type start end name pdb_id identity asym_id_homo oper_homo auth_asym_id_homo mol_id_homo asym_id_con oper_con auth_asym_id_con mol_id_con sites description_homo description_con
length 1 1170
id 1 1170 ITAL_HUMAN
title 1 1170 RecName: Full=Integrin alpha-L ;AltName: Full=CD11 antigen-like family member A;AltName: Full=Leukocyte adhesion glycoprotein LFA-1 alpha chain; Short=LFA-1A;AltName: Full=Leukocyte function-associated molecule 1 alpha chain;AltName: CD_antigen=CD11a;Flags: Precursor;
seq 1 1170 MKDSCITVMAMALLSGFFFFAPASSYNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGAPGEGNSTGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTDGSILACDPGLSRTCDQNTYLSGLCYLFRQNLQGPMLQGRPGFQECIKGNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKRKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKFASKPASEFVKILDTFEKLKDLFTELQKKIYVIEGTSKQDLTSFNMELSSSGISADLSRGHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNEPLTPEVRAGYLGYTVTWLPSRQKTSLLASGAPRYQHMGRVLLFQEPQGGGHWSQVQTIHGTQIGSYFGGELCGVDVDQDGETELLLIGAPLFYGEQRGGRVFIYQRRQLGFEEVSELQGDPGYPLGRFGEAITALTDINGDGLVDVAVGAPLEEQGAVYIFNGRHGGLSPQPSQRIEGTQVLSGIQWFGRSIHGVKDLEGDGLADVAVGAESQMIVLSSRPVVDMVTLMSFSPAEIPVHEVECSYSTSNKMKEGVNITICFQIKSLIPQFQGRLVANLTYTLQLDGHRTRRRGLFPGGRHELRRNIAVTTSMSCTDFSFHFPVCVQDLISPINVSLNFSLWEEEGTPRDQRAQGKDIPPILRPSLHSETWEIPFEKNCGEDKKCEANLRVSFSPARSRALRLTAFASLSVELSLSNLEEDAYWVQLDLHFPPGLSFRKVEMLKPHSQIPVSCEELPEESRLLSRALSCNVSSPIFKAGHSVALQMMFNTLVNSSWGDSVELHANVTCNNEDSDLLEDNSATTIIPILYPINILIQDQEDSTLYVSFTPKGPKIHQVKHMYQVRIQPSIHDHNIPTLEAVVGVPQPPSEGPITHQWSVQMEPPVPCHYEDLERLPDAAEPCLPGALFRCPVVFRQEILVQVIGTLELVGEIEASSMFSLCSSLSISFNSSKHFHLYGSNASLAQVVMKVDVVYEKQMLYLYVLSGIGGLLLLLLIFIVLYKVGFFKRNLKEKMEAGRGVPNGIPAEDSEQLASGQEAGDPGCLKPLHEKDSESGGGKD
uniprot 1 25 SIGNAL
uniprot 26 1170 CHAIN /note="Integrin alpha-L" /id="PRO_0000016292"
uniprot 26 1090 TOPO_DOM /note="Extracellular"
uniprot 1091 1111 TRANSMEM /note="Helical"
uniprot 1112 1170 TOPO_DOM /note="Cytoplasmic"
uniprot 156 327 DOMAIN /note="VWFA"
uniprot 1128 1170 REGION /note="Disordered"
uniprot 1154 1170 COMPBIAS /note="Basic and acidic residues"
uniprot 468 468 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="1"
uniprot 470 470 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="1"
uniprot 472 472 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="1"
uniprot 476 476 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="1"
uniprot 530 530 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="2"
uniprot 532 532 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="2"
uniprot 534 534 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="2"
uniprot 538 538 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="2"
uniprot 590 590 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="3"
uniprot 594 594 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="3"
uniprot 598 598 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="3"
disorder 1 23 predicted_by_DISOPRED
disorder 738 746 predicted_by_DISOPRED
disorder 841 849 predicted_by_DISOPRED
disorder 988 988 predicted_by_DISOPRED
disorder 990 990 predicted_by_DISOPRED
disorder 992 1014 predicted_by_DISOPRED
disorder 1125 1170 predicted_by_DISOPRED
pdb_monomer 26 616 monomer 5e6u 99.8 A A ITAL_HUMAN 26-616
pdb_monomer 1113 1170 monomer 2k8o 98.3 A A ITAL_HUMAN 1113-1170
pdb_monomer 1082 1128 monomer 2m3e 100.0 A A ITAL_HUMAN 1082-1128
pdb_complex 153 325 hetero 1t0p 98.3 A 1 A ITAL_HUMAN B 1 B ICAM3_HUMAN 164-166:228-232:266-269:288:289 Integrin alpha-L Intercellular adhesion molecule-3[86 aa]
pdb_complex 154 332 hetero 3bn3 98.3 A 1 A ITAL_HUMAN B 1 B ICAM5_HUMAN 164-166:168:169:228-231:266:268:269:288:289:322:325:329 Integrin alpha-L Intercellular adhesion molecule 5[196 aa]
pdb_complex 153 331 hetero 3eoa 100.0 E 1 I ITAL_HUMAN A 1 L 169 Integrin alpha-L Efalizumab Fab fragment, light chain[214 aa]
pdb_complex 153 332 hetero 3hi6 98.3 A 1 A ITAL_HUMAN D 1 L 165:167-169:225-229 Integrin alpha-L light chain of Fab fragment of AL-57 against alpha..
