type start end name pdb_id identity asym_id_homo oper_homo auth_asym_id_homo mol_id_homo asym_id_con oper_con auth_asym_id_con mol_id_con sites description_homo description_con length 1 215 id 1 215 HMGB1_HUMAN title 1 215 RecName: Full=High mobility group protein B1;AltName: Full=High mobility group protein 1; Short=HMG-1; seq 1 215 MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE uniprot 1 215 CHAIN /note="High mobility group protein B1" /id="PRO_0000048526" uniprot 9 79 DNA_BIND /note="HMG box 1" uniprot 95 163 DNA_BIND /note="HMG box 2" uniprot 1 97 REGION /note="Sufficient for interaction with HAVCR2" uniprot 3 15 REGION /note="LPS binding (delipidated)" uniprot 76 95 REGION /note="Disordered" uniprot 80 96 REGION /note="LPS binding (Lipid A)" uniprot 89 108 REGION /note="Cytokine-stimulating activity" uniprot 150 183 REGION /note="Binding to AGER/RAGE" uniprot 161 215 REGION /note="Disordered" uniprot 76 94 COMPBIAS /note="Basic and acidic residues" uniprot 161 187 COMPBIAS /note="Basic and acidic residues" uniprot 188 215 COMPBIAS /note="Acidic residues" uniprot 1 10 BINDING /ligand="heparin" /ligand_id="ChEBI:CHEBI:28304" disorder 1 16 predicted_by_DISOPRED disorder 28 28 predicted_by_DISOPRED disorder 30 37 predicted_by_DISOPRED disorder 63 64 predicted_by_DISOPRED disorder 75 76 predicted_by_DISOPRED disorder 79 95 predicted_by_DISOPRED disorder 164 215 predicted_by_DISOPRED pdb_monomer 1 166 monomer 2yrq 100.0 A A HMGB1_HUMAN 1-166 pdb_complex 2 84 hetero 2ly4 100.0 A 1 A HMGB1_HUMAN B 1 B P53_HUMAN 6-8:10:13:16:17:20:21:24:28:35:36:38:39:42:46 High mobility group protein B1 Cellular tumor antigen p53[47 aa] pdb_complex 9 158 hetero 6cij 100.0 G 1 N HMGB1_HUMAN A 1 A RAG1_MOUSE 87:90:91 High mobility group protein B1 V(D)J recombination-activating protein 1[614 aa] pdb_complex 89 163 hetero 8i9m 100.0 A 1 A HMGB1_HUMAN B 1 B RAGE_HUMAN 102:105:139:140:142:145-149:153-156 High mobility group protein B1 Advanced glycosylation end product-specific recept.. pdb_complex 17 165 nucleotide 2gzk 67.1 C 1 A Q6J415_HUMAN:Q548R9_RAT A 1 B 19:23:26:27:30:36:38:80:82-85:87:97:100:102:103:106:122:123:126:127:130:133:152:155:159:163 Sex-determining region on Y / HMGB1 5'-D(*GP*GP*GP*AP*TP*CP*TP*AP*AP*AP*CP*AP*AP*TP*GP.. pdb_complex 17 165 nucleotide 2gzk 67.1 C 1 A Q6J415_HUMAN:Q548R9_RAT B 1 C 17:18:38:42:43:46:47:49:50:61:64:68:80:82:90:91:95-97:99:103:107:110:122 Sex-determining region on Y / HMGB1 5'-D(*GP*CP*AP*TP*TP*GP*TP*TP*TP*AP*GP*AP*TP*CP*CP.. pdb_complex 8 78 nucleotide 1ckt 100.0 C 1 A HMG1_RAT A 1 B 12:14:16:38:39:42:43:46:49 HIGH MOBILITY GROUP 1 PROTEIN DNA (5'-D(*CP*CP*(5IU)P*CP*TP*CP*TP*GP*GP*AP*CP*CP.. pdb_complex 8 78 nucleotide 1ckt 100.0 C 1 A HMG1_RAT B 1 C 11-13:17:20:21:24:36:38:41 HIGH MOBILITY GROUP 1 PROTEIN DNA (5'-D(*GP*GP*AP*AP*GP*GP*TP*CP*CP*AP*GP*AP*GP*.. pdb_complex 8 80 nucleotide 4qr9 100.0 A 1 A HMGB1_RAT C 1 C 8:10:11:13:17:20:21:24:36:38:41 High mobility group protein B1 DNA (5'-D(*AP*TP*AP*TP*CP*GP*AP*TP*AP*T)-3') pdb_complex 8 80 nucleotide 4qr9 100.0 A 1 A HMGB1_RAT D 1 D 8:14-16:38:39:42:43:46:49 High mobility group protein B1 DNA (5'-D(*AP*TP*AP*TP*CP*GP*AP*TP*AP*T)-3') pdb_complex 8 80 nucleotide 4qr9 100.0 A 1 A HMGB1_RAT F 1 F 8:78 High mobility group protein B1 DNA (5'-D(*AP*TP*AP*TP*CP*GP*AP*TP*AP*T)-3') pdb_complex 11 144 nucleotide 5zdz 