type start end name pdb_id identity asym_id_homo oper_homo auth_asym_id_homo mol_id_homo asym_id_con oper_con auth_asym_id_con mol_id_con sites description_homo description_con length 1 631 id 1 631 ASM_HUMAN title 1 631 RecName: Full=Sphingomyelin phosphodiesterase ; EC=3.1.4.12 ; EC=3.1.4.3 ;AltName: Full=Acid sphingomyelinase ; Short=aSMase;Contains: RecName: Full=Sphingomyelin phosphodiesterase, processed form ;Flags: Precursor; seq 1 631 MPRYGASLRQSCPRSGREQGQDGTAGAPGLLWMGLVLALALALALALALSDSRVLWAPAEAHPLSPQGHPARLHRIVPRLRDVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMVEVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLMPDGSLPEAQSLWPRPLFC uniprot 1 46 SIGNAL uniprot 47 631 CHAIN /note="Sphingomyelin phosphodiesterase" /id="PRO_0000002323" uniprot 254 631 CHAIN /note="Sphingomyelin phosphodiesterase, processed form" /id="PRO_0000456684" uniprot 87 171 DOMAIN /note="Saposin B-type" uniprot 1 23 REGION /note="Disordered" uniprot 208 208 BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" uniprot 210 210 BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" uniprot 280 280 BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" uniprot 280 280 BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" uniprot 320 320 BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" uniprot 427 427 BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" uniprot 459 459 BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" uniprot 461 461 BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" ECO:0007744|PDB:5I81, ECO:0007744|PDB:5I85, ECO:0007744|PDB:5I8R, ECO:0007744|PDB:5JG8" disorder 1 25 predicted_by_DISOPRED disorder 184 196 predicted_by_DISOPRED pdb_monomer 84 613 monomer 5jg8 100.0 B B ASM_HUMAN 84-613 pdb_complex 86 613 compound 5i81 100.0 A 1 A ASM_HUMAN E 1 A NAG 88 Sphingomyelin phosphodiesterase 2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms].. pdb_complex 86 613 compound 5i81 100.0 A 1 A ASM_HUMAN E 2 A NAG 126:127 Sphingomyelin phosphodiesterase 2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms].. pdb_complex 86 613 compound 5i81 100.0 A 1 A ASM_HUMAN F 1 A NAG 175-177 Sphingomyelin phosphodiesterase 2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms].. pdb_complex 86 613 compound 5i81 100.0 A 1 A ASM_HUMAN H 1 A NAG 374:505 Sphingomyelin phosphodiesterase 2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms].. pdb_complex 86 613 compound 5i81 100.0 A 1 A ASM_HUMAN J 1 A NAG 522:524:525:536:574:579 Sphingomyelin phosphodiesterase 2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms].. pdb_complex 86 613 compound 5i8r 100.0 C 1 C ASM_HUMAN BA 1 C NAG 397 Sphingomyelin phosphodiesterase 2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms].. pdb_complex 85 613 compound 5jg8 100.0 A 1 A ASM_HUMAN N 1 A NAG 175-177:435:436 Sphingomyelin phosphodiesterase 2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms].. pdb_complex 85 613 compound 5jg8 100.0 A 1 A ASM_HUMAN O 1 A NAG 171:397 Sphingomyelin phosphodiesterase 2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms].. pdb_complex 85 613 compound 5jg8 100.0 A 1 A ASM_HUMAN S 1 B NAG 127 Sphingomyelin phosphodiesterase 2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms].. pdb_complex 86 613 compound 5i85 100.0 A 1 A ASM_HUMAN U 1 A PC 208:210:280:284:320:321:427:459:461 Sphingomyelin phosphodiesterase PHOSPHOCHOLINE[11 atoms] pdb_complex 86 613 metal 5i81 100.0 A 1 A ASM_HUMAN L 1 A ZN 208:280:320:427:459 Sphingomyelin phosphodiesterase ZINC ION[1 atoms] pdb_complex 85 613 metal 5jg8 100.0 A 1 A ASM_HUMAN J 1 A ZN 208:210:280:461 Sphingomyelin phosphodiesterase ZINC ION[1 atoms] pdb_complex 86 613 otherpoly 5i81 100.0 A 1 A ASM_HUMAN B 1 B 139:289-291:337 Sphingomyelin phosphodiesterase 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. pdb_complex 86 613 otherpoly 5i85 100.0 A 1 A ASM_HUMAN D 1 D 520:522:524:525:536:574:579 Sphingomyelin phosphodiesterase 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. pdb_complex 86 613 otherpoly 5i8r 100.0 A 1 A ASM_HUMAN E 1 E 171:397 Sphingomyelin phosphodiesterase 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. pdb_complex 85 613 otherpoly 5jg8 100.0 A 1 