Contact Molecules for Homologous Proteins

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PID QueryLength Homolgous Sequence in PDB UniProt Query TITLE
14157 529 16 P52292(IMA1_HUMAN) RecName: Full=Importin subunit alpha-1 ;AltName: Full=Karyopherin subunit alpha-2;AltName: Full=RAG cohort protein 1;AltName: Full=SRP1-alpha;
QUERYSEQ 
MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASG
TSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVK
LLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQA
AEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
[BLAST file for PDB] (plain) (bar) (multiple alignment) [BLAST for UniProt: (plain) (bar) (multiple alignment) (PSSM file) ]

UniProt Feature Tables [P52292(IMA1_HUMAN)]

529
region name description
2-529 CHAIN /note="Importin subunit alpha-1" /id="PRO_0000120722"
2-60 DOMAIN /note="IBB"
71-111 REPEAT /note="ARM 1; truncated"
112-151 REPEAT /note="ARM 2"
152-193 REPEAT /note="ARM 3"
200-244 REPEAT /note="ARM 4"
246-282 REPEAT /note="ARM 5"
283-322 REPEAT /note="ARM 6"
325-364 REPEAT /note="ARM 7"
367-409 REPEAT /note="ARM 8"
410-456 REPEAT /note="ARM 9"
457-496 REPEAT /note="ARM 10; atypical"
1-27 REGION /note="Disordered"
43-72 REGION /note="Disordered"
142-238 REGION /note="NLS binding site (major)"
315-403 REGION /note="NLS binding site (minor)"
55-72 COMPBIAS /note="Polar residues"
1-529 DISORDER predicted by DISOPRED

MONOMER
529
pdb_id a1 identity[%]2 description
5h43 A 100.0 IMA1_HUMAN Importin subunit alpha-1
7cru B 100.0 IMA1_HUMAN Importin subunit alpha-1
4wv6 A 100.0 IMA1_HUMAN Importin subunit alpha-1
3fey C 100.0 IMA2_HUMAN Importin subunit alpha-2
8fzk D 100.0 IMA1_HUMAN Importin subunit alpha-1
3wpt B 100.0 IMA1_HUMAN Importin subunit alpha-1
7cru D 100.0 IMA1_HUMAN Importin subunit alpha-1
3wpt A 100.0 IMA1_HUMAN Importin subunit alpha-1
8fzk C 100.0 IMA1_HUMAN Importin subunit alpha-1
8fzk B 100.0 IMA1_HUMAN Importin subunit alpha-1
7n8j A 100.0 IMA1_HUMAN Importin subunit alpha-1
3fex C 100.0 IMA2_HUMAN Importin subunit alpha-2
8fzk A 100.0 IMA1_HUMAN Importin subunit alpha-1
1qgk B 100.0 IMA2_HUMAN PROTEIN (IMPORTIN ALPHA-2 SUBUNIT)
8gcn B 100.0 IMA1_HUMAN Importin subunit alpha-1
1qgr B 100.0 IMA2_HUMAN PROTEIN (IMPORTIN ALPHA-2 SUBUNIT) 
1.a1:asym_id for the homologue. 2.identity[%]2:sequence identity between the query and the homologue.
