type start end name pdb_id identity asym_id_homo oper_homo auth_asym_id_homo mol_id_homo asym_id_con oper_con auth_asym_id_con mol_id_con sites description_homo description_con length 1 427 id 1 427 IRF3_HUMAN title 1 427 RecName: Full=Interferon regulatory factor 3 ; Short=IRF-3 ; seq 1 427 MGTPKPRILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQDAQQEDFGIFQAWAEATGAYVPGRDKPDLPTWKRNFRSALNRKEGLRLAEDRSKDPHDPHKIYEFVNSGVGDFSQPDTSPDTNGGGSTSDTQEDILDELLGNMVLAPLPDPGPPSLAVAPEPCPQPLRSPSLDNPTPFPNLGPSENPLKRLLVPGEEWEFEVTAFYRGRQVFQQTISCPEGLRLVGSEVGDRTLPGWPVTLPDPGMSLTDRGVMSYVRHVLSCLGGGLALWRAGQWLWAQRLGHCHTYWAVSEELLPNSGHGPDGEVPKDKEGGVFDLGPFIVDLITFTEGSGRSPRYALWFCVGESWPQDQPWTKRLVMVKVVPTCLRALVEMARVGGASSLENTVDLHISNSHPLSLTSDQYKAYLQDLVEGMDFQGPGES uniprot 1 427 CHAIN /note="Interferon regulatory factor 3" /id="PRO_0000154553" uniprot 5 111 DNA_BIND /note="IRF tryptophan pentad repeat" uniprot 91 136 REGION /note="Disordered" uniprot 141 427 REGION /note="Mediates interaction with ZDHHC11" uniprot 200 360 REGION /note="Interaction with HERC5" uniprot 91 106 COMPBIAS /note="Basic and acidic residues" uniprot 115 136 COMPBIAS /note="Polar residues" disorder 1 4 predicted_by_DISOPRED disorder 116 146 predicted_by_DISOPRED disorder 150 188 predicted_by_DISOPRED disorder 423 427 predicted_by_DISOPRED pdb_monomer 189 427 monomer 1qwt 100.0 B B IRF3_HUMAN 189-427 pdb_monomer 1 112 monomer 2pi0 100.0 D B IRF3_HUMAN 1-112 pdb_complex 196 386 hetero 1zoq 100.0 A 1 A IRF3_HUMAN B 1 C CBP_HUMAN 201-203:221:326:329:330:333:370-372:374:375:378:379:381-383 Interferon regulatory factor 3 CREB-binding protein[47 aa] pdb_complex 196 398 hetero 5jem 99.0 A 1 A IRF3_HUMAN B 1 C CBP_HUMAN 201-203:221:326:329:330:333:370:371:374:375:377-379:382-384 Interferon regulatory factor 3 CREB-binding protein[42 aa] pdb_complex 196 398 hetero 5jem 99.0 A 1 A IRF3_HUMAN D 1 D CBP_HUMAN 249-251 Interferon regulatory factor 3 CREB-binding protein[42 aa] pdb_complex 200 396 hetero 7jfm 75.3 A 1 A IRF3_MOUSE D 1 D CBP_HUMAN 253 Interferon regulatory factor 3 CREB-binding protein[37 aa] pdb_complex 201 398 hetero 7jfm 75.6 C 1 B IRF3_MOUSE D 1 D CBP_HUMAN 201-203:221:326:329:330:333:370:371:374:375:377-379:382:384 Interferon regulatory factor 3 CREB-binding protein[37 aa] pdb_complex 3 112 hetero 1t2k 100.0 C 1 A IRF3_HUMAN F 1 D ATF2_HUMAN 43-45 Interferon regulatory factor 3 Cyclic-AMP-dependent transcription factor ATF-2[61.. pdb_complex 189 422 hetero 5jej 100.0 D 1 A IRF3_HUMAN B 1 D STING_HUMAN 260:263:264:267:285:288-290:292:313:349-351:360:362 Interferon regulatory factor 3 Stimulator of interferon genes protein[10 aa] pdb_complex 189 422 hetero 5jej 100.0 D 1 A IRF3_HUMAN C 1 E STING_HUMAN 337:338 Interferon regulatory factor 3 Stimulator of interferon genes protein[4 aa] pdb_complex 189 421 hetero 5jej 100.0 E 1 B IRF3_HUMAN C 1 E STING_HUMAN 211:256:257:260:360 Interferon regulatory factor 3 Stimulator of interferon genes protein[4 aa] pdb_complex 189 421 hetero 5jej 100.0 