HOMCOS(prot_sch_conbars.cgi):

		Contact Molecules for Homologous Proteins
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PID

QueryLength

Homolgous Sequence in PDB

UniProt Query

TITLE

13847

468

P08887(IL6RA_HUMAN)

RecName: Full=Interleukin-6 receptor subunit alpha ; Short=IL-6 receptor subunit alpha; Short=IL-6R subunit alpha; Short=IL-6R-alpha; Short=IL-6RA;AltName: Full=IL-6R 1;AltName: Full=Membrane glycoprotein 80; Short=gp80;AltName: CD_antigen=CD126;Contains: RecName: Full=Soluble interleukin-6 receptor subunit alpha ; Short=sIL6R ;Flags: Precursor;

QUERYSEQ

MLAVGCALLAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRPAGTVHLLVDVPPEEPQLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLV
RKFQNSPAEDFQEPCQYSQESQKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQ
GEWSEWSPEAMGTPWTESRSPPAENEVSTPMQALTTNKDDDNILFRDSANATSLPVQDSSSVPLPTFLVAGGSLAFGTLLCIAIVLRFKKTWKLRALKEGKTSMHPPYSLGQLVPERPRPTPVLVPLISPPVSPSSLGSDNTSSHNRPDA
RDPRSPYDISNTDYFFPR

[BLAST file for PDB] (plain) (bar) (multiple alignment) [BLAST for UniProt: (plain) (bar) (multiple alignment) (PSSM file) ]

UniProt Feature Tables [P08887(IL6RA_HUMAN)]

468
	region	name	description
	1-19	SIGNAL
	20-468	CHAIN	/note="Interleukin-6 receptor subunit alpha" /id="PRO_0000010895"
	20-355	CHAIN	/note="Soluble interleukin-6 receptor subunit alpha" /id="PRO_0000450730"
	20-365	TOPO_DOM	/note="Extracellular"
	366-386	TRANSMEM	/note="Helical"
	387-468	TOPO_DOM	/note="Cytoplasmic"
	26-112	DOMAIN	/note="Ig-like C2-type"
	113-217	DOMAIN	/note="Fibronectin type-III 1"
	218-316	DOMAIN	/note="Fibronectin type-III 2"
	303-328	REGION	/note="Disordered"
	421-468	REGION	/note="Disordered"
	311-328	COMPBIAS	/note="Polar residues"
	1-468	DISORDER	predicted by DISOPRED

MONOMER

468

pdb_id a¹ identity[%]² description

1n26 A 100.0 IL6A_HUMAN IL-6 Receptor alpha chain

1.a¹:asym_id for the homologue. 2.identity[%]²:sequence identity between the query and the homologue.

HETERO

468 pdb_id contact mol homologue

a³ description a⁴ identity[%]⁵ Ncon⁶ description

1p9m[2] B IL6_HUMAN Interleukin-6[163 aa] C 100.0
/100.0 15
/15 IL6RA_HUMAN Interleukin-6 receptor alpha chain

5fuc[1] B IL6_HUMAN INTERLEUKIN-6[160 aa] C 100.0
/99.0 18
/18 D6R9R8_HUMAN IL6RA_HUMAN INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA, INTERLEUKIN-..

8d82[2] B IL6_HUMAN Interleukin-6[169 aa] A 100.0
/100.0 12
/12 IL6RA_HUMAN Soluble interleukin-6 receptor subunit alpha

8qy5[4] B IL6_HUMAN Interleukin-6[157 aa] C 100.0
/100.0 11
/11 IL6RA_HUMAN Interleukin-6 receptor subunit alpha

8d82[2] C IL6RB_HUMAN Interleukin-6 receptor subunit beta[589 aa] A 100.0
/100.0 11
/11 IL6RA_HUMAN Soluble interleukin-6 receptor subunit alpha

8d82[2] F IL6RB_HUMAN Interleukin-6 receptor subunit beta[589 aa] A 100.0
/100.0 6
/6 IL6RA_HUMAN Soluble interleukin-6 receptor subunit alpha

8iow[2] C Light chain of Sarilumab Fab[212 aa] A 100.0
/100.0 6
/6 IL6RA_HUMAN Interleukin-6 receptor subunit alpha

8iow[1] D Heavy chain of Sarilumab Fab[207 aa] A 100.0
/100.0 12
/12 IL6RA_HUMAN Interleukin-6 receptor subunit alpha

8j6f[1] A Heavy chain of Tocilizumab Fab[211 aa] C 100.0
/100.0 14
/14 IL6RA_HUMAN Interleukin-6 receptor subunit alpha

8j6f[1] D IL6RA_HUMAN IL6R-D2 peptide[10 aa] C 100.0
/100.0 6
/6 IL6RA_HUMAN Interleukin-6 receptor subunit alpha

8qy4[6] B IL6RB_MOUSE Interleukin-6 receptor subunit beta[583 aa] E 41.7
/31.7 12
/12 I11RA_HUMAN Interleukin-11 receptor subunit alpha

8qy4[6] D IL6RB_MOUSE Interleukin-6 receptor subunit beta[583 aa] E 0.0
/31.7 6
/6 I11RA_HUMAN Interleukin-11 receptor subunit alpha

7dc8[2] A Switch Ab Fab light chain[212 aa] C 100.0
/99.5 5
/5 IL6RA_HUMAN Interleukin-6 receptor subunit alpha

7dc8[2] B Switch Ab Fab heavy chain[209 aa] C 100.0
/99.5 9
/9 IL6RA_HUMAN Interleukin-6 receptor subunit alpha

5fuc[1] E VHH6[110 aa] C 100.0
/99.0 10
/10 D6R9R8_HUMAN IL6RA_HUMAN INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA, INTERLEUKIN-..

