Summary for the 574-th Site(T)
PID QueryLength FocusSite TITLE
2684896 1041 574 T RecName: Full=Toll-like receptor 8 ;AltName: CD_antigen=CD288;Flags: Precursor;
UniProt Information
AC/IDAC:Q9NR97 ID:TLR8_HUMAN
Feature Table for 574-th site MUTAGEN: /note="T->A: Abolishes responses to both ssRNA and chemical ligands."
MUTAGEN: /note="T->A: Strongly decreases activation of NF-kappa-B."
REPEAT: /note="LRR 16"
TOPO_DOM: /note="Extracellular"
CHAIN: /note="Toll-like receptor 8" /id="PRO_0000034735"
Evolutionary Information
Percentages of Amino Acids in Homologous Proteins [show alignment] 
T:16% L:11% P:11% I:9% V:6% C:5% E:5% K:5% F:5% S:5% A:4% G:4% R:3% D:3% N:2% Q:2% M:2% Y:2% H:1%
3D Structure Information
Template For Monomer predicted SecStr predicted ExpBur Predicted Relative Acc(%)
4qbz (coil) e (exposed) 38.3
3D Complex Information
Predicted Bind Molecules
homo:106 compound:100 precipitant:2
Templates for 3D complexes
homo [99150:TLR8_HUMAN ] 3w3j_A_1_B_1 3w3j_B_1_A_1 3w3k_A_1_B_1 3w3k_B_1_A_1 3w3l_A_1_D_1 3w3l_B_1_C_1 3w3l_C_1_B_1 3w3l_D_1_A_1 3w3m_A_1_A_2 3w3m_A_2_A_1 3w3n_A_1_B_1 3w3n_B_1_A_1 4qbz_A_1_B_1 4qbz_B_1_A_1 4qc0_A_1_B_1 4qc0_B_1_A_1 4r07_A_1_B_1 4r07_B_1_A_1 4r07_C_1_D_1 4r07_D_1_C_1 4r08_A_1_B_1 4r08_B_1_A_1 4r08_C_1_D_1 4r08_D_1_C_1 4r09_B_1_A_1 4r09_C_1_D_1 4r09_D_1_C_1 4r0a_A_1_A_2 4r0a_A_2_A_1 4r6a_A_1_B_1 4r6a_B_1_A_1 5awa_A_1_A_2 5awa_A_2_A_1 5awb_A_1_A_2 5awb_A_2_A_1 5awc_A_1_B_1 5awc_B_1_A_1 5awc_C_1_D_1 5awc_D_1_C_1 5awd_A_1_A_2 5awd_A_2_A_1 5az5_A_1_B_1 5az5_B_1_A_1 5az5_C_1_D_1 5az5_D_1_C_1 5wyx_A_1_B_1 5wyx_B_1_A_1 5wyz_A_1_B_1 5wyz_B_1_A_1 5z14_A_1_B_1 5z14_B_1_A_1 5z15_A_1_B_1 5z15_B_1_A_1 6kya_A_1_B_1 6wml_A_1_B_1 6wml_B_1_A_1 6wml_C_1_D_1 [99352:B3Y653_MACMU ] 5gmf_A_1_C_1 5gmf_B_1_D_1 5gmf_C_1_A_1 5gmf_D_1_B_1 5gmg_A_1_B_1 5gmg_B_1_A_1 5gmh_A_1_B_1 5gmh_B_1_A_1 5zsa_A_1_B_1 5zsa_B_1_A_1 5zsb_A_1_B_1 5zsb_B_1_A_1 5zsc_A_1_B_1 5zsc_B_1_A_1 5zsd_A_1_B_1 5zsd_B_1_A_1 5zse_A_1_B_1 5zse_B_1_A_1 5zsf_A_1_B_1 5zsf_B_1_A_1 5zsg_A_1_B_1 5zsg_B_1_A_1 