Contact Molecules for Homologous Proteins

[Full Bars]
[SiteTable]


Summary Bars[100 %]


[Back to Search Page]
[Back to HOMCOS]

[SupCon3D]
[help] 		seq_id(%): [0] [30] [40] [50] [60] [70] [80] [90] [95] [100]
[show] [download] [help]
PID QueryLength Homolgous Sequence in PDB UniProt Query TITLE
22598 425 13 P84022(SMAD3_HUMAN) RecName: Full=Mothers against decapentaplegic homolog 3; Short=MAD homolog 3; Short=Mad3; Short=Mothers against DPP homolog 3; Short=hMAD-3;AltName: Full=JV15-2;AltName: Full=SMAD family member 3; Short=SMAD 3; Short=Smad3; Short=hSMAD3;
QUERYSEQ 
MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEF
PPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIG
GEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS
[BLAST file for PDB] (plain) (bar) (multiple alignment) [BLAST for UniProt: (plain) (bar) (multiple alignment) (PSSM file) ]

UniProt Feature Tables [P84022(SMAD3_HUMAN)]

425
region name description
2-425 CHAIN /note="Mothers against decapentaplegic homolog 3" /id="PRO_0000090856"
10-136 DOMAIN /note="MH1"
232-425 DOMAIN /note="MH2"
137-231 REGION /note="Linker"
165-208 REGION /note="Disordered"
271-324 REGION /note="Sufficient for interaction with XPO4"
64-64 BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105"
109-109 BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105"
121-121 BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105"
126-126 BINDING /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105"
1-425 DISORDER predicted by DISOPRED

MONOMER
425
pdb_id a1 identity[%]2 description
1mk2 A 100.0 SMAD3_HUMAN SMAD 3
1ozj C 100.0 SMAD3_HUMAN SMAD 3 
1.a1:asym_id for the homologue. 2.identity[%]2:sequence identity between the query and the homologue.
HETERO
425 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
1mk2[2] B ZFYV9_HUMAN Madh-interacting protein[38 aa] A 100.0
/100.0		 31
/31		 SMAD3_HUMAN SMAD 3
1u7f[1] B SMAD4_HUMAN Mothers against decapentaplegic homolog 4[193 aa] A 96.3
/100.0		 27
/28		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
1u7f[1] B SMAD4_HUMAN Mothers against decapentaplegic homolog 4[193 aa] C 100.0
/100.0		 20
/20		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
5xoc[3] B THIO_ECOLI FOXH1_HUMAN Thioredoxin 1,Forkhead box protein H1[133 aa] A 100.0
/100.0		 26
/26		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
NUCLEOTIDE
425 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
1mhd[2] A DNA C 100.0
/100.0		 9
/9		 SMAD3_HUMAN SMAD3
1mhd[1] B DNA C 100.0
/100.0		 4
/4		 SMAD3_HUMAN SMAD3
1mhd[1] B DNA D 100.0
/100.0		 7
/7		 SMAD3_HUMAN SMAD3
1ozj[2] A Smad binding element C 100.0
/100.0		 10
/10		 SMAD3_HUMAN SMAD 3
1ozj[2] B Smad binding element C 100.0
/100.0		 6
/6		 SMAD3_HUMAN SMAD 3
5od6[1] C DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*GP*CP*GP*CP*CP*TP.. A 100.0
/100.0		 5
/5		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
5od6[1] D DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*GP*CP*GP*CP*CP*TP.. A 100.0
/100.0		 9
/9		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
5odg[4] C DNA (5'-D(P*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP.. A 100.0
/100.0		 8
/8		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
5odg[4] D DNA (5'-D(P*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP.. A 100.0
/100.0		 5
/5		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
METAL
425 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
1ozj[2] E ZN
ZINC ION[1 atoms] 		C 100.0
/100.0		 4
/4		 SMAD3_HUMAN SMAD 3
5od6[6] E ZN
ZINC ION[1 atoms] 		A 100.0
/100.0		 4
/4		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
5odg[2] F CL
CHLORIDE ION[1 atoms] 		A 100.0
/100.0		 1
/1		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
HOMO
425 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
1mk2[2] A SMAD3_HUMAN SMAD 3[197 aa] A 100.0
/100.0		 12
/12		 SMAD3_HUMAN SMAD 3
1u7f[1] C SMAD3_HUMAN Mothers against decapentaplegic homolog 3[196 aa] A 100.0
/100.0		 23
/23		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
1u7f[1] A SMAD3_HUMAN Mothers against decapentaplegic homolog 3[198 aa] C 95.7
/100.0		 23
/24		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
5xoc[3] A SMAD3_HUMAN Mothers against decapentaplegic homolog 3[194 aa] A 100.0
/100.0		 17
/17		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
5xoc[3] A SMAD3_HUMAN Mothers against decapentaplegic homolog 3[194 aa] A 100.0
/100.0		 14
/14		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
1ozj[2] D SMAD3_HUMAN SMAD 3[124 aa] C 100.0
/100.0		 1
/1		 SMAD3_HUMAN SMAD 3
5od6[2] B SMAD3_HUMAN Mothers against decapentaplegic homolog 3[126 aa] A 100.0
/100.0		 5
/5		 SMAD3_HUMAN Mothers against decapentaplegic homolog 3
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
PRECIPITANT
425 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
1mk2[4] C ACY
ACETIC ACID[4 atoms] 		A 100.0
/100.0		 6
/6		 SMAD3_HUMAN SMAD 3
1mk2[2] D ACY
ACETIC ACID[4 atoms] 		A 100.0
/100.0		 6
/6		 SMAD3_HUMAN SMAD 3
1mk2[2] E ACY
ACETIC ACID[4 atoms] 		A 100.0
/100.0		 3
/3		 SMAD3_HUMAN SMAD 3
1mk2[2] F ACY
ACETIC ACID[4 atoms] 		A 100.0
/100.0		 4
/4		 SMAD3_HUMAN SMAD 3
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.