type start end name pdb_id identity asym_id_homo oper_homo auth_asym_id_homo mol_id_homo asym_id_con oper_con auth_asym_id_con mol_id_con sites description_homo description_con length 1 492 id 1 492 TMPS2_HUMAN title 1 492 RecName: Full=Transmembrane protease serine 2 ; EC=3.4.21.122 ;AltName: Full=Serine protease 10 ;Contains: RecName: Full=Transmembrane protease serine 2 non-catalytic chain;Contains: RecName: Full=Transmembrane protease serine 2 catalytic chain;Flags: Precursor; seq 1 492 MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRADG uniprot 1 255 CHAIN /note="Transmembrane protease serine 2 non-catalytic chain" /id="PRO_0000027855" uniprot 256 492 CHAIN /note="Transmembrane protease serine 2 catalytic chain" /id="PRO_0000027856" uniprot 1 84 TOPO_DOM /note="Cytoplasmic" uniprot 85 105 TRANSMEM /note="Helical; Signal-anchor for type II membrane protein" uniprot 106 492 TOPO_DOM /note="Extracellular" uniprot 112 149 DOMAIN /note="LDL-receptor class A" uniprot 150 242 DOMAIN /note="SRCR" uniprot 256 489 DOMAIN /note="Peptidase S1" uniprot 296 296 ACT_SITE /note="Charge relay system" uniprot 345 345 ACT_SITE /note="Charge relay system" uniprot 441 441 ACT_SITE /note="Charge relay system" disorder 1 36 predicted_by_DISOPRED disorder 52 52 predicted_by_DISOPRED disorder 54 55 predicted_by_DISOPRED disorder 57 65 predicted_by_DISOPRED disorder 67 67 predicted_by_DISOPRED disorder 69 69 predicted_by_DISOPRED disorder 492 492 predicted_by_DISOPRED pdb_monomer 131 491 monomer 8vgt 99.4 B B TMPS2_HUMAN 131-248:250-491 pdb_monomer 113 249 monomer 8hd8 100.0 C B TMPS2_HUMAN 113-249 pdb_complex 131 491 hetero 8vgt 99.4 B 1 B TMPS2_HUMAN A 1 A SPIKE_CVHN1 341:409:413-417:419:430:431:461:463:468-470 Transmembrane protease serine 2 Spike protein S1[280 aa] pdb_complex 117 249 hetero 7xyd 100.0 A 1 A TMPS2_HUMAN B 1 C TMPS2_HUMAN 143:145-147:150-156:186-191:240:242-248 Transmembrane protease serine 2 catalytic chain Transmembrane protease serine 2 catalytic chain[24.. pdb_complex 148 250 hetero 8v04 100.0 A 1 A TMPS2_HUMAN B 1 B TMPS2_HUMAN 150-156:186-191:240:242-248 Transmembrane protease serine 2 non-catalytic chai.. Transmembrane protease serine 2[238 aa] pdb_complex 256 492 hetero 7xyd 100.0 B 1 C TMPS2_HUMAN A 1 A TMPS2_HUMAN 264-266:268:269:286:287:289:362-366:368-371:450:452-454:482:485:486:488:489 Transmembrane protease serine 2 catalytic chain Transmembrane protease serine 2 catalytic chain[12.. pdb_complex 256 492 hetero 7xyd 100.0 D 1 D TMPS2_HUMAN C 1 B TMPS2_HUMAN 265:266:268:269:286-289:359:362-366:368-370:449-454:482:485:486:488:489:492 Transmembrane protease serine 2 catalytic chain Transmembrane protease serine 2 catalytic chain[12.. pdb_complex 256 492 hetero 7y0e 100.0 D 1 D TMPS2_HUMAN C 1 B TMPS2_HUMAN 265:266:268:286-288:290:357:362-366:368-370:448:450-454:482:485:486:488:489:491:492 Transmembrane protease serine 2 