Summary for the 494-th Site(F) |
PID | QueryLength | FocusSite | TITLE |
2684896 | 1041 | 494 F | RecName: Full=Toll-like receptor 8 ;AltName: CD_antigen=CD288;Flags: Precursor; |
AC/ID | AC:Q9NR97 ID:TLR8_HUMAN |
Feature Table for 494-th site |
VARIANT: /note="F -> L (in IMD98; gain-of-function variant resulting in increased NF-kappa-B activation measured in a reporter assay)" /id="VAR_087089" REPEAT: /note="LRR 13" TOPO_DOM: /note="Extracellular" CHAIN: /note="Toll-like receptor 8" /id="PRO_0000034735" |
VARIANT for 494-th site |
F->L LP/P " Immunodeficiency 98 with autoinflammation, X-linked (IMD98) " [MIM:301078] |
Percentages of Amino Acids in Homologous Proteins [show alignment] |
S:19% T:14% F:9% R:6% G:6% L:6% E:5% K:5% V:5% A:4% N:4% I:4% Q:3% H:3% P:3% D:2% M:1% Y:1% |
Template For Monomer | predicted SecStr | predicted ExpBur | Predicted Relative Acc(%) |
4qbz | (coil) | e (exposed) | 55.5 |
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