Contact Molecules for Homologous Proteins

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PID QueryLength Homolgous Sequence in PDB UniProt Query TITLE
6445 675 64 Q8N3R9(PALS1_HUMAN) RecName: Full=Protein PALS1 ;AltName: Full=MAGUK p55 subfamily member 5;AltName: Full=Membrane protein, palmitoylated 5 ;AltName: Full=Protein associated with Lin-7 1 ;
QUERYSEQ 
MTTSHMNGHVTEESDSEVKNVDLASPEEHQKHREMAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKLAQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEIEDLFSSLKHIQHTLVDSQSQEDISLL
LQLVQNKDFQNAFKIHNAITVHMNKASPPFPLISNAQDLAQEVQTVLKPVHHKEGQELTALLNTPHIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDE
VLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLY
NANKNDDYDNEEILTYEEMSLYHQPANRKRPIILIGPQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVSRQAFEADIAAGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPP
SQERLRALLAKEGKNPKPEELREIIEKTREMEQNNGHYFDTAIVNSDLDKAYQELLRLINKLDTEPQWVPSTWLR
[BLAST file for PDB] (plain) (bar) (multiple alignment) [BLAST for UniProt: (plain) (bar) (multiple alignment) (PSSM file) ]

UniProt Feature Tables [Q8N3R9(PALS1_HUMAN)]

675
region name description
1-675 CHAIN /note="Protein PALS1" /id="PRO_0000094580"
120-177 DOMAIN /note="L27 1"
179-235 DOMAIN /note="L27 2"
256-336 DOMAIN /note="PDZ"
345-417 DOMAIN /note="SH3"
479-660 DOMAIN /note="Guanylate kinase-like"
1-345 REGION /note="Required for the correct localization of PALS1 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions"
1-34 REGION /note="Disordered"
21-140 REGION /note="Interaction with PARD6B"
51-78 REGION /note="Disordered"
181-243 REGION /note="Interaction with LIN7C"
10-34 COMPBIAS /note="Basic and acidic residues"
57-78 COMPBIAS /note="Basic and acidic residues"
486-493 BINDING /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616"
1-469 DISORDER predicted by DISOPRED

MONOMER
675
pdb_id a1 identity[%]2 description
4wsi A 100.0 MPP5_HUMAN MPP5_HUMAN MAGUK p55 subfamily member 5
3uit D 100.0 INADL_MOUSE MPP5_HUMAN LIN7B_RAT InaD-like protein, MAGUK p55 subfamily member 5, Protein lin-7 homolog B
3uat A 40.8 DLG1_RAT Disks large homolog 1
1jxo B 40.0 DLG4_RAT postsynaptic density protein 
1.a1:asym_id for the homologue. 2.identity[%]2:sequence identity between the query and the homologue.
HETERO
675 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
1y76[2] A MPDZ_RAT protein associated to tight junctions[62 aa] B 100.0
/100.0		 4
/4		 MPP5_HUMAN MAGUK p55 subfamily member 5
1y76[2] C MPDZ_RAT protein associated to tight junctions[62 aa] B 100.0
/100.0		 26
/26		 MPP5_HUMAN MAGUK p55 subfamily member 5
4uu5[1] B CRUM1_HUMAN PROTEIN CRUMBS HOMOLOG 1[14 aa] A 100.0
/100.0		 13
/13		 MPP5_HUMAN MAGUK P55 SUBFAMILY MEMBER 5
4wsi[2] C CRB_DROME Protein crumbs[18 aa] A 100.0
/100.0		 37
/37		 MPP5_HUMAN MPP5_HUMAN MAGUK p55 subfamily member 5
7m4r[1] C VEMP_SARS2 Envelope small membrane protein[9 aa] A 100.0
/100.0		 11