catalytic chain Transmembrane protease serine 2 catalytic chain[13.. pdb_complex 142 492 hetero 8jhz 100.0 B 1 B TMPS2_HUMAN A 1 A M9ZTT7_PAESO 276:278:280:296:297:299:302:322:340:342:416:417:419:461-463:470 Transmembrane protease serine 2 Hemorrhagic toxin[2615 aa] pdb_complex 142 492 hetero 8ji0 100.0 A 1 B TMPS2_HUMAN B 1 A MALE_ECOLI:M9ZTT7_PAESO 276:278:280:296:297:299:302:322:340:342:416:417:419:461-463:470 Transmembrane protease serine 2 Maltose/maltodextrin-binding periplasmic protein,H.. pdb_complex 256 492 hetero 8v04 100.0 B 1 B TMPS2_HUMAN A 1 A TMPS2_HUMAN 263-266:268:269:286:287:362-366:368-370:450:452-454:485:488:489:491 Transmembrane protease serine 2 Transmembrane protease serine 2 non-catalytic chai.. pdb_complex 148 491 compound 7meq 100.0 A 1 A TMPS2_HUMAN C 1 A GBS 435-441:459:461:462:464:470-472 Transmembrane protease serine 2 4-carbamimidamidobenzoic acid[12 atoms] pdb_complex 256 492 compound 7xyd 100.0 B 1 C TMPS2_HUMAN G 1 C GBS 435-439:441:459-462:464:472 Transmembrane protease serine 2 catalytic chain 4-carbamimidamidobenzoic acid[12 atoms] pdb_complex 117 249 compound 7xyd 100.0 A 1 A TMPS2_HUMAN E 1 A NAG 213:215:226 Transmembrane protease serine 2 catalytic chain 2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms].. pdb_complex 256 492 compound 7y0f 100.0 B 1 C TMPS2_HUMAN G 1 C I9V 296:389:390:435-438:441:459-465:470-472 Transmembrane protease serine 2 catalytic chain 2-[(1-carbamimidamido-4-chloranyl-isoquinolin-7-yl.. pdb_complex 148 250 compound 8v1f 100.0 A 1 A TMPS2_HUMAN G 1 A TAM 177:179:180:218:219:224 Transmembrane protease serine 2 non-catalytic chai.. TRIS(HYDROXYETHYL)AMINOMETHANE[11 atoms] pdb_complex 256 492 compound 8v1f 100.0 B 1 B TMPS2_HUMAN N 1 B TAM 280:296:297:438:439:441 Transmembrane protease serine 2 TRIS(HYDROXYETHYL)AMINOMETHANE[11 atoms] pdb_complex 256 492 compound 8v1f 100.0 B 1 B TMPS2_HUMAN P 1 B TAM 313-316:319 Transmembrane protease serine 2 TRIS(HYDROXYETHYL)AMINOMETHANE[11 atoms] pdb_complex 256 492 compound 8v1f 100.0 B 1 B TMPS2_HUMAN O 1 B 7R8 435-438:441:461:462:464:465:472 Transmembrane protease serine 2 6-oxidanylnaphthalene-2-carboximidamide[14 atoms] pdb_complex 148 491 metal 7meq 100.0 A 1 A TMPS2_HUMAN D 1 A UNX 315:316 Transmembrane protease serine 2 UNKNOWN ATOM OR ION[1 atoms] pdb_complex 148 491 metal 7meq 100.0 A 1 A TMPS2_HUMAN E 1 A UNX 325 Transmembrane protease serine 2 UNKNOWN ATOM OR ION[1 atoms] pdb_complex 148 250 metal 8v04 100.0 A 1 A TMPS2_HUMAN E 1 A UNX 148 Transmembrane protease serine 2 non-catalytic chai.. UNKNOWN ATOM OR ION[1 atoms] pdb_complex 148 250 metal 8v1f 100.0 A 1 A TMPS2_HUMAN H 1 A UNX 151:190 Transmembrane protease serine 2 non-catalytic chai.. UNKNOWN ATOM OR ION[1 atoms] pdb_complex 256 492 metal 8v1f 100.0 B 1 B TMPS2_HUMAN H 1 A UNX 485 Transmembrane protease serine 2 UNKNOWN ATOM OR ION[1 atoms] pdb_complex 148 250 metal 