Contact Molecules for Homologous Proteins

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PID QueryLength Homolgous Sequence in PDB UniProt Query TITLE
29474 1170 23 P20701(ITAL_HUMAN) RecName: Full=Integrin alpha-L ;AltName: Full=CD11 antigen-like family member A;AltName: Full=Leukocyte adhesion glycoprotein LFA-1 alpha chain; Short=LFA-1A;AltName: Full=Leukocyte function-associated molecule 1 alpha chain;AltName: CD_antigen=CD11a;Flags: Precursor;
QUERYSEQ 
MKDSCITVMAMALLSGFFFFAPASSYNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGAPGEGNSTGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTDGSILACDPGLSRTCDQNTYLSGLCYLFRQNLQGPMLQGRPGFQEC
IKGNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKRKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLH
KFASKPASEFVKILDTFEKLKDLFTELQKKIYVIEGTSKQDLTSFNMELSSSGISADLSRGHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNEPLTPEVRAGYLGYTVTWLPSRQKTSLLASGAPRYQHMGRVLLFQEPQGGGHWSQVQT
IHGTQIGSYFGGELCGVDVDQDGETELLLIGAPLFYGEQRGGRVFIYQRRQLGFEEVSELQGDPGYPLGRFGEAITALTDINGDGLVDVAVGAPLEEQGAVYIFNGRHGGLSPQPSQRIEGTQVLSGIQWFGRSIHGVKDLEGDGLADVA
VGAESQMIVLSSRPVVDMVTLMSFSPAEIPVHEVECSYSTSNKMKEGVNITICFQIKSLIPQFQGRLVANLTYTLQLDGHRTRRRGLFPGGRHELRRNIAVTTSMSCTDFSFHFPVCVQDLISPINVSLNFSLWEEEGTPRDQRAQGKDI
PPILRPSLHSETWEIPFEKNCGEDKKCEANLRVSFSPARSRALRLTAFASLSVELSLSNLEEDAYWVQLDLHFPPGLSFRKVEMLKPHSQIPVSCEELPEESRLLSRALSCNVSSPIFKAGHSVALQMMFNTLVNSSWGDSVELHANVTC
NNEDSDLLEDNSATTIIPILYPINILIQDQEDSTLYVSFTPKGPKIHQVKHMYQVRIQPSIHDHNIPTLEAVVGVPQPPSEGPITHQWSVQMEPPVPCHYEDLERLPDAAEPCLPGALFRCPVVFRQEILVQVIGTLELVGEIEASSMFS
LCSSLSISFNSSKHFHLYGSNASLAQVVMKVDVVYEKQMLYLYVLSGIGGLLLLLLIFIVLYKVGFFKRNLKEKMEAGRGVPNGIPAEDSEQLASGQEAGDPGCLKPLHEKDSESGGGKD
[BLAST file for PDB] (plain) (bar) (multiple alignment) [BLAST for UniProt: (plain) (bar) (multiple alignment) (PSSM file) ]

UniProt Feature Tables [P20701(ITAL_HUMAN)]

1170
region name description
1-25 SIGNAL
26-1170 CHAIN /note="Integrin alpha-L" /id="PRO_0000016292"
26-1090 TOPO_DOM /note="Extracellular"
1091-1111 TRANSMEM /note="Helical"
1112-1170 TOPO_DOM /note="Cytoplasmic"
31-82 REPEAT /note="FG-GAP 1"
83-141 REPEAT /note="FG-GAP 2"
156-327 DOMAIN /note="VWFA"
338-389 REPEAT /note="FG-GAP 3"
390-445 REPEAT /note="FG-GAP 4"
446-506 REPEAT /note="FG-GAP 5"
507-563 REPEAT /note="FG-GAP 6"
567-627 REPEAT /note="FG-GAP 7"
1128-1170 REGION /note="Disordered"
1154-1170 COMPBIAS /note="Basic and acidic residues"
468-468 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="1"
470-470 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="1"
472-472 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="1"
476-476 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="1"
530-530 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="2"
532-532 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="2"
534-534 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="2"
538-538 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="2"
590-590 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="3"
594-594 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="3"
598-598 BINDING /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="3"
1-1170 DISORDER predicted by DISOPRED