pdb_complex 153 332 hetero 3hi6 98.3 A 1 A ITAL_HUMAN C 1 H 164-166:228-231:264:266-268:288:289:293:294:298 Integrin alpha-L Heavy chain of Fab fragment of AL-57 against alpha..
pdb_complex 155 331 hetero 1mq8 98.9 B 1 B ITAL_HUMAN A 1 A ICA1_HUMAN 164-166:168:200:229-232:266-270:289 Integrin alpha-L intercellular adhesion molecule-1[184 aa]
pdb_complex 154 332 hetero 3tcx 98.9 B 1 B ITAL_HUMAN A 1 A ICAM1_HUMAN 164-166:229-232:266:268-270:288:289 Integrin alpha-L Intercellular adhesion molecule 1[85 aa]
pdb_complex 26 615 hetero 5e6r 99.8 A 1 A ITAL_HUMAN B 1 B ITB2_HUMAN 43:44:47:48:61:63:93:94:97:118:120:121:123:341:345:349:354:368:373:403:406:426:429:430:455-457:459:484:486:518:520:580 Integrin alpha-L Integrin beta-2[454 aa]
pdb_complex 153 331 hetero 3eoa 100.0 E 1 I ITAL_HUMAN C 1 H 169:172:173:176:180:216:218:219:222-226:228 Integrin alpha-L Efalizumab Fab fragment, heavy chain[215 aa]
pdb_complex 26 615 compound 5e6r 99.8 A 1 A ITAL_HUMAN F 1 A NAG 87:89 Integrin alpha-L 2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms]..
pdb_complex 153 331 compound 6bxb 99.4 A 1 A ITB3_HUMAN:ITAL_HUMAN:ITB3_HUMAN E 1 A NAG 188 Chimera protein of Integrin beta-3 and Integrin al.. 2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms]..
pdb_complex 153 332 compound 3f78 99.4 A 1 A ITAL_HUMAN D 1 A ICF 260:282:284:312:323:326:327:330:332 Integrin alpha-L 1-CHLORO-2,2,2-TRIFLUOROETHYL DIFLUOROMETHYL ETHER..
pdb_complex 153 333 compound 1xuo 99.4 A 1 A ITAL_HUMAN D 1 A LA1 155:178:191:258:260:280:282:284:310:323:327:330:331:333 Integrin alpha-L (2R)-2-[3-ISOBUTYL-2,5-DIOXO-4-(QUINOLIN-3-YLMETHY..
pdb_complex 153 334 compound 1xdd 99.5 A 1 A ITAL_HUMAN D 1 A AAY 153:155:157:191:256:260:280:282:309:312:323:326:327:330:331 Integrin alpha-L 8-[2-((2S)-4-HYDROXY-1-{[5-(HYDROXYMETHYL)-6-METHO..
pdb_complex 153 334 compound 1xdg 99.5 A 1 A ITAL_HUMAN D 1 A AB8 157:260:280:282:309:310:312:323:326:327 Integrin alpha-L (1S,3R,8AS)-8-(2-{(4S,6S)-3-(4-HYDROXY-3-METHOXYBE..
pdb_complex 153 334 compound 3bqm 99.5 A 1 B ITAL_HUMAN C 1 B BQM 157:178:182:191:258:260:280:282-284:309-312:327 Integrin alpha-L 3-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-en-1-yl]-..
pdb_complex 153 334 compound 3bqm 99.5 A 1 B ITAL_HUMAN D 1 C BQM 333 Integrin alpha-L 3-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-en-1-yl]-..
pdb_complex 153 334 compound 3bqn 99.5 A 1 B ITAL_HUMAN C 1 B BQN 157:159:178:182:186:191:260:280:282-284:309:310:312:323:326:327:330 Integrin alpha-L 4-{(2E)-3-[4-{[2-(pyridin-3-ylmethoxy)phenyl]sulfa..
