type start end name pdb_id identity asym_id_homo oper_homo auth_asym_id_homo mol_id_homo asym_id_con oper_con auth_asym_id_con mol_id_con sites description_homo description_con length 1 794 id 1 794 FURIN_HUMAN title 1 794 RecName: Full=Furin ; EC=3.4.21.75 ;AltName: Full=Dibasic-processing enzyme;AltName: Full=Paired basic amino acid residue-cleaving enzyme; Short=PACE;Flags: Precursor; seq 1 794 MELRPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQIFGDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTAPEGLPVPPESSGCKTLTSSQACVVCEEGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQGPALTDCLSCPSHASLDPVEQTCSRQSQSSRESPPQQQPPRLPPEVEAGQRLRAGLLPSHLPEVVAGLSCAFIVLVFVTVFLVLQLRSGFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEEDEGRGERTAFIKDQSAL uniprot 1 26 SIGNAL uniprot 27 107 PROPEP /note="Inhibition peptide" /id="PRO_0000027028" uniprot 108 794 CHAIN /note="Furin" /id="PRO_0000027029" uniprot 108 715 TOPO_DOM /note="Lumenal" uniprot 716 738 TRANSMEM /note="Helical" uniprot 739 794 TOPO_DOM /note="Cytoplasmic" uniprot 121 435 DOMAIN /note="Peptidase S8" uniprot 444 576 DOMAIN /note="P/Homo B" uniprot 162 183 REGION /note="Disordered" uniprot 673 696 REGION /note="Disordered" uniprot 759 762 REGION /note="Cell surface signal" uniprot 767 794 REGION /note="Disordered" uniprot 673 687 COMPBIAS /note="Polar residues" uniprot 153 153 ACT_SITE /note="Charge relay system" uniprot 194 194 ACT_SITE /note="Charge relay system" uniprot 368 368 ACT_SITE /note="Charge relay system" uniprot 115 115 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="1" ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD" uniprot 154 154 BINDING /ligand="substrate" ECO:0000305|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD" uniprot 162 162 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="1" ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD" uniprot 174 174 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="2" ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD" uniprot 179 179 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="2" ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD" uniprot 181 181 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="2" ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD" uniprot 191 192 BINDING /ligand="substrate" ECO:0000305|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD" uniprot 205 205 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="1" ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD" uniprot 208 208 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="1" ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD" uniprot 210 210 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="1" ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD" uniprot 212 212 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="1" ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD" uniprot 236 236 BINDING /ligand="substrate" ECO:0000305|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD" uniprot 253 258 BINDING /ligand="substrate" ECO:0000305|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD" uniprot 258 258 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="3" ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD" uniprot 264 264 BINDING /ligand="substrate" ECO:0000305|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD" uniprot 292 295 BINDING /ligand="substrate" ECO:0000305|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD" uniprot 301 301 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="3" ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD" uniprot 306 306 BINDING /ligand="substrate" ECO:0000305|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD" uniprot 308 308 BINDING /ligand="substrate" ECO:0000305|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD" uniprot 331 331 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="3" ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD" uniprot 368 368 BINDING /ligand="substrate" ECO:0000305|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD" disorder 1 22 predicted_by_DISOPRED disorder 78 79 predicted_by_DISOPRED disorder 370 372 predicted_by_DISOPRED disorder 579 591 predicted_by_DISOPRED disorder 676 698 