Contact Molecules for Homologous Proteins


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PID QueryLength Homolgous Sequence in PDB UniProt Query TITLE
11199 492 24 O15393(TMPS2_HUMAN) RecName: Full=Transmembrane protease serine 2 ; EC=3.4.21.122 ;AltName: Full=Serine protease 10 ;Contains: RecName: Full=Transmembrane protease serine 2 non-catalytic chain;Contains: RecName: Full=Transmembrane protease serine 2 catalytic chain;Flags: Precursor;
QUERYSEQ
MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVR
LYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEK
PLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKN
NIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRADG
[BLAST file for PDB] (plain) (bar) (multiple alignment) [BLAST for UniProt: (plain) (bar) (multiple alignment) (PSSM file) ]

UniProt Feature Tables [O15393(TMPS2_HUMAN)]

492
region name description
1-255 CHAIN /note="Transmembrane protease serine 2 non-catalytic chain" /id="PRO_0000027855"
256-492 CHAIN /note="Transmembrane protease serine 2 catalytic chain" /id="PRO_0000027856"
1-84 TOPO_DOM /note="Cytoplasmic"
85-105 TRANSMEM /note="Helical; Signal-anchor for type II membrane protein"
106-492 TOPO_DOM /note="Extracellular"
112-149 DOMAIN /note="LDL-receptor class A"
150-242 DOMAIN /note="SRCR"
256-489 DOMAIN /note="Peptidase S1"
296-296 ACT_SITE /note="Charge relay system"
345-345 ACT_SITE /note="Charge relay system"
441-441 ACT_SITE /note="Charge relay system"
1-492 DISORDER predicted by DISOPRED

MONOMER
492
pdb_id a1 identity[%]2 description
8vgt B 99.4 TMPS2_HUMAN Transmembrane protease serine 2
8hd8 C 100.0 TMPS2_HUMAN Transmembrane protease serine 2 catalytic chain
1.a1:asym_id for the homologue. 2.identity[%]2:sequence identity between the query and the homologue.
HETERO
492 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
7xyd[8] B TMPS2_HUMAN Transmembrane protease serine 2 catalytic chain[24.. A 100.0
/100.0
25
/25
TMPS2_HUMAN Transmembrane protease serine 2 catalytic chain
8v04[3] B TMPS2_HUMAN Transmembrane protease serine 2[238 aa] A 100.0
/100.0
21
/21
TMPS2_HUMAN Transmembrane protease serine 2 non-catalytic chai..
7xyd[4] A TMPS2_HUMAN Transmembrane protease serine 2 catalytic chain[12.. B 100.0
/100.0
26
/28
TMPS2_HUMAN Transmembrane protease serine 2 catalytic chain
7xyd[2] C TMPS2_HUMAN Transmembrane protease serine 2 catalytic chain[12.. D 100.0
/100.0
29
/29
TMPS2_HUMAN Transmembrane protease serine 2 catalytic chain
7y0e[2] C TMPS2_HUMAN Transmembrane protease serine 2 catalytic chain[13.. D 100.0
/100.0
29
/29
TMPS2_HUMAN Transmembrane protease serine 2 catalytic chain
8v04[3] A TMPS2_HUMAN Transmembrane protease serine 2 non-catalytic chai.. B 100.0
/100.0
24
/24
TMPS2_HUMAN Transmembrane protease serine 2
8vgt[1] A SPIKE_CVHN1 Spike protein S1[280 aa] B 100.0
/99.4
15
/15
TMPS2_HUMAN Transmembrane protease serine 2
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
COMPOUND
492 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
7meq[1] C GBS
4-carbamimidamidobenzoic acid[12 atoms]
A 100.0
/100.0
14
/14
TMPS2_HUMAN Transmembrane protease serine 2
7xyd[7] G GBS
4-carbamimidamidobenzoic acid[12 atoms]
B 100.0
/100.0
12
/12
TMPS2_HUMAN Transmembrane protease serine 2 catalytic chain
7xyd[7] E NAG
2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms]..
A 100.0
/100.0
3
/3
TMPS2_HUMAN Transmembrane protease serine 2 catalytic chain
7y0f[2] G I9V
2-[(1-carbamimidamido-4-chloranyl-isoquinolin-7-yl..
B 100.0
/100.0
18
/18
TMPS2_HUMAN Transmembrane protease serine 2 catalytic chain
8v1f[1] G TAM
TRIS(HYDROXYETHYL)AMINOMETHANE[11 atoms]
A 100.0
/100.0
6
/6
TMPS2_HUMAN Transmembrane protease serine 2 non-catalytic chai..
