Contact Molecules for Homologous Proteins

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PID QueryLength Homolgous Sequence in PDB UniProt Query TITLE
3962048 317 34 P02649(APOE_HUMAN) RecName: Full=Apolipoprotein E ; Short=Apo-E;Flags: Precursor;
QUERYSEQ 
MKVLWAALLVTFLAGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEE
LRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEK
VQAAVGTSAAPVPSDNH
[BLAST file for PDB] (plain) (bar) (multiple alignment) [BLAST for UniProt: (plain) (bar) (multiple alignment) (PSSM file) ]

UniProt Feature Tables [P02649(APOE_HUMAN)]

317
region name description
1-18 SIGNAL
19-317 CHAIN /note="Apolipoprotein E" /id="PRO_0000001987"
80-101 REPEAT /note="1"
102-123 REPEAT /note="2"
124-145 REPEAT /note="3"
146-167 REPEAT /note="4"
168-189 REPEAT /note="5"
190-211 REPEAT /note="6"
212-233 REPEAT /note="7"
234-255 REPEAT /note="8"
80-255 REGION /note="8 X 22 AA approximate tandem repeats"
158-168 REGION /note="LDL and other lipoprotein receptors binding" ECO:0000269|PubMed:2063194"
210-290 REGION /note="Lipid-binding and lipoprotein association" ECO:0000269|PubMed:8071364"
266-317 REGION /note="Homooligomerization"
278-290 REGION /note="Specificity for association with VLDL"
162-165 BINDING /ligand="heparin" /ligand_id="ChEBI:CHEBI:28304"
229-236 BINDING /ligand="heparin" /ligand_id="ChEBI:CHEBI:28304"
1-317 DISORDER predicted by DISOPRED

MONOMER
317
pdb_id a1 identity[%]2 description
2l7b A 98.3 APOE_HUMAN Apolipoprotein E 
1.a1:asym_id for the homologue. 2.identity[%]2:sequence identity between the query and the homologue.
HETERO
317 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
6v7m[1] B APOE_HUMAN Apolipoprotein E[83 aa] A 100.0
/100.0		 28
/28		 APOE_HUMAN Apolipoprotein E
6v7m[1] A APOE_HUMAN Apolipoprotein E[64 aa] B 100.0
/100.0		 28
/28		 APOE_HUMAN Apolipoprotein E
8grx[2] B LIRA6_HUMAN Leukocyte immunoglobulin-like receptor subfamily A.. A 100.0
/99.3		 15
/15		 APOE_HUMAN Apolipoprotein E
8grx[2] D LIRA6_HUMAN Leukocyte immunoglobulin-like receptor subfamily A.. A 100.0
/99.3		 8
/8		 APOE_HUMAN Apolipoprotein E
6iwb[2] B BCL2_HUMAN BCL2_HUMAN Apoptosis regulator Bcl-2,Apoptosis regulator Bcl-.. A 56.0
/91.5		 25
/25		 APOE_HUMAN Apolipoprotein E
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
COMPOUND
317 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
6ncn[1] B KJM
1-(3-chlorophenyl)cyclobutane-1-carboximidamide[14.. 		A 100.0
/99.3		 8
/8		 APOE_HUMAN Apolipoprotein E
6nco[1] B KQP
1-[5-chloro-4'-(2-hydroxypropan-2-yl)[1,1'-bipheny.. 		A 100.0
/99.3		 11
/11		 APOE_HUMAN Apolipoprotein E
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
METAL
317 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
7fcr[2] B NA
SODIUM ION[1 atoms] 		A 100.0
/99.3		 2
/2		 APOE_HUMAN Apolipoprotein E
7fcr[2] C NA
SODIUM ION[1 atoms] 		A 100.0
/99.3		 5
/5		 APOE_HUMAN Apolipoprotein E
7fcs[1] B NA
SODIUM ION[1 atoms] 		A 100.0
/99.3		 3
/3		 APOE_HUMAN Apolipoprotein E
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
PRECIPITANT
317 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
6v7m[1] C PO4
PHOSPHATE ION[5 atoms] 		A 100.0
/100.0		 2
/2		 APOE_HUMAN Apolipoprotein E
6v7m[1] C PO4
PHOSPHATE ION[5 atoms] 		B 100.0
/100.0		 2
/2		 APOE_HUMAN Apolipoprotein E
7uvj[1] C GOL
GLYCEROL[6 atoms] 		A 100.0
/96.5		 2
/2		 APOE_HUMAN Apolipoprotein E
7uvj[1] F GOL
GLYCEROL[6 atoms] 		B 100.0
/96.5		 2
/2		 APOE_HUMAN Apolipoprotein E
8ce0[1] B GOL
GLYCEROL[6 atoms] 		A 100.0
/99.3		 5
/5		 A0A376KDN7_ECOLX APOE_HUMAN Maltodextrin-binding protein,Apolipoprotein E
7uvj[1] D PEG
DI(HYDROXYETHYL)ETHER[7 atoms] 		A 100.0
/96.5		 3
/3		 APOE_HUMAN Apolipoprotein E
7uvj[1] G PEG
DI(HYDROXYETHYL)ETHER[7 atoms] 		B 100.0
/96.5		 2
/2		 APOE_HUMAN Apolipoprotein E
7uvj[1] E ACT
ACETATE ION[4 atoms] 		A 100.0
/96.5		 1
/1		 APOE_HUMAN Apolipoprotein E
6iwb[1] E SO4
SULFATE ION[5 atoms] 		A 100.0
/91.5		 3
/3		 APOE_HUMAN Apolipoprotein E
6iwb[1] F SO4
SULFATE ION[5 atoms] 		A 50.0
/91.5		 2
/2		 APOE_HUMAN Apolipoprotein E
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.