8v1f 100.0 C 1 C TMPS2_HUMAN Z 1 C UNX 219:220:224 Transmembrane protease serine 2 non-catalytic chai.. UNKNOWN ATOM OR ION[1 atoms] pdb_complex 117 249 metal 7xyd 100.0 A 1 A TMPS2_HUMAN F 1 A CA 131:134:136:138:144:145 Transmembrane protease serine 2 catalytic chain CALCIUM ION[1 atoms] pdb_complex 256 492 metal 8v04 100.0 B 1 B TMPS2_HUMAN J 1 B CA 303 Transmembrane protease serine 2 CALCIUM ION[1 atoms] pdb_complex 148 491 otherpoly 7meq 100.0 A 1 A TMPS2_HUMAN B 1 B 213:215:226 Transmembrane protease serine 2 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. pdb_complex 148 250 otherpoly 8v1f 100.0 A 1 A TMPS2_HUMAN E 1 E 213:215:226 Transmembrane protease serine 2 non-catalytic chai.. 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. pdb_complex 131 491 otherpoly 8vgt 99.4 B 1 B TMPS2_HUMAN C 1 C 213:226 Transmembrane protease serine 2 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. pdb_complex 148 250 otherpoly 8v04 100.0 A 1 A TMPS2_HUMAN C 1 C 213:215:216:219:223:226 Transmembrane protease serine 2 non-catalytic chai.. 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. pdb_complex 148 250 otherpoly 8v1f 100.0 C 1 C TMPS2_HUMAN F 1 F 213:215-217:219:226 Transmembrane protease serine 2 non-catalytic chai.. 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al.. pdb_complex 256 492 precipitant 7y0e 100.0 D 1 D TMPS2_HUMAN K 1 D GOL 263-268:270:313-315:360:397 Transmembrane protease serine 2 catalytic chain GLYCEROL[6 atoms] pdb_complex 148 250 precipitant 8v04 100.0 A 1 A TMPS2_HUMAN D 1 A EDO 226 Transmembrane protease serine 2 non-catalytic chai.. 1,2-ETHANEDIOL[4 atoms] pdb_complex 148 250 precipitant 8v04 100.0 A 1 A TMPS2_HUMAN F 1 A EDO 215 Transmembrane protease serine 2 non-catalytic chai.. 1,2-ETHANEDIOL[4 atoms] pdb_complex 148 250 precipitant 8v04 100.0 A 1 A TMPS2_HUMAN L 1 B EDO 187:188 Transmembrane protease serine 2 non-catalytic chai.. 1,2-ETHANEDIOL[4 atoms] pdb_complex 256 492 precipitant 8v04 100.0 B 1 B TMPS2_HUMAN K 1 B EDO 264:313:315:360 Transmembrane protease serine 2 1,2-ETHANEDIOL[4 atoms] pdb_complex 256 492 precipitant 8v04 100.0 B 1 B TMPS2_HUMAN L 1 B EDO 482:485:486:489 Transmembrane protease serine 2 1,2-ETHANEDIOL[4 atoms] pdb_complex 256 492 precipitant 8v04 100.0 B 1 B TMPS2_HUMAN O 1 B EDO 414 Transmembrane protease serine 2 1,2-ETHANEDIOL[4 atoms] pdb_complex 256 492 precipitant 8v04 100.0 B 1 B TMPS2_HUMAN P 1 B EDO 331:332 Transmembrane protease serine 2 1,2-ETHANEDIOL[4 atoms] pdb_complex 148 250 precipitant 8v1f 100.0 A 1 A TMPS2_HUMAN I 1 A EDO 192 Transmembrane protease serine 2 non-catalytic chai.. 1,2-ETHANEDIOL[4 atoms] pdb_complex 148 250 precipitant 8v1f 100.0 A 1 A TMPS2_HUMAN M 1 B EDO 189-191:193 Transmembrane protease serine 2 non-catalytic chai.. 1,2-ETHANEDIOL[4 atoms] pdb_complex 148 250 precipitant 8v1f 100.0 A 1 A TMPS2_HUMAN T 1 B EDO 247 Transmembrane