/11		 MPP5_HUMAN MPP5_HUMAN MAGUK p55 subfamily member 5
7ntj[1] B VEMP_SARS Envelope small membrane protein[4 aa] A 100.0
/100.0		 13
/13		 MPP5_HUMAN MAGUK p55 subfamily member 5
7ntj[1] D VEMP_SARS Envelope small membrane protein[7 aa] C 100.0
/100.0		 13
/13		 MPP5_HUMAN MAGUK p55 subfamily member 5
7ntk[3] C VEMP_SARS2 Envelope small membrane protein[7 aa] A 100.0
/100.0		 12
/12		 MPP5_HUMAN MAGUK p55 subfamily member 5
7ntk[1] H VEMP_SARS2 Envelope small membrane protein[6 aa] F 100.0
/100.0		 14
/14		 MPP5_HUMAN MAGUK p55 subfamily member 5
7qcs[2] C VEMP_SARS2 Envelope small membrane protein[5 aa] A 100.0
/100.0		 14
/14		 PALS1_HUMAN Protein PALS1
1vf6[4] A INADL_HUMAN PALS1-associated tight junction protein[58 aa] C 100.0
/91.7		 20
/20		 MPP5_MOUSE MAGUK p55 subfamily member 5
1vf6[4] B INADL_HUMAN PALS1-associated tight junction protein[60 aa] C 50.0
/91.7		 2
/2		 MPP5_MOUSE MAGUK p55 subfamily member 5
2vwf[1] B GAB2_HUMAN GRB2-ASSOCIATED-BINDING PROTEIN 2[14 aa] A 71.4
/51.2		 7
/10		 GRB2_HUMAN GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
2w0z[1] B GAB2_HUMAN GRB2-ASSOCIATED-BINDING PROTEIN 2[9 aa] A 71.4
/51.2		 7
/10		 GRB2_HUMAN GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
1gcq[1] C VAV_MOUSE VAV PROTO-ONCOGENE[69 aa] A 50.0
/43.4		 10
/10		 GRB2_HUMAN GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
1gcq[1] C VAV_MOUSE VAV PROTO-ONCOGENE[69 aa] B 33.3
/43.4		 12
/13		 GRB2_HUMAN GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
1io6[1] B A LIGAND PEPTIDE[10 aa] A 60.0
/43.4		 10
/10		 GRB2_HUMAN GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
1rzx[1] B Acetylated VKESLV Peptide[7 aa] A 58.3
/41.7		 12
/12		 O97111_DROME CG5884-PA
1x8s[1] B Pals1 peptide[9 aa] A 46.7
/41.7		 15
/16		 CG5884-PA
1n7f[2] C 8-mer peptide from interacting protein (liprin)[8 .. A 45.5
/41.5		 11
/14		 GRIP1_RAT AMPA receptor interacting protein GRIP
3tvt[1] B Q9NH88_DROME Partner of Inscuteable[14 aa] A 64.7
/41.1		 17
/17		 DLG1_DROME DLG1_DROME Disks large 1 tumor suppressor protein
3uat[1] B phosphor-LGN peptide[15 aa] A 68.4
/40.8		 19
/19		 DLG1_RAT Disks large homolog 1
1nf3[3] A CDC42_HUMAN G25K GTP-binding protein, placental isoform[194 aa.. C 33.3
/40.7		 6
/23		 PAR6B_MOUSE PAR-6B
6nid[2] E NRX1A_HUMAN Neurexin-1[5 aa] A 55.6
/40.2		 9
/9		 CSKP_HUMAN Peripheral plasma membrane protein CASK
6nid[1] D NRX1A_HUMAN Neurexin-1[6 aa] B 50.0
/40.2		 12
/12		 CSKP_HUMAN Peripheral plasma membrane protein CASK
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
COMPOUND
675 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
4uu5[1] K PUN
2,2,4,4,6,6,8-heptamethylnonane[16 atoms] 		A 100.0
/100.0		 2
/2		 MPP5_HUMAN MAGUK P55 SUBFAMILY MEMBER 5
1lvg[1] C ADP
ADENOSINE-5'-DIPHOSPHATE[27 atoms] 		A 41.7
/42.1		 12
/13		 KGUA_MOUSE Guanylate kinase
1lvg[1] D 5GP
GUANOSINE-5'-MONOPHOSPHATE[24 atoms] 		A 52.9
/42.1		 17
/17		 KGUA_MOUSE Guanylate kinase