8v1f[2] N TAM
TRIS(HYDROXYETHYL)AMINOMETHANE[11 atoms]
B 100.0
/100.0
6
/6
TMPS2_HUMAN Transmembrane protease serine 2
8v1f[1] P TAM
TRIS(HYDROXYETHYL)AMINOMETHANE[11 atoms]
B 100.0
/100.0
5
/5
TMPS2_HUMAN Transmembrane protease serine 2
8v1f[2] O 7R8
6-oxidanylnaphthalene-2-carboximidamide[14 atoms]
B 100.0
/100.0
10
/10
TMPS2_HUMAN Transmembrane protease serine 2
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
METAL
492 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
7meq[1] D UNX
UNKNOWN ATOM OR ION[1 atoms]
A 100.0
/100.0
2
/2
TMPS2_HUMAN Transmembrane protease serine 2
7meq[1] E UNX
UNKNOWN ATOM OR ION[1 atoms]
A 100.0
/100.0
1
/1
TMPS2_HUMAN Transmembrane protease serine 2
8v04[1] E UNX
UNKNOWN ATOM OR ION[1 atoms]
A 100.0
/100.0
1
/1
TMPS2_HUMAN Transmembrane protease serine 2 non-catalytic chai..
8v1f[2] H UNX
UNKNOWN ATOM OR ION[1 atoms]
A 100.0
/100.0
2
/2
TMPS2_HUMAN Transmembrane protease serine 2 non-catalytic chai..
8v1f[2] H UNX
UNKNOWN ATOM OR ION[1 atoms]
B 100.0
/100.0
1
/1
TMPS2_HUMAN Transmembrane protease serine 2
8v1f[1] Z UNX
UNKNOWN ATOM OR ION[1 atoms]
C 100.0
/100.0
3
/3
TMPS2_HUMAN Transmembrane protease serine 2 non-catalytic chai..
7xyd[8] F CA
CALCIUM ION[1 atoms]
A 100.0
/100.0
6
/6
TMPS2_HUMAN Transmembrane protease serine 2 catalytic chain
8v04[1] J CA
CALCIUM ION[1 atoms]
B 100.0
/100.0
1
/1
TMPS2_HUMAN Transmembrane protease serine 2
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
OTHERPOLY
492 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
8v04[1] C 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. A 100.0
/100.0
6
/6
TMPS2_HUMAN Transmembrane protease serine 2 non-catalytic chai..
8v1f[1] F 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[al.. C 100.0
/100.0
6
/6
TMPS2_HUMAN Transmembrane protease serine 2 non-catalytic chai..
7meq[1] B 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. A 100.0
/100.0
3
/3
TMPS2_HUMAN Transmembrane protease serine 2
8v1f[1] E 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. A 100.0
/100.0
3
/3
TMPS2_HUMAN Transmembrane protease serine 2 non-catalytic chai..
8vgt[1] C 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. B 100.0
/99.4
2
/2
TMPS2_HUMAN Transmembrane protease serine 2
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
PRECIPITANT
492 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
7y0e[1] K GOL
GLYCEROL[6 atoms]
D 100.0
/100.0
12
/12
TMPS2_HUMAN Transmembrane protease serine 2 catalytic chain
8v04[5] D EDO
1,2-ETHANEDIOL[4 atoms]
A 100.0
/100.0
1
/1
TMPS2_HUMAN Transmembrane protease serine 2 non-catalytic chai..
8v04[3] F EDO
1,2-ETHANEDIOL[4 atoms]
A 100.0
/100.0
1
/1
TMPS2_HUMAN Transmembrane protease serine 2 non-catalytic chai..
8v04[2] L EDO
1,2-ETHANEDIOL[4 atoms]
A 100.0
/100.0
2
/2
TMPS2_HUMAN Transmembrane protease serine 2 non-catalytic chai..
8v04[3] K EDO
1,2-ETHANEDIOL[4 atoms]
B 100.0
/100.0
4
/4
TMPS2_HUMAN Transmembrane protease serine 2
8v04[1] L EDO
1,2-ETHANEDIOL[4 atoms]
B 100.0
/100.0
4
/4
TMPS2_HUMAN Transmembrane protease serine 2
8v04[1] O EDO
1,2-ETHANEDIOL[4 atoms]
B 100.0
/100.0
1
/1
TMPS2_HUMAN Transmembrane protease serine 2
8v04[1] P EDO
1,2-ETHANEDIOL[4 atoms]
B 100.0
/100.0
2
/2
TMPS2_HUMAN Transmembrane protease serine 2
8v1f[1] I EDO
1,2-ETHANEDIOL[4 atoms]
A 100.0
/100.0
1
/1
TMPS2_HUMAN Transmembrane protease serine 2 non-catalytic chai..