E 1 B IRF3_HUMAN A 1 C STING_HUMAN 260:263:264:267:285:287-290:292:313:349-351:362 Interferon regulatory factor 3 Stimulator of interferon genes protein[21 aa] pdb_complex 189 422 hetero 5jek 100.0 A 1 A IRF3_HUMAN C 1 C 259:260:263:267:285:287-290:313:349:350:362 Interferon regulatory factor 3 MAVS peptide[14 aa] pdb_complex 189 422 hetero 5jek 100.0 B 1 B IRF3_HUMAN D 1 D 259:260:263:264:267:285:287-290:313:349 Interferon regulatory factor 3 MAVS peptide[16 aa] pdb_complex 189 422 hetero 5jel 100.0 A 1 A IRF3_HUMAN B 1 B 211:260:263:264:267:285:288-290:292:313:349-351:356:361 Interferon regulatory factor 3 Phosphorylated TRIF peptide[14 aa] pdb_complex 189 422 hetero 5jeo 100.0 B 1 A IRF3_HUMAN A 1 B 211:257:260:263:267:285:287-290:292:313:349-351:360:362 Interferon regulatory factor 3 Rotavirus NSP1 peptide[10 aa] pdb_complex 189 422 hetero 5jer 100.0 E 1 A IRF3_HUMAN A 1 B 211:257:260:263:264:267:288:290:292:349-351:360:362 Interferon regulatory factor 3 Rotavirus NSP1 peptide[10 aa] pdb_complex 189 422 hetero 5jer 100.0 F 1 C IRF3_HUMAN D 1 H 338 Interferon regulatory factor 3 Rotavirus NSP1 peptide[10 aa] pdb_complex 3 112 nucleotide 1t2k 100.0 C 1 A IRF3_HUMAN A 1 E 38:40-42:74:77:81:86:105 Interferon regulatory factor 3 31-MER pdb_complex 3 112 nucleotide 1t2k 100.0 C 1 A IRF3_HUMAN B 1 F 5-8:40:42-44:57:61:78:79:82:83:86:87:98 Interferon regulatory factor 3 31-MER pdb_complex 9 111 nucleotide 2o61 100.0 C 1 A TF65_HUMAN:IRF7_HUMAN:IRF3_HUMAN A 1 E 38-42:74:77:78:81:86:105 Transcription factor p65/Interferon regulatory fac.. 36-MER pdb_complex 9 111 nucleotide 2o61 100.0 C 1 A TF65_HUMAN:IRF7_HUMAN:IRF3_HUMAN B 1 F 40:42-44:57:61:75:78:79:82:86:87:98 Transcription factor p65/Interferon regulatory fac.. 34-MER pdb_complex 3 112 nucleotide 2o6g 100.0 C 1 E IRF3_HUMAN A 1 D 38:40-42:74:77:78:81:82:86:95:105 Interferon regulatory factor 3 interferon-b enhancer pdb_complex 3 112 nucleotide 2o6g 100.0 C 1 E IRF3_HUMAN B 1 C 5-8:40:42-44:57:61:78:79:82:86:87:98 Interferon regulatory factor 3 interferon-b enhancer pdb_complex 5 110 nucleotide 2pi0 100.0 C 1 A IRF3_HUMAN A 1 E 38-42:74:77:78:81:85:86:105 Interferon regulatory factor 3 PRDIII-I region of human interferon-B promoter str.. pdb_complex 5 110 nucleotide 2pi0 100.0 C 1 A IRF3_HUMAN B 1 F 5-8:40:42:57:61:79:82:83:86:87 Interferon regulatory factor 3 PRDIII-I region of human interferon-B promoter str.. pdb_complex 5 110 metal 3qu6 99.0 A 1 A Q7Z5G6_HUMAN D 1 A ZN 55:59 IRF3 protein ZINC ION[1 atoms] pdb_complex 5 110 metal 3qu6 99.0 A 1 A Q7Z5G6_HUMAN E 1 A ZN 13:17 IRF3 protein ZINC ION[1 atoms] pdb_complex 5 110 metal 3qu6 99.0 A 1 A Q7Z5G6_HUMAN F 1 A ZN 99:101 IRF3 protein ZINC ION[1 atoms] pdb_complex 5 110 metal 3qu6 99.0 A 1 A Q7Z5G6_HUMAN G 1 A ZN 94:96:104:106 IRF3 protein ZINC ION[1 atoms] pdb_complex 5 110 metal 3qu6 99.0 A 1 A Q7Z5G6_HUMAN H 1 A CL 96:99:102:104 IRF3 protein CHLORIDE ION[1 atoms] pdb_complex 5 110 metal 3qu6 99.0 A 1 A Q7Z5G6_HUMAN I 1 A CL 17 