HETERO
529 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
1qgk A IMB1_HUMAN PROTEIN (IMPORTIN BETA SUBUNIT)[876 aa] B 100.0
/100.0		 25
/25		 IMA2_HUMAN PROTEIN (IMPORTIN ALPHA-2 SUBUNIT)
1qgr A IMB1_HUMAN PROTEIN (IMPORTIN BETA SUBUNIT)[872 aa] B 100.0
/100.0		 14
/14		 IMA2_HUMAN PROTEIN (IMPORTIN ALPHA-2 SUBUNIT)
8gcn A IMB1_HUMAN Importin subunit beta-1[876 aa] B 100.0
/100.0		 19
/19		 IMA1_HUMAN Importin subunit alpha-1
3fex A NCBP1_HUMAN Nuclear cap-binding protein subunit 1[756 aa] C 100.0
/100.0		 39
/39		 IMA2_HUMAN Importin subunit alpha-2
3fey A NCBP1_HUMAN Nuclear cap-binding protein subunit 1[761 aa] C 100.0
/100.0		 40
/40		 IMA2_HUMAN Importin subunit alpha-2
4wv6 B TAF8_HUMAN Transcription initiation factor TFIID subunit 8[9 .. A 100.0
/100.0		 20
/20		 IMA1_HUMAN Importin subunit alpha-1
4wv6 C TAF8_HUMAN Transcription initiation factor TFIID subunit 8[3 .. A 100.0
/100.0		 8
/8		 IMA1_HUMAN Importin subunit alpha-1
5h43 B KAT8_HUMAN Histone acetyltransferase KAT8[10 aa] A 100.0
/100.0		 21
/21		 IMA1_HUMAN Importin subunit alpha-1
5h43 C KAT8_HUMAN Histone acetyltransferase KAT8[15 aa] A 100.0
/100.0		 30
/30		 IMA1_HUMAN Importin subunit alpha-1
7cru A HNRPK_HUMAN Heterogeneous nuclear ribonucleoprotein K[20 aa] B 100.0
/100.0		 44
/44		 IMA1_HUMAN Importin subunit alpha-1
7cru C HNRPK_HUMAN Heterogeneous nuclear ribonucleoprotein K[20 aa] D 100.0
/100.0		 42
/42		 IMA1_HUMAN Importin subunit alpha-1
7n8j B BIMAX2[25 aa] A 100.0
/100.0		 57
/57		 IMA1_HUMAN Importin subunit alpha-1
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
METAL
529 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
8fzk F MG
MAGNESIUM ION[1 atoms] 		C 100.0
/100.0		 4
/4		 IMA1_HUMAN Importin subunit alpha-1
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
HOMO
529 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
8fzk B IMA1_HUMAN Importin subunit alpha-1[422 aa] A 100.0
/100.0		 42
/42		 IMA1_HUMAN Importin subunit alpha-1
8fzk A IMA1_HUMAN Importin subunit alpha-1[419 aa] B 100.0
/100.0		 43
/43		 IMA1_HUMAN Importin subunit alpha-1
8fzk D IMA1_HUMAN Importin subunit alpha-1[424 aa] C 100.0
/100.0		 40
/40		 IMA1_HUMAN Importin subunit alpha-1
8fzk C IMA1_HUMAN Importin subunit alpha-1[422 aa] D 100.0
/100.0		 37
/37		 IMA1_HUMAN Importin subunit alpha-1
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
PRECIPITANT
529 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
3wpt C PEG
DI(HYDROXYETHYL)ETHER[7 atoms] 		A 100.0
/100.0		 2
/2		 IMA1_HUMAN Importin subunit alpha-1
3wpt D PEG
DI(HYDROXYETHYL)ETHER[7 atoms] 		A 100.0
/100.0		 3
/3		 IMA1_HUMAN Importin subunit alpha-1
3wpt E PEG
DI(HYDROXYETHYL)ETHER[7 atoms] 		A 100.0
/100.0		 5
/5		 IMA1_HUMAN Importin subunit alpha-1
3wpt F PEG
DI(HYDROXYETHYL)ETHER[7 atoms] 		A 100.0
/100.0		 1
/1		 IMA1_HUMAN Importin subunit alpha-1
3wpt G PEG
DI(HYDROXYETHYL)ETHER[7 atoms] 		A 100.0
/100.0		 1
/1		 IMA1_HUMAN Importin subunit alpha-1
3wpt H PEG
DI(HYDROXYETHYL)ETHER[7 atoms] 		A 100.0
/100.0		 6
/6		 IMA1_HUMAN Importin subunit alpha-1