A ASM_HUMAN C 1 C 522:524:525:536:574 Sphingomyelin phosphodiesterase 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. pdb_complex 85 613 otherpoly 5jg8 100.0 A 1 A ASM_HUMAN D 1 D 373:374:505 Sphingomyelin phosphodiesterase 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. pdb_complex 84 613 otherpoly 5jg8 100.0 B 1 B ASM_HUMAN H 1 H 171:397 Sphingomyelin phosphodiesterase 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. pdb_complex 86 613 otherpoly 5i81 100.0 A 1 A ASM_HUMAN C 1 C 171:397:399 Sphingomyelin phosphodiesterase beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet.. pdb_complex 86 613 otherpoly 5i85 100.0 A 1 A ASM_HUMAN B 1 B 290:291:337 Sphingomyelin phosphodiesterase beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet.. pdb_complex 86 613 otherpoly 5i8r 100.0 B 1 B ASM_HUMAN H 1 H 522:525:536:574 Sphingomyelin phosphodiesterase beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet.. pdb_complex 86 613 otherpoly 5i81 100.0 A 1 A ASM_HUMAN D 1 D 177-179 Sphingomyelin phosphodiesterase beta-D-mannopyranose-(1-3)-alpha-D-mannopyranose pdb_complex 86 613 otherpoly 5i85 100.0 A 1 A ASM_HUMAN C 1 C 171:177-179:397:399:406 Sphingomyelin phosphodiesterase alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-.. pdb_complex 85 613 otherpoly 5jg8 100.0 A 1 A ASM_HUMAN E 1 E 290:291:337:338 Sphingomyelin phosphodiesterase 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-a.. pdb_complex 84 613 otherpoly 5jg8 100.0 B 1 B ASM_HUMAN F 1 F 522:524:525:536:574:579 Sphingomyelin phosphodiesterase alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-be.. pdb_complex 84 613 otherpoly 5jg8 100.0 B 1 B ASM_HUMAN G 1 G 139:289-291:337 Sphingomyelin phosphodiesterase alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-be.. pdb_complex 86 613 homo 5i81 100.0 A 1 A ASM_HUMAN A 2 A ASM_HUMAN 86:88:89:92:93:95-101:105:114:117:118:121:122:127:136:137:148:152:153:162:226:286:327 Sphingomyelin phosphodiesterase Sphingomyelin phosphodiesterase[528 aa] pdb_complex 86 613 homo 5i85 100.0 A 1 A ASM_HUMAN A 3 A ASM_HUMAN 264:267:268:270:271:307:308:311:312 Sphingomyelin phosphodiesterase Sphingomyelin phosphodiesterase[528 aa] pdb_complex 86 613 homo 5i85 100.0 A 1 A ASM_HUMAN A 4 A ASM_HUMAN 236-239:249:528:529:580-583 Sphingomyelin phosphodiesterase Sphingomyelin phosphodiesterase[528 aa] pdb_complex 86 613 precipitant 5i81 100.0 A 1 A ASM_HUMAN N 1 A SO4 432:459 Sphingomyelin phosphodiesterase SULFATE ION[5 atoms] pdb_complex 86 613 precipitant 5i81 100.0 A 1 A ASM_HUMAN O 1 A SO4 107:110 Sphingomyelin phosphodiesterase SULFATE ION[5 atoms] pdb_complex 86 613 precipitant 5i81 100.0 A 1 A ASM_HUMAN P 1 A SO4 134:135:138 Sphingomyelin phosphodiesterase SULFATE ION[5 atoms] pdb_complex 86 613 precipitant 5i81 100.0 A 1 A ASM_HUMAN Q 1 A SO4 189:192 Sphingomyelin phosphodiesterase SULFATE ION[5 atoms] pdb_complex 86 613 precipitant 5i81 100.0 A 1 A ASM_HUMAN R 1 A SO4 150:333-335:338 Sphingomyelin phosphodiesterase SULFATE ION[5 atoms] pdb_complex 86 613 precipitant 5i81 100.0 A 1 A ASM_HUMAN S 1 A SO4 174:175 Sphingomyelin phosphodiesterase SULFATE ION[5 atoms] pdb_complex 86 613 precipitant 5i81 100.0 A 1 A ASM_HUMAN T 1 A SO4 585-590 Sphingomyelin phosphodiesterase SULFATE ION[5 atoms] pdb_complex 86 613 precipitant 5i81 100.0 A 1 A ASM_HUMAN U 1 A SO4 582-584 Sphingomyelin phosphodiesterase SULFATE ION[5 atoms] pdb_complex 86 613 precipitant 5i81 100.0 A 1 A ASM_HUMAN V 1 A SO4 460:490:491 Sphingomyelin phosphodiesterase SULFATE ION[5 atoms] pdb_complex 86 613 precipitant 5i81 100.0 A 1 A ASM_HUMAN W 1 A SO4 564-567 Sphingomyelin phosphodiesterase SULFATE ION[5 atoms] pdb_complex 86 613 precipitant 5i85 100.0 A 1 A ASM_HUMAN P 4 A SO4 237:238 Sphingomyelin phosphodiesterase SULFATE ION[5 atoms] pdb_complex 86 613 precipitant 5i85 100.0 A 1 A ASM_HUMAN S 1 A SO4 142 Sphingomyelin phosphodiesterase SULFATE ION[5 atoms] pdb_complex 86 613 precipitant 5i85 100.0 A 1 A ASM_HUMAN T 1 A SO4 273:374:505 Sphingomyelin phosphodiesterase SULFATE ION[5 atoms] pdb_complex 85 613 precipitant 5jg8 100.0 A 1 A ASM_HUMAN L 1 A ACT 208:210:280:320:321:459:461 Sphingomyelin phosphodiesterase ACETATE ION[4 atoms]