type start end name pdb_id identity asym_id_homo oper_homo auth_asym_id_homo mol_id_homo asym_id_con oper_con auth_asym_id_con mol_id_con sites description_homo description_con length 1 425 id 1 425 SMAD3_HUMAN title 1 425 RecName: Full=Mothers against decapentaplegic homolog 3; Short=MAD homolog 3; Short=Mad3; Short=Mothers against DPP homolog 3; Short=hMAD-3;AltName: Full=JV15-2;AltName: Full=SMAD family member 3; Short=SMAD 3; Short=Smad3; Short=hSMAD3; seq 1 425 MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS uniprot 2 425 CHAIN /note="Mothers against decapentaplegic homolog 3" /id="PRO_0000090856" uniprot 10 136 DOMAIN /note="MH1" uniprot 232 425 DOMAIN /note="MH2" uniprot 137 231 REGION /note="Linker" uniprot 165 208 REGION /note="Disordered" uniprot 271 324 REGION /note="Sufficient for interaction with XPO4" uniprot 64 64 BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" uniprot 109 109 BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" uniprot 121 121 BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" uniprot 126 126 BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" disorder 1 9 predicted_by_DISOPRED disorder 172 212 predicted_by_DISOPRED disorder 215 215 predicted_by_DISOPRED disorder 418 425 predicted_by_DISOPRED pdb_monomer 220 416 monomer 1mk2 100.0 A A SMAD3_HUMAN 220-416 pdb_monomer 7 132 monomer 1ozj 100.0 C A SMAD3_HUMAN 7-132 pdb_complex 220 414 hetero 5xod 97.4 A 1 A SMAD2_HUMAN B 1 B SKI_HUMAN 226:228:298:300:301:303:343:345:346:348:349:352:353:356:402:405:406:409:410:413 Mothers against decapentaplegic homolog 2 Ski oncogene[22 aa] pdb_complex 224 424 hetero 6zvq 96.5 A 1 A SMAD2_HUMAN B 1 B SKI_HUMAN 226-228:232:298:300:301:303:345:346:348:349:352:353:402:405:406:409:410:413 Mothers against decapentaplegic homolog 2 Ski oncogene[27 aa] pdb_complex 228 424 hetero 1u7f 100.0 A 1 A SMAD3_HUMAN B 1 B SMAD4_HUMAN 238:241:243:246:247:360:364:367:390:395:397:399:401:404:405:407:408:411:412:416:417:419-424 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 4[193 aa] pdb_complex 230 424 hetero 1u7f 100.0 C 1 C SMAD3_HUMAN B 1 B SMAD4_HUMAN 246:259-265:268:272:273:275-279:284:287:288:310 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 4[193 aa] pdb_complex 224 415 hetero 7co1 97.4 E 1 E SMAD2_HUMAN F 1 F CBP_HUMAN 298:300:301:345:346:349:350:352:353:356:406:410:413:414 Mothers against decapentaplegic homolog 2 CREB-binding protein[18 aa] pdb_complex 224 416 hetero 6m64 97.4 E 1 E SMAD2_HUMAN F 1 F 298:300:301:345:346:349:350:352:353:356:357:406:409:410:413:414 Mothers against decapentaplegic homolog 2 CBP[27 aa] pdb_complex 223 416 hetero 7co1 97.4 A 1 A SMAD2_HUMAN B 1 B CBP_HUMAN 