Contact Molecules for Homologous Proteins | ||||
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PID | QueryLength | Homolgous Sequence in PDB | UniProt Query | TITLE |
3962048 | 317 | 38 | P02649(APOE_HUMAN) | RecName: Full=Apolipoprotein E ; Short=Apo-E;Flags: Precursor; |
QUERYSEQ |
MKVLWAALLVTFLAGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEE LRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEK VQAAVGTSAAPVPSDNH |
317 | region | name | description |
1-18 | SIGNAL | ||
19-317 | CHAIN | /note="Apolipoprotein E" /id="PRO_0000001987" | |
80-101 | REPEAT | /note="1" | |
102-123 | REPEAT | /note="2" | |
124-145 | REPEAT | /note="3" | |
146-167 | REPEAT | /note="4" | |
168-189 | REPEAT | /note="5" | |
190-211 | REPEAT | /note="6" | |
212-233 | REPEAT | /note="7" | |
234-255 | REPEAT | /note="8" | |
80-255 | REGION | /note="8 X 22 AA approximate tandem repeats" | |
158-168 | REGION | /note="LDL and other lipoprotein receptors binding" ECO:0000269|PubMed:2063194" | |
210-290 | REGION | /note="Lipid-binding and lipoprotein association" ECO:0000269|PubMed:8071364" | |
266-317 | REGION | /note="Homooligomerization" | |
278-290 | REGION | /note="Specificity for association with VLDL" | |
162-165 | BINDING | /ligand="heparin" /ligand_id="ChEBI:CHEBI:28304" | |
229-236 | BINDING | /ligand="heparin" /ligand_id="ChEBI:CHEBI:28304" | |
1-317 | DISORDER | predicted by DISOPRED |
MONOMER | |||||||
317 | |||||||
pdb_id | a1 | identity[%]2 | description | ||||
2l7b | A | 98.3 | APOE_HUMAN Apolipoprotein E | ||||
1.a1:asym_id for the homologue. 2.identity[%]2:sequence identity between the query and the homologue. |
HETERO | |||||||
317 | pdb_id | contact mol | homologue | ||||
a3 | description | a4 | identity[%]5 | Ncon6 | description | ||
6v7m[1] | B | APOE_HUMAN Apolipoprotein E[83 aa] | A | 100.0 /100.0 |
28 /28 |
APOE_HUMAN Apolipoprotein E | |
6v7m[1] | A | APOE_HUMAN Apolipoprotein E[64 aa] | B | 100.0 /100.0 |
28 /28 |
APOE_HUMAN Apolipoprotein E | |
8grx[2] | B | LIRA6_HUMAN Leukocyte immunoglobulin-like receptor subfamily A.. | A | 100.0 /99.3 |
15 /15 |
APOE_HUMAN Apolipoprotein E | |
8grx[2] | D | LIRA6_HUMAN Leukocyte immunoglobulin-like receptor subfamily A.. | A | 100.0 /99.3 |
8 /8 |
APOE_HUMAN Apolipoprotein E | |
6iwb[2] | B | BCL2_HUMAN BCL2_HUMAN Apoptosis regulator Bcl-2,Apoptosis regulator Bcl-.. | A | 56.0 /91.5 |
25 /25 |
APOE_HUMAN Apolipoprotein E | |
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue. | |||||||
COMPOUND | |||||||
317 | pdb_id | contact mol | homologue | ||||
a3 | description | a4 | identity[%]5 | Ncon6 | description | ||
6ncn[1] | B |
KJM
1-(3-chlorophenyl)cyclobutane-1-carboximidamide[14.. |
A | 100.0 /99.3 |
8 /8 |
APOE_HUMAN Apolipoprotein E | |
6nco[1] | B |
KQP
