Summary for the 572-nd Site(G) |
PID | QueryLength | FocusSite | TITLE |
2684896 | 1041 | 572 G | RecName: Full=Toll-like receptor 8 ;AltName: CD_antigen=CD288;Flags: Precursor; |
AC/ID | AC:Q9NR97 ID:TLR8_HUMAN |
Feature Table for 572-th site |
VARIANT: /note="G -> D (in IMD98; gain-of-function variant resulting in increased NF-kappa-B activation measured in a reporter assay; dbSNP:rs1385657144)" /id="VAR_087090" VARIANT: /note="G -> V (in IMD98; increased NF-kappa-B activation measured in a reporter assay; results in increased TLR8 protein degradation)" /id="VAR_087091" TURN: REPEAT: /note="LRR 16" TOPO_DOM: /note="Extracellular" CHAIN: /note="Toll-like receptor 8" /id="PRO_0000034735" |
VARIANT for 572-th site |
G->D LP/P dbSNP:rs1385657 " Immunodeficiency 98 with autoinflammation, X-linked (IMD98) " [MIM:301078] G->V LP/P " Immunodeficiency 98 with autoinflammation, X-linked (IMD98) " [MIM:301078] |
Percentages of Amino Acids in Homologous Proteins [show alignment] |
G:31% A:10% E:8% S:8% K:6% R:5% N:4% P:4% C:3% Q:3% T:3% V:3% D:2% H:2% I:2% L:2% F:2% M:1% Y:1% |
Template For Monomer | predicted SecStr | predicted ExpBur | Predicted Relative Acc(%) |
4qbz | T (Hbond turn) | e (exposed) | 91.7 |
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