301:345:346:349:350:353:356:357:406:409:413:414 Mothers against decapentaplegic homolog 2 CREB-binding protein[20 aa] pdb_complex 223 424 hetero 6m64 96.0 A 1 A SMAD2_HUMAN B 1 B 346:349:350:353:356:357:406:409:410:413:414 Mothers against decapentaplegic homolog 2 CBP[19 aa] pdb_complex 230 414 hetero 5zoj 97.8 B 1 B SMAD2_HUMAN E 1 E MAN1_HUMAN 324:326:327:330-336:338-340:382:383 Mothers against decapentaplegic homolog 2 Inner nuclear membrane protein Man1[116 aa] pdb_complex 228 414 hetero 5zoj 97.9 A 1 A SMAD2_HUMAN D 1 D MAN1_HUMAN 326:327:330-333:335:338-340:382:383 Mothers against decapentaplegic homolog 2 Inner nuclear membrane protein Man1[127 aa] pdb_complex 221 414 hetero 1dev 97.4 A 1 A SMAD2_HUMAN B 1 B ZFYV9_HUMAN 221-226:297:299:300:304:324:326:330:332-335:337-340:345:349:352:353:356:360:406:410:413:414 MAD (mothers against decapentaplegic, Drosophila) .. Smad anchor for receptor activation[41 aa] pdb_complex 221 414 hetero 5xoc 100.0 A 1 A SMAD3_HUMAN B 1 B THIO_ECOLI:FOXH1_HUMAN 316:324:326-333:335:338-340:351:355:358:362:365:368:380-384:387 Mothers against decapentaplegic homolog 3 Thioredoxin 1,Forkhead box protein H1[133 aa] pdb_complex 11 134 nucleotide 5od6 100.0 A 1 A SMAD3_HUMAN C 1 C 40:74:81:100:101 Mothers against decapentaplegic homolog 3 DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*GP*CP*GP*CP*CP*TP.. pdb_complex 11 134 nucleotide 5od6 100.0 A 1 A SMAD3_HUMAN D 1 D 70:71:74-79:81 Mothers against decapentaplegic homolog 3 DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*GP*CP*GP*CP*CP*TP.. pdb_complex 10 132 nucleotide 1mhd 100.0 C 1 A SMAD3_HUMAN A 1 C 33:37:70:71:75-78:81 SMAD3 DNA pdb_complex 10 132 nucleotide 1mhd 100.0 C 1 A SMAD3_HUMAN B 1 D 74:81:100:101 SMAD3 DNA pdb_complex 10 132 nucleotide 1mhd 100.0 D 1 B SMAD3_HUMAN B 1 D 37:70:71:75:76:78:81 SMAD3 DNA pdb_complex 7 132 nucleotide 1ozj 100.0 C 1 A SMAD3_HUMAN A 1 C 33:37:70:71:74-78:81 SMAD 3 Smad binding element pdb_complex 7 132 nucleotide 1ozj 100.0 C 1 A SMAD3_HUMAN B 1 D 40:74:76:81:100:101 SMAD 3 Smad binding element pdb_complex 11 135 nucleotide 5odg 100.0 A 1 A SMAD3_HUMAN C 1 D 70:71:74-78:81 Mothers against decapentaplegic homolog 3 DNA (5'-D(P*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP.. pdb_complex 11 135 nucleotide 5odg 100.0 A 1 A SMAD3_HUMAN D 1 E 74:76:81:100:101 Mothers against decapentaplegic homolog 3 DNA (5'-D(P*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP.. pdb_complex 224 424 compound 6zvq 96.5 A 1 A SMAD2_HUMAN I 1 A TAR 339:340 Mothers against decapentaplegic homolog 2 D(-)-TARTARIC ACID[10 atoms] pdb_complex 224 424 compound 6zvq 96.5 A 1 A SMAD2_HUMAN J 1 A TAR 367:368:371:373 Mothers against decapentaplegic