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
METAL
675 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
4uu5[3] F CL
CHLORIDE ION[1 atoms] 		A 100.0
/100.0		 1
/1		 MPP5_HUMAN MAGUK P55 SUBFAMILY MEMBER 5
4uu5[1] G CL
CHLORIDE ION[1 atoms] 		A 100.0
/100.0		 2
/2		 MPP5_HUMAN MAGUK P55 SUBFAMILY MEMBER 5
4uu5[1] I CL
CHLORIDE ION[1 atoms] 		A 100.0
/100.0		 1
/1		 MPP5_HUMAN MAGUK P55 SUBFAMILY MEMBER 5
4uu5[1] L CL
CHLORIDE ION[1 atoms] 		A 100.0
/100.0		 1
/1		 MPP5_HUMAN MAGUK P55 SUBFAMILY MEMBER 5
4uu5[1] J NA
SODIUM ION[1 atoms] 		A 100.0
/100.0		 3
/3		 MPP5_HUMAN MAGUK P55 SUBFAMILY MEMBER 5
3o46[3] B UNX
UNKNOWN ATOM OR ION[1 atoms] 		A 0.0
/45.1		 1
/1		 MPP7_HUMAN MAGUK p55 subfamily member 7
3o46[6] B UNX
UNKNOWN ATOM OR ION[1 atoms] 		A 75.0
/45.1		 4
/4		 MPP7_HUMAN MAGUK p55 subfamily member 7
3o46[9] C UNX
UNKNOWN ATOM OR ION[1 atoms] 		A 0.0
/45.1		 1
/1		 MPP7_HUMAN MAGUK p55 subfamily member 7
3o46[9] C UNX
UNKNOWN ATOM OR ION[1 atoms] 		A 0.0
/45.1		 2
/2		 MPP7_HUMAN MAGUK p55 subfamily member 7
3o46[3] E UNX
UNKNOWN ATOM OR ION[1 atoms] 		A 0.0
/45.1		 4
/4		 MPP7_HUMAN MAGUK p55 subfamily member 7
3o46[12] F UNX
UNKNOWN ATOM OR ION[1 atoms] 		A 0.0
/45.1		 1
/1		 MPP7_HUMAN MAGUK p55 subfamily member 7
3o46[3] H UNX
UNKNOWN ATOM OR ION[1 atoms] 		A 0.0
/45.1		 1
/1		 MPP7_HUMAN MAGUK p55 subfamily member 7
3o46[6] H UNX
UNKNOWN ATOM OR ION[1 atoms] 		A 50.0
/45.1		 2
/2		 MPP7_HUMAN MAGUK p55 subfamily member 7
3o46[3] I UNX
UNKNOWN ATOM OR ION[1 atoms] 		A 100.0
/45.1		 1
/1		 MPP7_HUMAN MAGUK p55 subfamily member 7
1lvg[1] B K
POTASSIUM ION[1 atoms] 		A 33.3
/42.1		 3
/3		 KGUA_MOUSE Guanylate kinase
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
HOMO
675 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
1y76[2] D MPP5_HUMAN MAGUK p55 subfamily member 5[60 aa] B 100.0
/100.0		 6
/6		 MPP5_HUMAN MAGUK p55 subfamily member 5
7m4r[1] B MPP5_HUMAN MPP5_HUMAN MAGUK p55 subfamily member 5[270 aa] A 100.0
/100.0		 20
/20		 MPP5_HUMAN MPP5_HUMAN MAGUK p55 subfamily member 5
7m4r[1] A MPP5_HUMAN MPP5_HUMAN MAGUK p55 subfamily member 5[360 aa] B 100.0
/100.0		 19
/19		 MPP5_HUMAN MPP5_HUMAN MAGUK p55 subfamily member 5
7qcs[2] B PALS1_HUMAN Protein PALS1[98 aa] A 100.0
/100.0		 9
/9		 PALS1_HUMAN Protein PALS1
7qcs[1] E PALS1_HUMAN Protein PALS1[82 aa] A 100.0
/100.0		 2
/2		 PALS1_HUMAN Protein PALS1
7qcs[1] A PALS1_HUMAN Protein PALS1[97 aa] E 100.0
/100.0		 1
/1		 PALS1_HUMAN Protein PALS1
3o46[3] A MPP7_HUMAN MAGUK p55 subfamily member 7[84 aa] A 58.3
/45.1		 12
/12		 MPP7_HUMAN MAGUK p55 subfamily member 7
3o46[3] A MPP7_HUMAN MAGUK p55 subfamily member 7[84 aa] A 22.2
/45.1		 9
/9		 MPP7_HUMAN MAGUK p55 subfamily member 7
1gri[4] B GRB2_HUMAN GROWTH FACTOR BOUND PROTEIN 2[211 aa] A 26.7
/43.4		 15
/47		 GRB2_HUMAN GROWTH FACTOR BOUND PROTEIN 2
1n7f[2] B GRIP1_RAT AMPA receptor interacting protein GRIP[86 aa] A 40.0
/41.5		 5
