w3n_B_1_Q_1 [D80 ] 4qbz_A_1_O_1 4qbz_B_1_P_1 [XG1 ] 4qc0_A_1_J_1 4qc0_B_1_K_1 [URI ] 4r07_D_1_EA_1 4r08_D_1_FA_1 [UPT ] 4r09_A_1_V_1 4r09_B_1_R_1 4r09_C_1_CA_1 4r09_D_1_Y_1 [HB2 ] 4r6a_A_1_M_1 4r6a_B_1_N_1 [M8D ] 5awa_A_1_E_2 5awa_A_2_E_1 [M0A ] 5awb_A_1_E_2 5awb_A_2_E_1 [M4D ] 5awc_A_1_T_1 5awc_B_1_U_1 5awc_C_1_Z_1 5awc_D_1_AA_1 [IDQ ] 5awd_A_1_E_2 5awd_A_2_E_1 [MBL ] 5az5_A_1_U_1 5az5_B_1_Q_1 5az5_C_1_EA_1 5az5_D_1_Z_1 [U57 ] 6wml_A_1_X_1 6wml_B_1_GA_1 6wml_C_1_NA_1 6wml_D_1_TA_1


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