IRF3 protein CHLORIDE ION[1 atoms] pdb_complex 5 110 metal 3qu6 99.0 A 1 A Q7Z5G6_HUMAN M 1 A CL 51:55:56:59 IRF3 protein CHLORIDE ION[1 atoms] pdb_complex 5 110 metal 3qu6 99.0 A 1 A Q7Z5G6_HUMAN K 1 A NA 23:25 IRF3 protein SODIUM ION[1 atoms] pdb_complex 5 110 metal 3qu6 99.0 A 1 A Q7Z5G6_HUMAN L 1 A NA 50:52:54:55:73 IRF3 protein SODIUM ION[1 atoms] pdb_complex 200 396 homo 7jfm 75.3 A 1 A IRF3_MOUSE C 1 B IRF3_MOUSE 209:211-213:253-257:260:263:264:285:288-290:297:299:300:313:349-351:358:359:362:377:380:381:384-387:391:393-396 Interferon regulatory factor 3 Interferon regulatory factor 3[194 aa] pdb_complex 189 427 homo 1qwt 100.0 A 1 A IRF3_HUMAN B 1 B IRF3_HUMAN 214:217:381:384-389 Interferon regulatory factor 3 Interferon regulatory factor 3[239 aa] pdb_complex 189 427 homo 1qwt 100.0 B 1 B IRF3_HUMAN A 1 A IRF3_HUMAN 209:212:214:299-302:345:383:384 Interferon regulatory factor 3 Interferon regulatory factor 3[239 aa] pdb_complex 189 422 homo 5jej 100.0 D 1 A IRF3_HUMAN E 1 B IRF3_HUMAN 209:212:250-253:297:299:300:303:332:333:335:357-359:379:380:383:384 Interferon regulatory factor 3 Interferon regulatory factor 3[233 aa] pdb_complex 3 112 homo 2o6g 100.0 C 1 E IRF3_HUMAN E 1 G IRF3_HUMAN 7:10:88 Interferon regulatory factor 3 Interferon regulatory factor 3[110 aa] pdb_complex 3 112 homo 2o6g 100.0 E 1 G IRF3_HUMAN C 1 E IRF3_HUMAN 42:44:101 Interferon regulatory factor 3 Interferon regulatory factor 3[110 aa] pdb_complex 4 110 homo 2pi0 100.0 E 1 C IRF3_HUMAN C 1 A IRF3_HUMAN 44 Interferon regulatory factor 3 Interferon regulatory factor 3[98 aa] pdb_complex 189 427 precipitant 1qwt 100.0 A 1 A IRF3_HUMAN C 1 A PO4 266:267:269:288 Interferon regulatory factor 3 PHOSPHATE ION[5 atoms] pdb_complex 189 427 precipitant 1qwt 100.0 A 1 A IRF3_HUMAN D 1 A PO4 200-202:204:222:276 Interferon regulatory factor 3 PHOSPHATE ION[5 atoms] pdb_complex 189 427 precipitant 1qwt 100.0 A 1 A IRF3_HUMAN E 1 A PO4 224:239:275 Interferon regulatory factor 3 PHOSPHATE ION[5 atoms] pdb_complex 189 427 precipitant 1qwt 100.0 B 1 B IRF3_HUMAN I 1 B PO4 194:399-401 Interferon regulatory factor 3 PHOSPHATE ION[5 atoms] pdb_complex 189 427 precipitant 1qwt 100.0 B 1 B IRF3_HUMAN J 1 B PO4 259:260:263:350 Interferon regulatory factor 3 PHOSPHATE ION[5 atoms] pdb_complex 189 422 precipitant 5jeo 100.0 B 1 A IRF3_HUMAN C 1 A PO4 328:338:340:341 Interferon regulatory factor 3 PHOSPHATE ION[5 atoms] pdb_complex 189 422 precipitant 5jeo 100.0 B 1 A IRF3_HUMAN D 2 A PO4 211:254:257 Interferon regulatory factor 3 PHOSPHATE ION[5 atoms] pdb_complex 189 422 precipitant 5jeo 100.0 B 1 A IRF3_HUMAN E 1 A PO4 335:337 Interferon regulatory factor 3 PHOSPHATE ION[5 atoms] pdb_complex 189 427 precipitant 3a77 100.0 A 1 A IRF3_HUMAN E 1 A ACY 292:307:356-358 Interferon regulatory factor 3 ACETIC ACID[4 atoms] pdb_complex 189 427 precipitant 3a77 100.0 A 1 A IRF3_HUMAN F 1 A MPD 224:239:273:275:284 Interferon regulatory factor 3 (4S)-2-METHYL-2,4-PENTANEDIOL[8 atoms]