type start end name pdb_id identity asym_id_homo oper_homo auth_asym_id_homo mol_id_homo asym_id_con oper_con auth_asym_id_con mol_id_con sites description_homo description_con
length 1 1170
id 1 1170 ITAL_HUMAN
title 1 1170 RecName: Full=Integrin alpha-L ;AltName: Full=CD11 antigen-like family member A;AltName: Full=Leukocyte adhesion glycoprotein LFA-1 alpha chain; Short=LFA-1A;AltName: Full=Leukocyte function-associated molecule 1 alpha chain;AltName: CD_antigen=CD11a;Flags: Precursor;
seq 1 1170 MKDSCITVMAMALLSGFFFFAPASSYNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGAPGEGNSTGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTDGSILACDPGLSRTCDQNTYLSGLCYLFRQNLQGPMLQGRPGFQECIKGNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKRKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKFASKPASEFVKILDTFEKLKDLFTELQKKIYVIEGTSKQDLTSFNMELSSSGISADLSRGHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNEPLTPEVRAGYLGYTVTWLPSRQKTSLLASGAPRYQHMGRVLLFQEPQGGGHWSQVQTIHGTQIGSYFGGELCGVDVDQDGETELLLIGAPLFYGEQRGGRVFIYQRRQLGFEEVSELQGDPGYPLGRFGEAITALTDINGDGLVDVAVGAPLEEQGAVYIFNGRHGGLSPQPSQRIEGTQVLSGIQWFGRSIHGVKDLEGDGLADVAVGAESQMIVLSSRPVVDMVTLMSFSPAEIPVHEVECSYSTSNKMKEGVNITICFQIKSLIPQFQGRLVANLTYTLQLDGHRTRRRGLFPGGRHELRRNIAVTTSMSCTDFSFHFPVCVQDLISPINVSLNFSLWEEEGTPRDQRAQGKDIPPILRPSLHSETWEIPFEKNCGEDKKCEANLRVSFSPARSRALRLTAFASLSVELSLSNLEEDAYWVQLDLHFPPGLSFRKVEMLKPHSQIPVSCEELPEESRLLSRALSCNVSSPIFKAGHSVALQMMFNTLVNSSWGDSVELHANVTCNNEDSDLLEDNSATTIIPILYPINILIQDQEDSTLYVSFTPKGPKIHQVKHMYQVRIQPSIHDHNIPTLEAVVGVPQPPSEGPITHQWSVQMEPPVPCHYEDLERLPDAAEPCLPGALFRCPVVFRQEILVQVIGTLELVGEIEASSMFSLCSSLSISFNSSKHFHLYGSNASLAQVVMKVDVVYEKQMLYLYVLSGIGGLLLLLLIFIVLYKVGFFKRNLKEKMEAGRGVPNGIPAEDSEQLASGQEAGDPGCLKPLHEKDSESGGGKD
uniprot 1 25 SIGNAL
uniprot 26 1170 CHAIN /note="Integrin alpha-L" /id="PRO_0000016292"
uniprot 26 1090 TOPO_DOM /note="Extracellular"
uniprot 1091 1111 TRANSMEM /note="Helical"
uniprot 1112 1170 TOPO_DOM /note="Cytoplasmic"
uniprot 156 327 DOMAIN /note="VWFA"
uniprot 1128 1170 REGION /note="Disordered"
uniprot 1154 1170 COMPBIAS /note="Basic and acidic residues"
uniprot 468 468 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="1"
uniprot 470 470 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="1"
uniprot 472 472 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="1"
uniprot 476 476 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="1"
uniprot 530 530 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="2"
uniprot 532 532 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="2"
uniprot 534 534 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="2"
uniprot 538 538 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="2"
uniprot 590 590 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="3"
uniprot 594 594 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="3"
uniprot 598 598 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="3"
disorder 1 23 predicted_by_DISOPRED
disorder 738 746 predicted_by_DISOPRED
disorder 841 849 predicted_by_DISOPRED
disorder 988 988 predicted_by_DISOPRED
disorder 990 990 predicted_by_DISOPRED
disorder 992 1014 predicted_by_DISOPRED
disorder 1125 1170 predicted_by_DISOPRED
pdb_monomer 153 336 monomer 1rd4 100.0 C C ITAL_HUMAN 153-336
pdb_monomer 1082 1128 monomer 2m3e 100.0 A A ITAL_HUMAN 1082-1128
pdb_complex 153 331 hetero 3eoa 100.0 E 1 I ITAL_HUMAN A 1 L 169 Integrin alpha-L Efalizumab Fab fragment, light chain[214 aa]
pdb_complex 153 331 hetero 3eoa 100.0 E 1 I ITAL_HUMAN C 1 H 169:172:173:176:180:216:218:219:222-226:228 Integrin alpha-L Efalizumab Fab fragment, heavy chain[215 aa]
pdb_complex 153 336 compound 1rd4 100.0 A 1 A ITAL_HUMAN E 1 A L08 157:159:178:182:191:258:260:280:282-284:309-312:323:326:327:330 Integrin alpha-L 1-ACETYL-4-(4-{4-[(2-ETHOXYPHENYL)THIO]-3-NITROPHE..