8v1f[1] M EDO
1,2-ETHANEDIOL[4 atoms]
A 100.0
/100.0
4
/4
TMPS2_HUMAN Transmembrane protease serine 2 non-catalytic chai..
8v1f[3] T EDO
1,2-ETHANEDIOL[4 atoms]
A 100.0
/100.0
1
/1
TMPS2_HUMAN Transmembrane protease serine 2 non-catalytic chai..
8v1f[1] L EDO
1,2-ETHANEDIOL[4 atoms]
B 100.0
/100.0
2
/2
TMPS2_HUMAN Transmembrane protease serine 2
8v1f[1] M EDO
1,2-ETHANEDIOL[4 atoms]
B 100.0
/100.0
5
/5
TMPS2_HUMAN Transmembrane protease serine 2
8v1f[2] Q EDO
1,2-ETHANEDIOL[4 atoms]
B 100.0
/100.0
3
/3
TMPS2_HUMAN Transmembrane protease serine 2
8v1f[1] R EDO
1,2-ETHANEDIOL[4 atoms]
B 100.0
/100.0
7
/7
TMPS2_HUMAN Transmembrane protease serine 2
8v1f[2] S EDO
1,2-ETHANEDIOL[4 atoms]
B 100.0
/100.0
5
/5
TMPS2_HUMAN Transmembrane protease serine 2
8v1f[1] T EDO
1,2-ETHANEDIOL[4 atoms]
B 100.0
/100.0
2
/2
TMPS2_HUMAN Transmembrane protease serine 2
8v1f[2] V EDO
1,2-ETHANEDIOL[4 atoms]
B 100.0
/100.0
5
/5
TMPS2_HUMAN Transmembrane protease serine 2
8v1f[1] AA EDO
1,2-ETHANEDIOL[4 atoms]
C 100.0
/100.0
3
/3
TMPS2_HUMAN Transmembrane protease serine 2 non-catalytic chai..
8v1f[1] IA EDO
1,2-ETHANEDIOL[4 atoms]
D 100.0
/100.0
5
/5
TMPS2_HUMAN Transmembrane protease serine 2
8v1f[1] MA EDO
1,2-ETHANEDIOL[4 atoms]
D 100.0
/100.0
3
/3
TMPS2_HUMAN Transmembrane protease serine 2
8v04[1] I CIT
CITRIC ACID[13 atoms]
B 100.0
/100.0
3
/3
TMPS2_HUMAN Transmembrane protease serine 2
8v1f[1] CA CIT
CITRIC ACID[13 atoms]
C 100.0
/100.0
2
/2
TMPS2_HUMAN Transmembrane protease serine 2 non-catalytic chai..
8v1f[1] Y CIT
CITRIC ACID[13 atoms]
C 100.0
/100.0
3
/4
TMPS2_HUMAN Transmembrane protease serine 2 non-catalytic chai..
8v1f[1] CA CIT
CITRIC ACID[13 atoms]
D 100.0
/100.0
4
/4
TMPS2_HUMAN Transmembrane protease serine 2
8v04[1] N PG4
TETRAETHYLENE GLYCOL[13 atoms]
B 100.0
/100.0
7
/7
TMPS2_HUMAN Transmembrane protease serine 2
8v1f[1] BA PG4
TETRAETHYLENE GLYCOL[13 atoms]
C 100.0
/100.0
6
/6
TMPS2_HUMAN Transmembrane protease serine 2 non-catalytic chai..
8v1f[1] BA PG4
TETRAETHYLENE GLYCOL[13 atoms]
D 100.0
/100.0
2
/2
TMPS2_HUMAN Transmembrane protease serine 2
8v1f[1] JA PG4
TETRAETHYLENE GLYCOL[13 atoms]
D 100.0
/100.0
11
/11
TMPS2_HUMAN Transmembrane protease serine 2
8v1f[1] X PEG
DI(HYDROXYETHYL)ETHER[7 atoms]
C 100.0
/100.0
3
/3
TMPS2_HUMAN Transmembrane protease serine 2 non-catalytic chai..
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.