1-[5-chloro-4'-(2-hydroxypropan-2-yl)[1,1'-bipheny.. |
A | 100.0 /99.3 |
11 /11 |
APOE_HUMAN Apolipoprotein E | |
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue. | |||||||
METAL | |||||||
317 | pdb_id | contact mol | homologue | ||||
a3 | description | a4 | identity[%]5 | Ncon6 | description | ||
7fcr[2] | B |
NA
SODIUM ION[1 atoms] |
A | 100.0 /99.3 |
2 /2 |
APOE_HUMAN Apolipoprotein E | |
7fcr[2] | C |
NA
SODIUM ION[1 atoms] |
A | 100.0 /99.3 |
5 /5 |
APOE_HUMAN Apolipoprotein E | |
7fcs[1] | B |
NA
SODIUM ION[1 atoms] |
A | 100.0 /99.3 |
3 /3 |
APOE_HUMAN Apolipoprotein E | |
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue. | |||||||
HOMO | |||||||
317 | pdb_id | contact mol | homologue | ||||
a3 | description | a4 | identity[%]5 | Ncon6 | description | ||
6clz[4] | C | APOA1_HUMAN Apolipoprotein A-I[211 aa] | B | 28.9 /28.5 |
38 /49 |
APOA1_HUMAN Apolipoprotein A-I | |
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue. | |||||||
PRECIPITANT | |||||||
317 | pdb_id | contact mol | homologue | ||||
a3 | description | a4 | identity[%]5 | Ncon6 | description | ||
6v7m[1] | C |
PO4
PHOSPHATE ION[5 atoms] |
A | 100.0 /100.0 |
2 /2 |
APOE_HUMAN Apolipoprotein E | |
6v7m[1] | C |
PO4
PHOSPHATE ION[5 atoms] |
B | 100.0 /100.0 |
2 /2 |
APOE_HUMAN Apolipoprotein E | |
7uvj[1] | C |
GOL
GLYCEROL[6 atoms] |
A | 100.0 /96.5 |
2 /2 |
APOE_HUMAN Apolipoprotein E | |
7uvj[1] | F |
GOL
GLYCEROL[6 atoms] |
B | 100.0 /96.5 |
2 /2 |
APOE_HUMAN Apolipoprotein E | |
8ce0[1] | B |
GOL
GLYCEROL[6 atoms] |
A | 100.0 /99.3 |
5 /5 |
A0A376KDN7_ECOLX APOE_HUMAN Maltodextrin-binding protein,Apolipoprotein E | |
7uvj[1] | D |
PEG
DI(HYDROXYETHYL)ETHER[7 atoms] |
A | 100.0 /96.5 |
3 /3 |
APOE_HUMAN Apolipoprotein E | |
7uvj[1] | G |
PEG
DI(HYDROXYETHYL)ETHER[7 atoms] |
B | 100.0 /96.5 |
2 /2 |
APOE_HUMAN Apolipoprotein E | |
7uvj[1] | E |
ACT
ACETATE ION[4 atoms] |
A | 100.0 /96.5 |
1 /1 |
APOE_HUMAN Apolipoprotein E | |
6iwb[1] | E |
SO4
SULFATE ION[5 atoms] |
A | 100.0 /91.5 |
3 /3 |
APOE_HUMAN Apolipoprotein E | |
6iwb[1] | F |
SO4
SULFATE ION[5 atoms] |
A | 50.0 /91.5 |
2 /2 |
APOE_HUMAN Apolipoprotein E | |
6clz[129] | BB |
PX4
1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE[46 ato.. |
B | 33.3 /28.5 |
3 /3 |
APOA1_HUMAN Apolipoprotein A-I | |
6clz[30] | CD |
PX4
1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE[46 ato.. |
B | 0.0 /28.5 |
1 /1 |
APOA1_HUMAN Apolipoprotein A-I | |
6clz[1] | BB |
PX4
1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE[46 ato.. |
C | 100.0 /28.5 |
1 /1 |
APOA1_HUMAN Apolipoprotein A-I | |
6cm1[2] | JF |
PX4
1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE[46 ato.. |
B | 0.0 /28.5 |
2 /2 |
APOA1_HUMAN Apolipoprotein A-I | |
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue. |