/13		 GRIP1_RAT AMPA receptor interacting protein GRIP
4f4j[1] A KGUA_YEAST Guanylate kinase[189 aa] B 60.0
/41.5		 15
/15		 KGUA_YEAST Guanylate kinase
4f4j[1] A KGUA_YEAST Guanylate kinase[189 aa] B 45.5
/41.5		 22
/22		 KGUA_YEAST Guanylate kinase
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
PRECIPITANT
675 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
2qg1[1] B EDO
1,2-ETHANEDIOL[4 atoms] 		A 66.7
/41.4		 3
/4		 MPDZ_HUMAN Multiple PDZ domain protein
2qg1[1] C EDO
1,2-ETHANEDIOL[4 atoms] 		A 50.0
/41.4		 4
/7		 MPDZ_HUMAN Multiple PDZ domain protein
6nid[1] G EDO
1,2-ETHANEDIOL[4 atoms] 		B 0.0
/40.2		 4
/4		 CSKP_HUMAN Peripheral plasma membrane protein CASK
7ntk[2] J EDO
1,2-ETHANEDIOL[4 atoms] 		B 100.0
/100.0		 1
/2		 MPP5_HUMAN MAGUK p55 subfamily member 5
7ntk[1] K EDO
1,2-ETHANEDIOL[4 atoms] 		B 100.0
/100.0		 1
/1		 MPP5_HUMAN MAGUK p55 subfamily member 5
7ntk[1] M EDO
1,2-ETHANEDIOL[4 atoms] 		D 100.0
/100.0		 5
/5		 MPP5_HUMAN MAGUK p55 subfamily member 5
2vvk[1] B GOL
GLYCEROL[6 atoms] 		A 80.0
/44.2		 5
/6		 GRB2_HUMAN GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
4uu6[1] B GOL
GLYCEROL[6 atoms] 		A 100.0
/100.0		 6
/6		 MPP5_HUMAN MAGUK P55 SUBFAMILY MEMBER 5
3uit[2] E ACT
ACETATE ION[4 atoms] 		A 100.0
/100.0		 2
/3		 INADL_MOUSE MPP5_HUMAN LIN7B_RAT InaD-like protein, MAGUK p55 subfamily member 5, P..
3uit[4] G ACT
ACETATE ION[4 atoms] 		A 100.0
/100.0		 1
/2		 INADL_MOUSE MPP5_HUMAN LIN7B_RAT InaD-like protein, MAGUK p55 subfamily member 5, P..
3uit[2] H ACT
ACETATE ION[4 atoms] 		A 100.0
/100.0		 2
/5		 INADL_MOUSE MPP5_HUMAN LIN7B_RAT InaD-like protein, MAGUK p55 subfamily member 5, P..
3uit[2] J ACT
ACETATE ION[4 atoms] 		A 100.0
/100.0		 3
/3		 INADL_MOUSE MPP5_HUMAN LIN7B_RAT InaD-like protein, MAGUK p55 subfamily member 5, P..
3uit[1] K ACT
ACETATE ION[4 atoms] 		A 100.0
/100.0		 1
/5		 INADL_MOUSE MPP5_HUMAN LIN7B_RAT InaD-like protein, MAGUK p55 subfamily member 5, P..
3uit[1] O ACT
ACETATE ION[4 atoms] 		B 100.0
/100.0		 1
/3		 INADL_MOUSE MPP5_HUMAN LIN7B_RAT InaD-like protein, MAGUK p55 subfamily member 5, P..
4uu6[1] D ACT
ACETATE ION[4 atoms] 		A 100.0
/100.0		 1
/1		 MPP5_HUMAN MAGUK P55 SUBFAMILY MEMBER 5
7ntk[1] I FLC
CITRATE ANION[13 atoms] 		B 100.0
/100.0		 2
/2		 MPP5_HUMAN MAGUK p55 subfamily member 5
1gcq[1] D MRD
(4R)-2-METHYLPENTANE-2,4-DIOL[8 atoms] 		A 20.0
/43.4		 5
/5		 GRB2_HUMAN GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2
4f4j[1] C SO4
SULFATE ION[5 atoms] 		B 0.0
/41.5		 2
/2		 KGUA_YEAST Guanylate kinase
4f4j[2] D SO4
SULFATE ION[5 atoms] 		B 16.7
/41.5		 6
/6		 KGUA_YEAST Guanylate kinase
4f4j[2] E SO4
SULFATE ION[5 atoms] 		B 0.0
/41.5		 2
/2		 KGUA_YEAST Guanylate kinase
4f4j[2] F SO4
SULFATE ION[5 atoms] 		B 50.0
/41.5		 2
/2		 KGUA_YEAST Guanylate kinase
4f4j[2] G SO4
SULFATE ION[5 atoms] 		B 33.3
/41.5		 3
/3		 KGUA_YEAST Guanylate kinase
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.