pdb_complex 154 331 compound 2ica 100.0 A 1 A ITAL_HUMAN B 1 A 2IC 159:182:186:191:258:260:280:282:284:312:327:331 Integrin alpha-L 5-[(5S,9R)-9-(4-CYANOPHENYL)-3-(3,5-DICHLOROPHENYL..
pdb_complex 154 332 compound 2o7n 100.0 A 1 A ITAL_HUMAN B 1 A 2O7 157:159:182:191:258:260:282:312:327:328:330:331 Integrin alpha-L 7A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-..
pdb_complex 154 332 compound 3m6f 100.0 A 1 A ITAL_HUMAN B 1 A BJZ 155:159:182:186:191:256:258:260:280:282:284:312:327:330:331 Integrin alpha-L 6-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl..
pdb_complex 153 334 compound 7kc5 100.0 A 1 A ITAL_HUMAN D 1 A BJZ 182:191:256:260:280:282:284:309:312:324:327:331 Integrin alpha-L 6-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl..
pdb_complex 153 334 compound 7kc6 100.0 A 1 C ITAL_HUMAN C 1 C 803 157:258:260:282:309:312:323:326:327 Integrin alpha-L LOVASTATIN[29 atoms]
pdb_complex 153 335 metal 1lfa 100.0 A 1 A ITAL_HUMAN C 1 A MN 164:166:264 CD11A MANGANESE (II) ION[1 atoms]
pdb_complex 153 335 metal 1lfa 100.0 A 1 A ITAL_HUMAN D 1 A CL 164-166 CD11A CHLORIDE ION[1 atoms]
pdb_complex 153 335 metal 1zoo 100.0 A 1 A ITAL_HUMAN C 1 A MG 162:164:166:231:264 LEUKOCYTE ADHESION GLYCOPROTEIN MAGNESIUM ION[1 atoms]
pdb_complex 153 334 metal 7kc5 100.0 A 1 A ITAL_HUMAN C 1 A MG 162:164:165:230:231:264 Integrin alpha-L MAGNESIUM ION[1 atoms]
pdb_complex 153 331 metal 3eob 100.0 C 1 I ITAL_HUMAN G 1 I ZN 162:164:166:231:264:265 Integrin alpha-L ZINC ION[1 atoms]
pdb_complex 153 335 homo 1lfa 100.0 A 1 A ITAL_HUMAN B 1 B ITAL_HUMAN 168:169:225:226:228 CD11A CD11A[182 aa]
pdb_complex 153 334 homo 1lfa 100.0 B 1 B ITAL_HUMAN A 1 A ITAL_HUMAN 169:170:173:177:180:218:222 CD11A CD11A[183 aa]
pdb_complex 153 335 homo 1zoo 100.0 A 1 A ITAL_HUMAN B 1 B ITAL_HUMAN 153:184-191:309:310:327-335 LEUKOCYTE ADHESION GLYCOPROTEIN LEUKOCYTE ADHESION GLYCOPROTEIN[183 aa]
pdb_complex 154 332 precipitant 3m6f 100.0 A 1 A ITAL_HUMAN C 1 A NO3 300:301:305 Integrin alpha-L NITRATE ION[4 atoms]