type start end name pdb_id identity asym_id_homo oper_homo auth_asym_id_homo mol_id_homo asym_id_con oper_con auth_asym_id_con mol_id_con sites description_homo description_con length 1 425 id 1 425 SMAD3_HUMAN title 1 425 RecName: Full=Mothers against decapentaplegic homolog 3; Short=MAD homolog 3; Short=Mad3; Short=Mothers against DPP homolog 3; Short=hMAD-3;AltName: Full=JV15-2;AltName: Full=SMAD family member 3; Short=SMAD 3; Short=Smad3; Short=hSMAD3; seq 1 425 MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS uniprot 2 425 CHAIN /note="Mothers against decapentaplegic homolog 3" /id="PRO_0000090856" uniprot 10 136 DOMAIN /note="MH1" uniprot 232 425 DOMAIN /note="MH2" uniprot 137 231 REGION /note="Linker" uniprot 165 208 REGION /note="Disordered" uniprot 271 324 REGION /note="Sufficient for interaction with XPO4" uniprot 64 64 BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" uniprot 109 109 BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" uniprot 121 121 BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" uniprot 126 126 BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" disorder 1 9 predicted_by_DISOPRED disorder 172 212 predicted_by_DISOPRED disorder 215 215 predicted_by_DISOPRED disorder 418 425 predicted_by_DISOPRED pdb_monomer 220 416 monomer 1mk2 100.0 A A SMAD3_HUMAN 220-416 pdb_monomer 7 132 monomer 1ozj 100.0 C A SMAD3_HUMAN 7-132 pdb_complex 220 416 hetero 1mk2 100.0 A 1 A SMAD3_HUMAN B 1 B ZFYV9_HUMAN 220-226:297:299:300:304:324:326:332:333:335:337-340:345:349:352:353:356:383:406:410:413:414:416 SMAD 3 Madh-interacting protein[38 aa] pdb_complex 228 424 hetero 1u7f 100.0 A 1 A SMAD3_HUMAN B 1 B SMAD4_HUMAN 238:241:243:246:247:360:364:367:390:395:397:399:401:404:405:407:408:411:412:416:417:419-424 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 4[193 aa] pdb_complex 230 424 hetero 1u7f 100.0 C 1 C SMAD3_HUMAN B 1 B SMAD4_HUMAN 246:259-265:268:272:273:275-279:284:287:288:310 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 4[193 aa] pdb_complex 221 414 hetero 5xoc 100.0 A 1 A SMAD3_HUMAN B 1 B THIO_ECOLI:FOXH1_HUMAN 316:324:326-333:335:338-340:351:355:358:362:365:368:380-384:387 Mothers against decapentaplegic homolog 3 Thioredoxin 1,Forkhead box protein H1[133 aa] pdb_complex 10 132 nucleotide 1mhd 100.0 C 1 A SMAD3_HUMAN A 1 C 33:37:70:71:75-78:81 SMAD3 DNA pdb_complex 10 132 nucleotide 1mhd 100.0 C 1 A SMAD3_HUMAN B 1 D 74:81:100:101 SMAD3 DNA pdb_complex 10 132 nucleotide 1mhd 100.0 D 1 B SMAD3_HUMAN B 1 D 37:70:71:75:76:78:81 SMAD3 DNA pdb_complex 7 132 nucleotide 1ozj 100.0 C 1 A SMAD3_HUMAN A 1 C 33:37:70:71:74-78:81 SMAD 3 Smad binding element pdb_complex 7 132 nucleotide 1ozj 100.0 C 1 A SMAD3_HUMAN B 1 D 40:74:76:81:100:101 SMAD 3 Smad binding element pdb_complex 11 134 nucleotide 5od6 100.0 A 1 A SMAD3_HUMAN C 1 C 40:74:81:100:101 Mothers against decapentaplegic homolog 3 DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*GP*CP*GP*CP*CP*TP.. pdb_complex 11 134 nucleotide 5od6 100.0 A 1 A SMAD3_HUMAN D 1 D 70:71:74-79:81 Mothers against decapentaplegic homolog 3 DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*GP*CP*GP*CP*CP*TP.. pdb_complex 11 135 nucleotide 5odg 100.0 A 1 A SMAD3_HUMAN C 1 D 70:71:74-78:81 Mothers against decapentaplegic homolog 3 DNA (5'-D(P*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP.. pdb_complex 11 135 nucleotide 5odg 100.0 A 1 A SMAD3_HUMAN D 1 E 74:76:81:100:101 Mothers against decapentaplegic homolog 3 DNA (5'-D(P*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP.. pdb_complex 7 132 metal 1ozj 100.0 C 1 A SMAD3_HUMAN E 1 A ZN 64:109:121:126 SMAD 3 ZINC ION[1 atoms] pdb_complex 11 134 metal 5od6 100.0 A 1 A SMAD3_HUMAN E 1 A ZN 64:109:121:126 Mothers against decapentaplegic homolog 3 ZINC ION[1 atoms] pdb_complex 11 135 metal 5odg 100.0 A 1 A SMAD3_HUMAN F 1 A CL 64 Mothers against decapentaplegic homolog 3 CHLORIDE ION[1 atoms] pdb_complex 220 416 homo 1mk2 100.0 A 1 A SMAD3_HUMAN A 2 A SMAD3_HUMAN 316:325-329:361:364:380-382:387 SMAD 3 SMAD 3[197 aa] pdb_complex 228 424 homo 1u7f 100.0 A 1 A SMAD3_HUMAN C 1 C SMAD3_HUMAN 246:260-264:268:273:275:277:278:287-289:310:311:333:377-379:384-386 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 3[196 aa] pdb_complex 230 424 homo 1u7f 100.0 C 1 C SMAD3_HUMAN A 1 A SMAD3_HUMAN 238:241:247:249:361:364:367:390:395:397:399:401:404:405:408:411:417:419-424 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 3[198 aa] pdb_complex 221 414 homo 5xoc 100.0 A 1 A SMAD3_HUMAN A 2 A SMAD3_HUMAN 229:238:241:247:249:364:367:390:395:397:399:401:404:407:408:411:412 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 3[194 aa] pdb_complex 221 414 homo 5xoc 100.0 A 1 A SMAD3_HUMAN A 3 A SMAD3_HUMAN 246:259-264:268:272:273:275:277:278:288 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 3[194 aa] pdb_complex 7 132 homo 1ozj 100.0 C 1 A SMAD3_HUMAN D 1 B SMAD3_HUMAN 79 SMAD 3 SMAD 3[124 aa] pdb_complex 11 134 homo 5od6 100.0 A 1 A SMAD3_HUMAN B 1 B SMAD3_HUMAN 129-132:134 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 3[126 aa] pdb_complex 220 416 precipitant 1mk2 100.0 A 1 A SMAD3_HUMAN C 1 A ACY 318:321:327-329:368 SMAD 3 ACETIC ACID[4 atoms] pdb_complex 220 416 precipitant 1mk2 100.0 A 1 A SMAD3_HUMAN D 1 A ACY 316:373:380:387-389 SMAD 3 ACETIC ACID[4 atoms] pdb_complex 220 416 precipitant 1mk2 100.0 A 1 A SMAD3_HUMAN E 1 A ACY 383-385 SMAD 3 ACETIC ACID[4 atoms] pdb_complex 220 416 precipitant 1mk2 100.0 A 1 A SMAD3_HUMAN F 1 A ACY 248:249:265:266 SMAD 3 ACETIC ACID[4 atoms]