pdb_complex 153 334 compound 3bqn 99.5 A 1 B ITAL_HUMAN D 1 C BQN 333:334 Integrin alpha-L 4-{(2E)-3-[4-{[2-(pyridin-3-ylmethoxy)phenyl]sulfa..
pdb_complex 153 334 compound 3e2m 99.5 A 1 A ITAL_HUMAN C 1 A E2M 157:159:178:182:191:260:282-284:309-312:323:326:327:330 Integrin alpha-L cis-4-{[2-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-e..
pdb_complex 153 334 compound 3e2m 99.5 A 1 A ITAL_HUMAN D 1 B E2M 333:334 Integrin alpha-L cis-4-{[2-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-e..
pdb_complex 153 334 compound 4ixd 99.5 A 1 A ITAL_HUMAN C 1 A 1HV 191:258:260:282:284:323:326:327:330 Integrin alpha-L 4-(3-{4-[(3-aminopropyl)carbamoyl]phenyl}-1H-indaz..
pdb_complex 153 334 compound 4ixd 99.5 A 1 A ITAL_HUMAN C 2 A 1HV 333 Integrin alpha-L 4-(3-{4-[(3-aminopropyl)carbamoyl]phenyl}-1H-indaz..
pdb_complex 153 334 compound 1cqp 99.5 A 1 A ITAL_HUMAN D 1 A 803 157:258:260:282:312:323:326:327:330 ANTIGEN CD11A (P180) LOVASTATIN[29 atoms]
pdb_complex 153 334 compound 7kc6 100.0 A 1 C ITAL_HUMAN C 1 C 803 157:258:260:282:309:312:323:326:327 Integrin alpha-L LOVASTATIN[29 atoms]
pdb_complex 153 336 compound 1rd4 100.0 A 1 A ITAL_HUMAN E 1 A L08 157:159:178:182:191:258:260:280:282-284:309-312:323:326:327:330 Integrin alpha-L 1-ACETYL-4-(4-{4-[(2-ETHOXYPHENYL)THIO]-3-NITROPHE..
pdb_complex 154 331 compound 2ica 100.0 A 1 A ITAL_HUMAN B 1 A 2IC 159:182:186:191:258:260:280:282:284:312:327:331 Integrin alpha-L 5-[(5S,9R)-9-(4-CYANOPHENYL)-3-(3,5-DICHLOROPHENYL..
pdb_complex 154 332 compound 2o7n 100.0 A 1 A ITAL_HUMAN B 1 A 2O7 157:159:182:191:258:260:282:312:327:328:330:331 Integrin alpha-L 7A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-..
pdb_complex 154 332 compound 3m6f 100.0 A 1 A ITAL_HUMAN B 1 A BJZ 155:159:182:186:191:256:258:260:280:282:284:312:327:330:331 Integrin alpha-L 6-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl..
pdb_complex 153 334 compound 7kc5 100.0 A 1 A ITAL_HUMAN D 1 A BJZ 182:191:256:260:280:282:284:309:312:324:327:331 Integrin alpha-L 6-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl..
pdb_complex 153 335 metal 1lfa 100.0 A 1 A ITAL_HUMAN C 1 A MN 164:166:264 CD11A MANGANESE (II) ION[1 atoms]
pdb_complex 153 332 metal 3hi6 98.3 A 1 A ITAL_HUMAN G 1 A MN 164:166:231:264 Integrin alpha-L MANGANESE (II) ION[1 atoms]
pdb_complex 26 615 metal 5e6r 99.8 A 1 A ITAL_HUMAN D 1 A CA 468:470:472:474:476 Integrin alpha-L CALCIUM ION[1 atoms]
pdb_complex 26 615 metal 5e6r 99.8 A 1 A ITAL_HUMAN E 1 A CA 530:532:534:536:538 Integrin alpha-L CALCIUM ION[1 atoms]
pdb_complex 26 614 metal 5e6s 99.8 A 1 A ITAL_HUMAN J 1 A CA 590-592:594:596:598 Integrin alpha-L CALCIUM ION[1 atoms]
pdb_complex 153 331 metal 6bxb 99.4 A 1 A ITB3_HUMAN:ITAL_HUMAN:ITB3_HUMAN C 1 A CA 162:164:166:264 Chimera protein of Integrin beta-3 and Integrin al.. CALCIUM ION[1 atoms]
pdb_complex 153 335 metal 1lfa 100.0 A 1 A ITAL_HUMAN D 1 A CL 164-166 CD11A CHLORIDE ION[1 atoms]