3wpt I PEG
DI(HYDROXYETHYL)ETHER[7 atoms] 		A 100.0
/100.0		 1
/1		 IMA1_HUMAN Importin subunit alpha-1
3wpt J PEG
DI(HYDROXYETHYL)ETHER[7 atoms] 		A 100.0
/100.0		 3
/3		 IMA1_HUMAN Importin subunit alpha-1
3wpt K PEG
DI(HYDROXYETHYL)ETHER[7 atoms] 		A 100.0
/100.0		 3
/3		 IMA1_HUMAN Importin subunit alpha-1
3wpt L PEG
DI(HYDROXYETHYL)ETHER[7 atoms] 		A 100.0
/100.0		 2
/2		 IMA1_HUMAN Importin subunit alpha-1
3wpt M PEG
DI(HYDROXYETHYL)ETHER[7 atoms] 		A 100.0
/100.0		 4
/4		 IMA1_HUMAN Importin subunit alpha-1
3wpt N PEG
DI(HYDROXYETHYL)ETHER[7 atoms] 		B 100.0
/100.0		 4
/4		 IMA1_HUMAN Importin subunit alpha-1
3wpt O PEG
DI(HYDROXYETHYL)ETHER[7 atoms] 		B 100.0
/100.0		 2
/2		 IMA1_HUMAN Importin subunit alpha-1
3wpt P PEG
DI(HYDROXYETHYL)ETHER[7 atoms] 		B 100.0
/100.0		 3
/3		 IMA1_HUMAN Importin subunit alpha-1
3wpt Q PEG
DI(HYDROXYETHYL)ETHER[7 atoms] 		B 100.0
/100.0		 4
/4		 IMA1_HUMAN Importin subunit alpha-1
3wpt R PEG
DI(HYDROXYETHYL)ETHER[7 atoms] 		B 100.0
/100.0		 3
/3		 IMA1_HUMAN Importin subunit alpha-1
3wpt S PEG
DI(HYDROXYETHYL)ETHER[7 atoms] 		B 100.0
/100.0		 3
/3		 IMA1_HUMAN Importin subunit alpha-1
4wv6 D EDO
1,2-ETHANEDIOL[4 atoms] 		A 100.0
/100.0		 2
/2		 IMA1_HUMAN Importin subunit alpha-1
4wv6 E EDO
1,2-ETHANEDIOL[4 atoms] 		A 100.0
/100.0		 2
/2		 IMA1_HUMAN Importin subunit alpha-1
4wv6 F EDO
1,2-ETHANEDIOL[4 atoms] 		A 100.0
/100.0		 4
/4		 IMA1_HUMAN Importin subunit alpha-1
4wv6 G EDO
1,2-ETHANEDIOL[4 atoms] 		A 100.0
/100.0		 4
/4		 IMA1_HUMAN Importin subunit alpha-1
4wv6 H EDO
1,2-ETHANEDIOL[4 atoms] 		A 100.0
/100.0		 5
/5		 IMA1_HUMAN Importin subunit alpha-1
4wv6 I EDO
1,2-ETHANEDIOL[4 atoms] 		A 100.0
/100.0		 3
/3		 IMA1_HUMAN Importin subunit alpha-1
4wv6 J EDO
1,2-ETHANEDIOL[4 atoms] 		A 100.0
/100.0		 4
/4		 IMA1_HUMAN Importin subunit alpha-1
4wv6 K EDO
1,2-ETHANEDIOL[4 atoms] 		A 100.0
/100.0		 3
/3		 IMA1_HUMAN Importin subunit alpha-1
4wv6 L EDO
1,2-ETHANEDIOL[4 atoms] 		A 100.0
/100.0		 3
/3		 IMA1_HUMAN Importin subunit alpha-1
4wv6 M EDO
1,2-ETHANEDIOL[4 atoms] 		A 100.0
/100.0		 3
/3		 IMA1_HUMAN Importin subunit alpha-1
4wv6 N EDO
1,2-ETHANEDIOL[4 atoms] 		A 100.0
/100.0		 2
/2		 IMA1_HUMAN Importin subunit alpha-1
4wv6 O EDO
1,2-ETHANEDIOL[4 atoms] 		A 100.0
/100.0		 3
/3		 IMA1_HUMAN Importin subunit alpha-1
7cru E ACT
ACETATE ION[4 atoms] 		B 100.0
/100.0		 2
/2		 IMA1_HUMAN Importin subunit alpha-1
7cru F ACT
ACETATE ION[4 atoms] 		D 100.0
/100.0		 1
/1		 IMA1_HUMAN Importin subunit alpha-1
7cru H ACT
ACETATE ION[4 atoms] 		D 100.0
/100.0		 4
/4		 IMA1_HUMAN Importin subunit alpha-1
7cru I ACT
ACETATE ION[4 atoms] 		D 100.0
/100.0		 4
/4		 IMA1_HUMAN Importin subunit alpha-1
7cru J ACT
ACETATE ION[4 atoms] 		D 100.0
/100.0		 1
/1		 IMA1_HUMAN Importin subunit alpha-1
7cru G GOL
GLYCEROL[6 atoms] 		D 100.0
/100.0		 4
/4		 IMA1_HUMAN Importin subunit alpha-1
8fzk E MES
2-(N-MORPHOLINO)-ETHANESULFONIC ACID[12 atoms] 		A 100.0
/100.0		 3
/3		 IMA1_HUMAN Importin subunit alpha-1
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.