5fuc[1] A IL6_HUMAN INTERLEUKIN-6[152 aa] D 100.0
/99.0 12
/12 D6R9R8_HUMAN IL6RA_HUMAN INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA, INTERLEUKIN-..

5fuc[1] F VHH6[124 aa] D 100.0
/99.0 10
/10 D6R9R8_HUMAN IL6RA_HUMAN INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA, INTERLEUKIN-..

1p9m[2] A IL6RB_HUMAN Interleukin-6 receptor beta chain[298 aa] C 100.0
/100.0 12
/12 IL6RA_HUMAN Interleukin-6 receptor alpha chain

1p9m[2] A IL6RB_HUMAN Interleukin-6 receptor beta chain[298 aa] C 100.0
/100.0 8
/8 IL6RA_HUMAN Interleukin-6 receptor alpha chain

8dps[8] A IL6RB_HUMAN Interleukin-6 receptor subunit beta[297 aa] C 36.4
/33.9 11
/11 I11RA_HUMAN Interleukin-11 receptor subunit alpha

8dps[8] D IL6RB_HUMAN Interleukin-6 receptor subunit beta[297 aa] C 0.0
/33.9 4
/4 I11RA_HUMAN Interleukin-11 receptor subunit alpha

8d74[2] A IL6RB_HUMAN Interleukin-6 receptor subunit beta[392 aa] C 36.4
/34.7 11
/11 CNTFR_HUMAN Ciliary neurotrophic factor receptor subunit alpha..

8d74[1] B CNTF_HUMAN Ciliary neurotrophic factor[174 aa] C 14.3
/34.7 14
/14 CNTFR_HUMAN Ciliary neurotrophic factor receptor subunit alpha..

8d7h[3] B CLCF1_HUMAN Cardiotrophin-like cytokine factor 1[178 aa] A 12.5
/33.9 16
/17 CNTFR_HUMAN Ciliary neurotrophic factor receptor subunit alpha..

8dpt[2] A IL6RB_HUMAN Interleukin-6 receptor subunit beta[398 aa] C 33.3
/34.2 15
/15 I11RA_HUMAN Interleukin-11 receptor subunit alpha

8dpt[2] D IL6RB_HUMAN Interleukin-6 receptor subunit beta[398 aa] C 0.0
/34.2 3
/3 I11RA_HUMAN Interleukin-11 receptor subunit alpha

8d7e[1] B H4H25311P2 antibody Fab fragment light chain[215 a.. A 33.3
/33.9 9
/9 CNTFR_HUMAN Ciliary neurotrophic factor receptor subunit alpha..

8d7e[1] C H4H25311P2 antibody Fab fragment heavy chain[217 a.. A 27.3
/33.9 11
/11 CNTFR_HUMAN Ciliary neurotrophic factor receptor subunit alpha..

8d7e[1] E REGN8938 antibody Fab fragment heavy chain[214 aa].. A 0.0
/33.9 3
/11 CNTFR_HUMAN Ciliary neurotrophic factor receptor subunit alpha..

8dps[10] B IL11_HUMAN Interleukin-11[165 aa] C 6.7
/33.9 15
/18 I11RA_HUMAN Interleukin-11 receptor subunit alpha

8qy4[2] A IL11_HUMAN Interleukin-11[165 aa] E 0.0
/31.7 10
/15 I11RA_HUMAN Interleukin-11 receptor subunit alpha

1f45[1] B I12A_HUMAN INTERLEUKIN-12 ALPHA CHAIN[133 aa] A 25.0
/30.4 20
/21 I12B_HUMAN INTERLEUKIN-12 BETA CHAIN

3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

COMPOUND

468 pdb_id contact mol homologue

a³ description a⁴ identity[%]⁵ Ncon⁶ description

1n26[6] D NAG
2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms].. A 100.0
/100.0 5
/5 IL6A_HUMAN IL-6 Receptor alpha chain

1n26[6] E NAG
2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms].. A 100.0
/100.0 3
/3 IL6A_HUMAN IL-6 Receptor alpha chain

1n26[1] E NAG
2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms].. A 100.0
/100.0 3
/3 IL6A_HUMAN IL-6 Receptor alpha chain

5fuc[2] G NAG
2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms].. C 100.0
/99.0 3
/3 D6R9R8_HUMAN IL6RA_HUMAN INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA, INTERLEUKIN-..