pdb_complex 26 616 metal 5e6u 99.8 A 1 A ITAL_HUMAN F 1 A CL 164:166:231 Integrin alpha-L CHLORIDE ION[1 atoms]
pdb_complex 153 334 metal 1cqp 99.5 A 1 A ITAL_HUMAN C 1 A MG 164:166:231:264 ANTIGEN CD11A (P180) MAGNESIUM ION[1 atoms]
pdb_complex 26 615 metal 5e6r 99.8 A 1 A ITAL_HUMAN C 1 A MG 162:164:166:231:264 Integrin alpha-L MAGNESIUM ION[1 atoms]
pdb_complex 153 331 metal 6bxb 99.4 B 1 B ITB3_HUMAN:ITAL_HUMAN:ITB3_HUMAN H 1 B MG 162:164:166:231:264 Chimera protein of Integrin beta-3 and Integrin al.. MAGNESIUM ION[1 atoms]
pdb_complex 153 331 metal 6bxj 99.4 A 1 A ITB3_HUMAN:ITAL_HUMAN:ITB3_HUMAN C 1 A MG 214 Chimera protein of Integrin beta-3 and Integrin al.. MAGNESIUM ION[1 atoms]
pdb_complex 146 333 metal 7kc3 98.9 A 1 C ITAL_HUMAN B 1 C MG 162:164:166:264 Integrin alpha-L MAGNESIUM ION[1 atoms]
pdb_complex 153 331 metal 3eob 100.0 C 1 I ITAL_HUMAN G 1 I ZN 162:164:166:231:264:265 Integrin alpha-L ZINC ION[1 atoms]
pdb_complex 153 335 homo 1lfa 100.0 A 1 A ITAL_HUMAN B 1 B ITAL_HUMAN 168:169:225:226:228 CD11A CD11A[182 aa]
pdb_complex 153 334 homo 1lfa 100.0 B 1 B ITAL_HUMAN A 1 A ITAL_HUMAN 169:170:173:177:180:218:222 CD11A CD11A[183 aa]
pdb_complex 153 335 homo 1zoo 100.0 A 1 A ITAL_HUMAN B 1 B ITAL_HUMAN 153:184-191:309:310:327-335 LEUKOCYTE ADHESION GLYCOPROTEIN LEUKOCYTE ADHESION GLYCOPROTEIN[183 aa]
pdb_complex 26 614 homo 5e6s 99.8 A 1 A ITAL_HUMAN C 3 C ITAL_HUMAN 165:167:225:228 Integrin alpha-L Integrin alpha-L[578 aa]
pdb_complex 26 614 homo 5e6s 99.8 A 1 A ITAL_HUMAN E 2 E ITAL_HUMAN 202:230:232:234:235:238:242:243:246:248:268-272:274:275:278 Integrin alpha-L Integrin alpha-L[580 aa]
pdb_complex 26 615 homo 5e6s 99.8 C 3 C ITAL_HUMAN A 1 A ITAL_HUMAN 592:593:596:613-615 Integrin alpha-L Integrin alpha-L[579 aa]
pdb_complex 26 615 homo 5e6s 99.8 C 3 C ITAL_HUMAN E 2 E ITAL_HUMAN 103-106:133:134:360:362:414:415:441 Integrin alpha-L Integrin alpha-L[580 aa]
pdb_complex 153 332 precipitant 3hi6 98.3 B 1 B ITAL_HUMAN I 1 B SO4 222 Integrin alpha-L SULFATE ION[5 atoms]
pdb_complex 153 332 precipitant 3f74 99.4 B 1 B ITAL_HUMAN D 1 B GOL 238:271:272 Integrin alpha-L GLYCEROL[6 atoms]
pdb_complex 153 332 precipitant 3f78 99.4 A 1 A ITAL_HUMAN E 1 A GOL 300:307:308:311 Integrin alpha-L GLYCEROL[6 atoms]
pdb_complex 153 332 precipitant 3f78 99.4 B 1 B ITAL_HUMAN H 1 B GOL 230:232:268 Integrin alpha-L GLYCEROL[6 atoms]
pdb_complex 153 332 precipitant 3f78 99.4 C 1 C ITAL_HUMAN J 1 C GOL 280:304:305:310 Integrin alpha-L GLYCEROL[6 atoms]
pdb_complex 153 331 precipitant 6bxb 99.4 A 1 A ITB3_HUMAN:ITAL_HUMAN:ITB3_HUMAN G 1 A GOL 245:251-253:257 Chimera protein of Integrin beta-3 and Integrin al.. GLYCEROL[6 atoms]
pdb_complex 153 331 precipitant 6bxf 99.4 A 1 A ITB3_HUMAN:ITAL_HUMAN:ITB3_HUMAN C 1 A GOL 311-313 Chimera protein of Integrin beta-3 and Integrin al.. GLYCEROL[6 atoms]
pdb_complex 154 332 precipitant 3m6f 100.0 A 1 A ITAL_HUMAN C 1 A NO3 300:301:305 Integrin alpha-L NITRATE ION[4 atoms]