homolog 2 D(-)-TARTARIC ACID[10 atoms] pdb_complex 224 424 compound 6zvq 96.5 A 1 A SMAD2_HUMAN J 2 A TAR 272-275:279:287 Mothers against decapentaplegic homolog 2 D(-)-TARTARIC ACID[10 atoms] pdb_complex 224 424 compound 6zvq 96.5 A 1 A SMAD2_HUMAN O 1 A TAR 231:247-249 Mothers against decapentaplegic homolog 2 D(-)-TARTARIC ACID[10 atoms] pdb_complex 7 132 metal 1ozj 100.0 C 1 A SMAD3_HUMAN E 1 A ZN 64:109:121:126 SMAD 3 ZINC ION[1 atoms] pdb_complex 11 134 metal 5od6 100.0 A 1 A SMAD3_HUMAN E 1 A ZN 64:109:121:126 Mothers against decapentaplegic homolog 3 ZINC ION[1 atoms] pdb_complex 10 132 metal 6zmn 96.7 A 1 A SMAD3_HUMAN G 1 A ZN 64:109:121:126 Mothers against decapentaplegic homolog 3 ZINC ION[1 atoms] pdb_complex 11 135 metal 5odg 100.0 A 1 A SMAD3_HUMAN F 1 A CL 64 Mothers against decapentaplegic homolog 3 CHLORIDE ION[1 atoms] pdb_complex 7 132 homo 1ozj 100.0 C 1 A SMAD3_HUMAN D 1 B SMAD3_HUMAN 79 SMAD 3 SMAD 3[124 aa] pdb_complex 11 134 homo 5od6 100.0 A 1 A SMAD3_HUMAN B 1 B SMAD3_HUMAN 129-132:134 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 3[126 aa] pdb_complex 10 132 homo 6zmn 96.7 A 1 A SMAD3_HUMAN B 1 B SMAD3_HUMAN 11:12:14-16:18-22:28:31:32:35:36:39:48:51:52:55:56:58:91-93:95 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 3[119 aa] pdb_complex 223 424 homo 1khx 96.5 A 1 A SMAD2_HUMAN A 2 A SMAD2_HUMAN 246:260-265:268:272:273:275:277:278:284:285:287-289:310:314:333:377-379:384-386 Smad2 Smad2[203 aa] pdb_complex 223 424 homo 1khx 96.5 A 1 A SMAD2_HUMAN A 3 A SMAD2_HUMAN 225-227:229:241:247:249:360:364:365:367:373:390:395:397:399:401:404:405:407:408:411:412:416:417:419:421-424 Smad2 Smad2[203 aa] pdb_complex 220 416 homo 1mk2 100.0 A 1 A SMAD3_HUMAN A 2 A SMAD3_HUMAN 316:325-329:361:364:380-382:387 SMAD 3 SMAD 3[197 aa] pdb_complex 228 424 homo 1u7f 100.0 A 1 A SMAD3_HUMAN C 1 C SMAD3_HUMAN 246:260-264:268:273:275:277:278:287-289:310:311:333:377-379:384-386 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 3[196 aa] pdb_complex 230 424 homo 1u7f 100.0 C 1 C SMAD3_HUMAN A 1 A SMAD3_HUMAN 238:241:247:249:361:364:367:390:395:397:399:401:404:405:408:411:417:419-424 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 3[198 aa] pdb_complex 221 414 homo 5xoc 100.0 A 1 A SMAD3_HUMAN A 2 A SMAD3_HUMAN 229:238:241:247:249:364:367:390:395:397:399:401:404:407:408:411:412 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 3[194 aa] pdb_complex 228 414 homo 5zoj 97.9 A 1 A SMAD2_HUMAN C 1 C SMAD2_HUMAN 229:241:247:249:361:364:390:395:397:399:401:404:405:407-409:412 Mothers against decapentaplegic homolog 2 Mothers against decapentaplegic homolog 2[186 aa] pdb_complex 224 424 precipitant 6zvq 96.5 A 1 A SMAD2_HUMAN C 1 A