protease serine 2 non-catalytic chai.. 1,2-ETHANEDIOL[4 atoms] pdb_complex 256 492 precipitant 8v1f 100.0 B 1 B TMPS2_HUMAN L 1 B EDO 370:372 Transmembrane protease serine 2 1,2-ETHANEDIOL[4 atoms] pdb_complex 256 492 precipitant 8v1f 100.0 B 1 B TMPS2_HUMAN M 1 B EDO 287-290:488 Transmembrane protease serine 2 1,2-ETHANEDIOL[4 atoms] pdb_complex 256 492 precipitant 8v1f 100.0 B 1 B TMPS2_HUMAN Q 1 B EDO 391-393 Transmembrane protease serine 2 1,2-ETHANEDIOL[4 atoms] pdb_complex 256 492 precipitant 8v1f 100.0 B 1 B TMPS2_HUMAN R 1 B EDO 274:277:309:311:320-322 Transmembrane protease serine 2 1,2-ETHANEDIOL[4 atoms] pdb_complex 256 492 precipitant 8v1f 100.0 B 1 B TMPS2_HUMAN S 1 B EDO 340-342:419:461 Transmembrane protease serine 2 1,2-ETHANEDIOL[4 atoms] pdb_complex 256 492 precipitant 8v1f 100.0 B 1 B TMPS2_HUMAN T 1 B EDO 267:453 Transmembrane protease serine 2 1,2-ETHANEDIOL[4 atoms] pdb_complex 256 492 precipitant 8v1f 100.0 B 1 B TMPS2_HUMAN V 1 B EDO 429:431-434 Transmembrane protease serine 2 1,2-ETHANEDIOL[4 atoms] pdb_complex 148 250 precipitant 8v1f 100.0 C 1 C TMPS2_HUMAN AA 1 C EDO 193:242:243 Transmembrane protease serine 2 non-catalytic chai.. 1,2-ETHANEDIOL[4 atoms] pdb_complex 256 492 precipitant 8v1f 100.0 D 1 D TMPS2_HUMAN IA 1 D EDO 378:380:447:448:453 Transmembrane protease serine 2 1,2-ETHANEDIOL[4 atoms] pdb_complex 256 492 precipitant 8v1f 100.0 D 1 D TMPS2_HUMAN MA 1 D EDO 463:467:470 Transmembrane protease serine 2 1,2-ETHANEDIOL[4 atoms] pdb_complex 256 492 precipitant 8v04 100.0 B 1 B TMPS2_HUMAN I 1 B CIT 431-433 Transmembrane protease serine 2 CITRIC ACID[13 atoms] pdb_complex 148 250 precipitant 8v1f 100.0 C 1 C TMPS2_HUMAN CA 1 C CIT 247:249 Transmembrane protease serine 2 non-catalytic chai.. CITRIC ACID[13 atoms] pdb_complex 148 250 precipitant 8v1f 100.0 C 1 C TMPS2_HUMAN Y 1 C CIT 220:222:223 Transmembrane protease serine 2 non-catalytic chai.. CITRIC ACID[13 atoms] pdb_complex 256 492 precipitant 8v1f 100.0 D 1 D TMPS2_HUMAN CA 1 C CIT 266:267:380:453 Transmembrane protease serine 2 CITRIC ACID[13 atoms] pdb_complex 256 492 precipitant 8v04 100.0 B 1 B TMPS2_HUMAN N 1 B PG4 340-342:419:421:424:461 Transmembrane protease serine 2 TETRAETHYLENE GLYCOL[13 atoms] pdb_complex 148 250 precipitant 8v1f 100.0 C 1 C TMPS2_HUMAN BA 1 C PG4 155:156:198:200:238:240 Transmembrane protease serine 2 non-catalytic chai.. TETRAETHYLENE GLYCOL[13 atoms] pdb_complex 256 492 precipitant 8v1f 100.0 D 1 D TMPS2_HUMAN BA 1 C PG4 450:452 Transmembrane protease serine 2 TETRAETHYLENE GLYCOL[13 atoms] pdb_complex 256 492 precipitant 8v1f 100.0 D 1 D TMPS2_HUMAN JA 1 D PG4 375:376:403-406:409:428-431 Transmembrane protease serine 2 TETRAETHYLENE GLYCOL[13 atoms] pdb_complex 148 250 precipitant 8v1f 100.0 C 1 C TMPS2_HUMAN X 1 C PEG 183:186:187 Transmembrane protease serine 2 non-catalytic chai.. DI(HYDROXYETHYL)ETHER[7 atoms]