predicted_by_DISOPRED disorder 705 705 predicted_by_DISOPRED disorder 769 794 predicted_by_DISOPRED pdb_monomer 109 574 monomer 4ryd 100.0 C C FURIN_HUMAN 109-574 pdb_monomer 64 89 monomer 6a8y 100.0 A A FURIN_HUMAN 64-89 pdb_complex 109 574 hetero 4omc 100.0 A 1 A FURIN_HUMAN G 1 H 154:191:192:194:227:231-233:236:253-258:264:265:267:292-295:306:308:309:367:368 Furin meta-guanidinomethyl-phenylacetyl-Arg-Val-Arg-(ami.. pdb_complex 109 574 hetero 4ryd 100.0 A 1 A FURIN_HUMAN G 1 H 154:191:192:194:227:231-233:236:253-258:264:265:267:291-295:306:308:309:367:368 Furin para-guanidinomethyl-phenylacetyl-Arg-(3-methylval.. pdb_complex 109 574 hetero 6hlb 100.0 A 1 A FURIN_HUMAN B 1 B 154:191:192:194:227:229:231-233:236:253-258:264:265:292-295:306:308:309:367:368 Furin PHE-(ALN)-ARG-ARG-ARG-ARG-SLL-ARG-00S[7 aa] pdb_complex 110 574 compound 7o1y 100.0 A 1 A FURIN_HUMAN B 1 A UYQ 153:154:191:194:227:253-256:258:306 Furin [[(2E)-2-[[4-[(E)-[[azaniumylidene(azanyl)methyl]h.. pdb_complex 110 574 compound 7o1y 100.0 A 1 A FURIN_HUMAN C 1 A UYQ 227:231:236:255-257:264:265:308 Furin [[(2E)-2-[[4-[(E)-[[azaniumylidene(azanyl)methyl]h.. pdb_complex 110 574 compound 7o1y 100.0 A 1 A FURIN_HUMAN D 1 A UYQ 264:266-268:271 Furin [[(2E)-2-[[4-[(E)-[[azaniumylidene(azanyl)methyl]h.. pdb_complex 110 574 compound 7o1y 100.0 A 1 A FURIN_HUMAN S 1 A NAG 387:443 Furin 2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms].. pdb_complex 110 574 compound 7o20 100.0 A 1 A FURIN_HUMAN B 1 A UYT 231:236:254:255:264:265:308 Furin [azanyl-[(2E)-2-(1-phenylethylidene)hydrazinyl]met.. pdb_complex 110 574 compound 7o20 100.0 A 1 A FURIN_HUMAN C 1 A UYT 227:253-258:306 Furin [azanyl-[(2E)-2-(1-phenylethylidene)hydrazinyl]met.. pdb_complex 110 574 compound 7o20 100.0 A 1 A FURIN_HUMAN D 1 A UYT 266-268:271:272 Furin [azanyl-[(2E)-2-(1-phenylethylidene)hydrazinyl]met.. pdb_complex 111 574 compound 7o22 100.0 A 1 A FURIN_HUMAN M 1 A UYW 194:253-256:258:294:295:306:328:329:365:366:368 Furin [azanyl-[(2E)-2-[[2-[(4-chlorophenyl)methoxy]pheny.. pdb_complex 109 574 metal 4omc 100.0 A 1 A FURIN_HUMAN Q 1 A CA 115:162:205:208:210:212 Furin CALCIUM ION[1 atoms] pdb_complex 109 574 metal 4omc 100.0 A 1 A FURIN_HUMAN R 1 A CA 258:301:331 Furin CALCIUM ION[1 atoms] pdb_complex 109 574 metal 4omc 100.0 A 1 A FURIN_HUMAN S 1 A CA 174:179:181 Furin CALCIUM ION[1 atoms] pdb_complex 109 574 metal 4omc 100.0 A 1 A FURIN_HUMAN T 1 A NA 309:311:314:316:534 Furin SODIUM ION[1 atoms] pdb_complex 109 574 metal 6hlb 100.0 A 1 A FURIN_HUMAN G 1 A NA 279:284 Furin SODIUM ION[1 atoms] pdb_complex 109 574 metal 6hlb 100.0 A 1 A FURIN_HUMAN H 1 A NA 508:544:545 Furin SODIUM ION[1 atoms] pdb_complex 110 574 metal 7o1y 100.0 A 1 A FURIN_HUMAN I 1 A NA 413 Furin SODIUM ION[1 atoms] pdb_complex 109 574 metal 6hlb 100.0 A 1 A FURIN_HUMAN I 1 A CL 313:449:571 Furin CHLORIDE ION[1 atoms] pdb_complex 109 574 precipitant 4omc 100.0 A 1 A FURIN_HUMAN M 1 A FMT 295:328:365:366 Furin FORMIC ACID[3 atoms] pdb_complex 109 574 precipitant 4omc 100.0 A 1 A FURIN_HUMAN N 1 A FMT 263:498:527-529 Furin FORMIC ACID[3 atoms] pdb_complex 109 574 precipitant 4omc 100.0 A 1 A FURIN_HUMAN O 1 A FMT 313:390:447 Furin FORMIC ACID[3 atoms] pdb_complex 109 574 precipitant 6hlb 100.0 A 1 A FURIN_HUMAN J 1 A PO4 118:119:121:125:126 Furin PHOSPHATE ION[5 atoms] pdb_complex 109 574 precipitant 6hlb 100.0 A 1 A FURIN_HUMAN K 1 A PO4 346:347 Furin PHOSPHATE ION[5 atoms] pdb_complex 109 574 precipitant 6hlb 100.0 A 1 A FURIN_HUMAN L 1 A DMS 263:526-529 Furin DIMETHYL SULFOXIDE[4 atoms] pdb_complex 110 574 precipitant 7o1y 100.0 A 1 A FURIN_HUMAN L 1 A DMS 313:390:447 Furin DIMETHYL SULFOXIDE[4 atoms] pdb_complex 110 574 precipitant 7o1y 100.0 A 1 A FURIN_HUMAN M 1 A DMS 186:357 Furin DIMETHYL SULFOXIDE[4 atoms] pdb_complex 110 574 precipitant 7o1y 100.0 A 1 A FURIN_HUMAN N 1 A DMS 295:328:329:365:366 Furin DIMETHYL SULFOXIDE[4 atoms] pdb_complex 110 574 precipitant 7o1y 100.0 A 1 A FURIN_HUMAN O 1 A DMS 177:183:225 Furin DIMETHYL SULFOXIDE[4 atoms] pdb_complex 110 574 precipitant 7o1y 100.0 A 1 A FURIN_HUMAN P 1 A DMS 326:408:409:423 Furin DIMETHYL SULFOXIDE[4 atoms] pdb_complex 110 574 precipitant 7o1y 100.0 A 1 A FURIN_HUMAN Q 1 A DMS 194:368 Furin DIMETHYL SULFOXIDE[4 atoms]