SO4 358-361:416-418 Mothers against decapentaplegic homolog 2 SULFATE ION[5 atoms] pdb_complex 224 424 precipitant 6zvq 96.5 A 1 A SMAD2_HUMAN D 1 A SO4 316:380:387-389 Mothers against decapentaplegic homolog 2 SULFATE ION[5 atoms] pdb_complex 224 424 precipitant 6zvq 96.5 A 1 A SMAD2_HUMAN E 1 A GOL 246:262:263:268-270:273 Mothers against decapentaplegic homolog 2 GLYCEROL[6 atoms] pdb_complex 224 424 precipitant 6zvq 96.5 A 1 A SMAD2_HUMAN F 1 A GOL 275-277:279:284 Mothers against decapentaplegic homolog 2 GLYCEROL[6 atoms] pdb_complex 224 424 precipitant 6zvq 96.5 A 1 A SMAD2_HUMAN F 3 A GOL 373 Mothers against decapentaplegic homolog 2 GLYCEROL[6 atoms] pdb_complex 224 424 precipitant 6zvq 96.5 A 1 A SMAD2_HUMAN G 1 A GOL 254:295:297:306 Mothers against decapentaplegic homolog 2 GLYCEROL[6 atoms] pdb_complex 224 424 precipitant 6zvq 96.5 A 1 A SMAD2_HUMAN H 1 A GOL 264-266 Mothers against decapentaplegic homolog 2 GLYCEROL[6 atoms] pdb_complex 224 424 precipitant 6zvq 96.5 A 1 A SMAD2_HUMAN H 3 A GOL 227 Mothers against decapentaplegic homolog 2 GLYCEROL[6 atoms] pdb_complex 224 424 precipitant 6zvq 96.5 A 1 A SMAD2_HUMAN K 1 A GOL 228-232:298 Mothers against decapentaplegic homolog 2 GLYCEROL[6 atoms] pdb_complex 224 424 precipitant 6zvq 96.5 A 1 A SMAD2_HUMAN L 1 A GOL 245:273-275 Mothers against decapentaplegic homolog 2 GLYCEROL[6 atoms] pdb_complex 224 424 precipitant 6zvq 96.5 A 1 A SMAD2_HUMAN L 3 A GOL 236:238:243:397:399 Mothers against decapentaplegic homolog 2 GLYCEROL[6 atoms] pdb_complex 224 424 precipitant 6zvq 96.5 A 1 A SMAD2_HUMAN M 1 A GOL 326:330:331 Mothers against decapentaplegic homolog 2 GLYCEROL[6 atoms] pdb_complex 224 424 precipitant 6zvq 96.5 A 1 A SMAD2_HUMAN N 1 A GOL 337:339 Mothers against decapentaplegic homolog 2 GLYCEROL[6 atoms] pdb_complex 10 130 precipitant 6zmn 96.6 B 1 B SMAD3_HUMAN H 1 B PGE 17:18:20 Mothers against decapentaplegic homolog 3 TRIETHYLENE GLYCOL[10 atoms] pdb_complex 10 132 precipitant 6zmn 96.7 A 1 A SMAD3_HUMAN E 1 A ACT 47:64:66 Mothers against decapentaplegic homolog 3 ACETATE ION[4 atoms] pdb_complex 10 132 precipitant 6zmn 96.7 A 1 A SMAD3_HUMAN F 1 A EDO 46:47:50:63-65 Mothers against decapentaplegic homolog 3 1,2-ETHANEDIOL[4 atoms] pdb_complex 220 416 precipitant 1mk2 100.0 A 1 A SMAD3_HUMAN C 1 A ACY 318:321:327-329:368 SMAD 3 ACETIC ACID[4 atoms] pdb_complex 220 416 precipitant 1mk2 100.0 A 1 A SMAD3_HUMAN D 1 A ACY 316:373:380:387-389 SMAD 3 ACETIC ACID[4 atoms] pdb_complex 220 416 precipitant 1mk2 100.0 A 1 A SMAD3_HUMAN E 1 A ACY 383-385 SMAD 3 ACETIC ACID[4 atoms] pdb_complex 220 416 precipitant 1mk2 100.0 A 1 A SMAD3_HUMAN F 1 A ACY 248:249:265:266 SMAD 3 ACETIC ACID[4 atoms]