5zsh_A_1_B_1 5zsh_B_1_A_1 5zsi_A_1_B_1 5zsi_B_1_A_1 5zsj_A_1_B_1 5zsj_B_1_A_1 5zsl_A_1_B_1 5zsl_B_1_A_1 5zsm_A_1_B_1 5zsm_B_1_A_1 5zsn_A_1_B_1 5zsn_B_1_A_1 6if5_A_1_B_1 6if5_B_1_A_1 6lvx_A_1_B_1 6lvx_B_1_A_1 6lvy_A_1_B_1 6lvy_B_1_A_1 6lvz_A_1_B_1 6lvz_B_1_A_1 6lw0_A_1_B_1 6lw0_B_1_A_1 8s9h_A_1_B_1 8s9h_B_1_A_1 8tty_A_1_B_1 8tty_B_1_A_1 [99299:TLR8_HUMAN ] 6wml_D_1_C_1 compound [C09 ] 3w3j_A_1_M_1 3w3j_B_1_V_1 5zsi_A_1_J_1 5zsi_B_1_R_1 [L07 ] 3w3k_A_1_I_1 3w3k_B_1_M_1 5zsh_A_1_R_1 5zsh_B_1_S_1 [RX8 ] 3w3l_A_1_KA_1 3w3l_B_1_AA_1 3w3l_C_1_EA_1 3w3l_D_1_JA_1 3w3m_A_1_E_2 3w3m_A_2_E_1 3w3n_A_1_O_1 3w3n_B_1_Q_1 5gmh_A_1_F_1 5gmh_B_1_EA_1 [D80 ] 4qbz_A_1_O_1 4qbz_B_1_P_1 [XG1 ] 4qc0_A_1_J_1 4qc0_B_1_K_1 [URI ] 4r07_A_1_X_1 4r07_B_1_Q_1 4r07_C_1_KA_1 4r07_D_1_EA_1 4r08_A_1_X_1 4r08_B_1_Q_1 4r08_C_1_KA_1 4r08_D_1_FA_1 4r09_A_1_T_1 4r09_B_1_P_1 4r09_C_1_AA_1 4r09_D_1_Z_1 4r0a_A_1_E_2 4r0a_A_2_E_1 [HB2 ] 4r6a_A_1_M_1 4r6a_B_1_N_1 [M8D ] 5awa_A_1_E_2 5awa_A_2_E_1 [M0A ] 5awb_A_1_E_2 5awb_A_2_E_1 [M4D ] 5awc_A_1_T_1 5awc_B_1_U_1 5awc_C_1_Z_1 5awc_D_1_AA_1 [IDQ ] 5awd_A_1_E_2 5awd_A_2_E_1 5zsa_A_1_P_1 5zsa_B_1_Y_1 5zsb_A_1_P_1 5zsb_B_1_BA_1 5zsc_A_1_P_1 5zsc_B_1_CA_1 5zsd_A_1_P_1 5zsd_B_1_CA_1 5zse_A_1_O_1 5zse_B_1_FA_1 [MBL ] 5az5_A_1_U_1 5az5_B_1_Q_1 5az5_C_1_EA_1 5az5_D_1_Z_1 [GMP ] 5gmf_A_1_Y_1 5gmf_B_1_S_1 5gmf_C_1_Z_1 5gmf_D_1_GA_1 [SDL ] 5gmg_A_1_J_1 5gmg_B_1_K_1 [6T0 ] 5zsf_A_1_O_1 5zsf_B_1_U_1 [9K3 ] 5zsg_A_1_M_1 5zsg_B_1_X_1 [9JR ] 5zsj_A_1_E_1 5zsj_B_1_V_1 [9K9 ] 5zsl_A_1_T_1 5zsl_B_1_U_1 5zsm_A_1_DA_1 5zsm_B_1_R_1 [ACK ] 5zsn_A_1_GA_1 5zsn_B_1_Z_1 [23G ] 6if5_A_1_FA_1 6if5_B_1_GA_1 [EWL ] 6lvx_A_1_D_1 6lvx_B_1_P_1 [EWU ] 6lvy_A_1_E_1 6lvy_B_1_S_1 [EWX ] 6lvz_A_1_S_1 6lvz_B_1_T_1 [EX0 ] 6lw0_A_1_CA_1 6lw0_B_1_S_1 [U57 ] 6wml_A_1_X_1 6wml_B_1_GA_1 6wml_C_1_NA_1 6wml_D_1_TA_1 [ZWV ] 8s9h_A_1_N_1 8s9h_B_1_W_1 [QEC ] 8tty_A_1_N_1 8tty_B_1_V_1 [QCX ] 8ttz_A_1_EA_1 8ttz_B_2_GA_2 precipitant [SO4 ] 3w3j_A_1_O_1 3w3j_B_1_AA_1


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