MONOMER
1170
pdb_id a1 identity[%]2 description
1rd4 B 100.0 ITAL_HUMAN Integrin alpha-L
2m3e A 100.0 ITAL_HUMAN Integrin alpha-L 
1.a1:asym_id for the homologue. 2.identity[%]2:sequence identity between the query and the homologue.
HETERO
1170 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
3eoa[4] A Efalizumab Fab fragment, light chain[214 aa] E 100.0
/100.0		 1
/1		 ITAL_HUMAN Integrin alpha-L
3eoa[4] C Efalizumab Fab fragment, heavy chain[215 aa] E 100.0
/100.0		 14
/14		 ITAL_HUMAN Integrin alpha-L
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
COMPOUND
1170 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
1rd4[4] E L08
1-ACETYL-4-(4-{4-[(2-ETHOXYPHENYL)THIO]-3-NITROPHE.. 		A 100.0
/100.0		 19
/19		 ITAL_HUMAN Integrin alpha-L
2ica[1] B 2IC
5-[(5S,9R)-9-(4-CYANOPHENYL)-3-(3,5-DICHLOROPHENYL.. 		A 100.0
/100.0		 12
/12		 ITAL_HUMAN Integrin alpha-L
2o7n[1] B 2O7
7A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-.. 		A 100.0
/100.0		 12
/12		 ITAL_HUMAN Integrin alpha-L
3m6f[1] B BJZ
6-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl.. 		A 100.0
/100.0		 15
/15		 ITAL_HUMAN Integrin alpha-L
7kc5[2] D BJZ
6-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl.. 		A 100.0
/100.0		 12
/12		 ITAL_HUMAN Integrin alpha-L
7kc6[2] C 803
LOVASTATIN[29 atoms] 		A 100.0
/100.0		 9
/9		 ITAL_HUMAN Integrin alpha-L
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
METAL
1170 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
1lfa[4] C MN
MANGANESE (II) ION[1 atoms] 		A 100.0
/100.0		 3
/3		 ITAL_HUMAN CD11A
1lfa[6] D CL
CHLORIDE ION[1 atoms] 		A 100.0
/100.0		 3
/3		 ITAL_HUMAN CD11A
1zoo[2] C MG
MAGNESIUM ION[1 atoms] 		A 100.0
/100.0		 5
/5		 ITAL_HUMAN LEUKOCYTE ADHESION GLYCOPROTEIN
7kc5[4] C MG
MAGNESIUM ION[1 atoms] 		A 100.0
/100.0		 6
/6		 ITAL_HUMAN Integrin alpha-L
3eob[2] G ZN
ZINC ION[1 atoms] 		C 100.0
/100.0		 6
/6		 ITAL_HUMAN Integrin alpha-L
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
HOMO
1170 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
1lfa[1] B ITAL_HUMAN CD11A[182 aa] A 100.0
/100.0		 5
/5		 ITAL_HUMAN CD11A
1lfa[1] A ITAL_HUMAN CD11A[183 aa] B 100.0
/100.0		 7
/7		 ITAL_HUMAN CD11A
1zoo[4] B ITAL_HUMAN LEUKOCYTE ADHESION GLYCOPROTEIN[183 aa] A 100.0
/100.0		 20
/20		 ITAL_HUMAN LEUKOCYTE ADHESION GLYCOPROTEIN
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
PRECIPITANT
1170 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
3m6f[1] C NO3
NITRATE ION[4 atoms] 		A 100.0
/100.0		 3
/3		 ITAL_HUMAN Integrin alpha-L
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.