100.0 E 1 N HMGB1_MOUSE I 1 G 12:13:21:28:38:102:122:123:126:127 HMGB1 A-B box DNA (39-MER) pdb_complex 11 144 nucleotide 5zdz 100.0 E 1 N HMGB1_MOUSE K 1 M 14:16:38:39:42:43:46:49:103:122:126 HMGB1 A-B box DNA chain M pdb_complex 11 144 nucleotide 5ze2 100.0 E 1 N HMGB1_MOUSE H 1 G 21:28:38:102:123:126:130 HMGB1 A-B box DNA (40-MER) pdb_complex 11 144 nucleotide 5ze2 100.0 E 1 N HMGB1_MOUSE J 1 M 14:16:38:39:42:43:46:49:103:122 HMGB1 A-B box DNA (40-MER) pdb_complex 15 138 nucleotide 6cg0 100.0 K 1 N HMGB1_HUMAN H 1 G 17:21:24:35:36:38:102:103:110:126:127:134 High mobility group protein B1 DNA (60-MER) pdb_complex 15 138 nucleotide 6cg0 100.0 K 1 N HMGB1_HUMAN J 1 M 16:38:42:45:46:49:96:97:103:110:122 High mobility group protein B1 DNA (41-MER) pdb_complex 9 158 nucleotide 6cij 100.0 G 1 N HMGB1_HUMAN K 1 M 14-16:38:42:46:49:86:97:103:110:122 High mobility group protein B1 DNA (41-MER) pdb_complex 9 158 nucleotide 6cij 100.0 G 1 N HMGB1_HUMAN F 1 G 11:12:24:35:102:122:126:127:130:134 High mobility group protein B1 DNA (60-MER) pdb_complex 19 159 nucleotide 6cik 100.0 E 1 N HMGB1_HUMAN H 1 G 21:38:102:122:123:126:127:130:133:134 High mobility group protein B1 Nicked 23RSS intermediate reverse strand pdb_complex 19 159 nucleotide 6cik 100.0 E 1 N HMGB1_HUMAN J 1 M 38:42:46:103:122:126 High mobility group protein B1 Nicked 23RSS intermediate forward strand pdb_complex 99 159 nucleotide 6cil 100.0 E 1 N HMGB1_HUMAN H 1 G 100:102:127:131:134 High mobility group protein B1 Intact 23RSS substrate reverse strand pdb_complex 19 159 nucleotide 6cim 100.0 E 1 N HMGB1_HUMAN I 1 G 20:21:102:122:123:126:127:130:133:134 High mobility group protein B1 Intact 23RSS substrate reverse strand pdb_complex 19 159 nucleotide 6cim 100.0 E 1 N HMGB1_HUMAN J 1 J 42:46:103:122:126 High mobility group protein B1 Intact 23RSS substrate forward strand pdb_complex 99 136 nucleotide 6oem 100.0 I 1 N HMGB1_HUMAN E 1 G 102:122:126:127:130:133:134 High mobility group protein B1 DNA (57-MER) pdb_complex 99 136 nucleotide 6oen 100.0 I 1 N HMGB1_HUMAN E 1 G 102:122:126:127:130:133:134 High mobility group protein B1 DNA (57-MER) pdb_complex 99 136 nucleotide 6oem 100.0 I 1 N HMGB1_HUMAN H 1 J 103:106:114:118:119:122:126 High mobility group protein B1 DNA (57-MER) pdb_complex 99 136 nucleotide 6oen 100.0 I 1 N HMGB1_HUMAN H 1 J 103:106:110:114:118:119:122:126 High mobility group protein B1 DNA (57-MER) pdb_complex 101 155 nucleotide 6oem 100.0 J 1 H HMGB1_HUMAN F 1 I 101-103:123:126:127:130:134 High mobility group protein B1 DNA (46-MER) pdb_complex 101 155 nucleotide 6oen 100.0 J 1 H HMGB1_HUMAN F 1 I 101-103:126:127:130:131:134 High mobility group protein B1 DNA (46-MER) pdb_complex 101 155 nucleotide 6oem 100.0 J 1 H HMGB1_HUMAN G 1 F 103:106:107:110:122 High mobility group protein B1 DNA (46-MER) pdb_complex 101 155 nucleotide 6oen 100.0 J 1 H HMGB1_HUMAN G 1 F 103:107:122 High mobility group protein B1 DNA (46-MER) pdb_complex 99 136 nucleotide 6oer 100.0 I 1 H HMGB1_HORSE G 1 G 102:122:123:127:133 High mobility group protein B1 DNA (57-MER) pdb_complex 8 80 homo 4qr9 100.0 A 1 A HMGB1_RAT B 1 B HMGB1_RAT 8:35:37:38:80 High mobility group protein B1 High mobility group protein B1[75 aa] pdb_complex 93 171 precipitant 1hsm 100.0 A 1 A HMG1_CRIGR B 1 A BME 106:107:122:126 HIGH MOBILITY GROUP PROTEIN 1 BETA-MERCAPTOETHANOL[4 atoms]