6o4p[7] E NAG
2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms].. A 50.0
/35.0 4
/4 I11RA_HUMAN Interleukin-11 receptor subunit alpha

8d74[2] P NAG
2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms].. C 0.0
/34.7 1
/1 CNTFR_HUMAN Ciliary neurotrophic factor receptor subunit alpha..

8d82[2] S NAG
2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms].. A 100.0
/100.0 3
/3 IL6RA_HUMAN Soluble interleukin-6 receptor subunit alpha

8iow[1] F NAG
2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms].. A 100.0
/100.0 3
/3 IL6RA_HUMAN Interleukin-6 receptor subunit alpha

1n26[2] H CYS
CYSTEINE[7 atoms] A 100.0
/100.0 5
/5 IL6A_HUMAN IL-6 Receptor alpha chain

7dc8[2] H ATP
ADENOSINE-5'-TRIPHOSPHATE[31 atoms] C 100.0
/99.5 1
/1 IL6RA_HUMAN Interleukin-6 receptor subunit alpha

3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

OTHERPOLY

468 pdb_id contact mol homologue

a³ description a⁴ identity[%]⁵ Ncon⁶ description

1n26[2] B 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-al.. A 100.0
/100.0 9
/9 IL6A_HUMAN IL-6 Receptor alpha chain

8dps[4] H beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet.. C 0.0
/33.9 3
/3 I11RA_HUMAN Interleukin-11 receptor subunit alpha

8dpu[6] T beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet.. C 16.7
/35.3 6
/6 I11RA_HUMAN Interleukin-11 receptor subunit alpha

6o4p[1] C alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(.. A 0.0
/35.0 5
/5 I11RA_HUMAN Interleukin-11 receptor subunit alpha

1n26[2] C 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. A 100.0
/100.0 5
/5 IL6A_HUMAN IL-6 Receptor alpha chain

6o4p[1] D 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. B 0.0
/35.4 4
/4 I11RA_HUMAN Interleukin-11 receptor subunit alpha

8d74[5] F 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. C 40.0
/34.7 5
/5 CNTFR_HUMAN Ciliary neurotrophic factor receptor subunit alpha..

8d7e[3] H 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. A 50.0
/33.9 2
/4 CNTFR_HUMAN Ciliary neurotrophic factor receptor subunit alpha..

8d7e[3] I 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. A 0.0
/33.9 2
/2 CNTFR_HUMAN Ciliary neurotrophic factor receptor subunit alpha..

8d82[2] G 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. A 100.0
/100.0 1
/1 IL6RA_HUMAN Soluble interleukin-6 receptor subunit alpha

8qy4[2] I 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. E 40.0
/31.7 5
/5 I11RA_HUMAN Interleukin-11 receptor subunit alpha

8qy4[2] J 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a.. E 0.0
/31.7 5
/5 I11RA_HUMAN Interleukin-11 receptor subunit alpha

1f45[1] C alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-be.. A 0.0
/30.4 3
/7 I12B_HUMAN INTERLEUKIN-12 BETA CHAIN

3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

HOMO

468 pdb_id contact mol homologue

a³ description a⁴ identity[%]⁵ Ncon⁶ description

1n26[1] A IL6A_HUMAN IL-6 Receptor alpha chain[299 aa] A 100.0
/100.0 11
/11 IL6A_HUMAN IL-6 Receptor alpha chain

1n26[1] A IL6A_HUMAN IL-6 Receptor alpha chain[299 aa] A 100.0
/100.0 15
/15 IL6A_HUMAN IL-6 Receptor alpha chain

8iow[1] B IL6RA_HUMAN Interleukin-6 receptor subunit alpha[14 aa] A 100.0
/100.0 8
/8 IL6RA_HUMAN Interleukin-6 receptor subunit alpha

1bqu[1] B IL6RB_HUMAN PROTEIN (GP130)[215 aa] A 33.3
/30.2 9
/9 IL6RB_HUMAN PROTEIN (GP130)

3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

PRECIPITANT

468 pdb_id contact mol homologue

a³ description a⁴ identity[%]⁵ Ncon⁶ description

1bqu[2] C SO4
SULFATE ION[5 atoms] A 0.0
/30.2 4
/4 IL6RB_HUMAN PROTEIN (GP130)

1bqu[8] E SO4
SULFATE ION[5 atoms] A 100.0
/30.2 2
/2 IL6RB_HUMAN PROTEIN (GP130)

1n26[2] F SO4
SULFATE ION[5 atoms] A 100.0
/100.0 3
/3 IL6A_HUMAN IL-6 Receptor alpha chain

1n26[2] G SO4
SULFATE ION[5 atoms] A 100.0
/100.0 3
/3 IL6A_HUMAN IL-6 Receptor alpha chain

6o4p[1] I SO4
SULFATE ION[5 atoms] A 0.0
/35.0 1
/3 I11RA_HUMAN Interleukin-11 receptor subunit alpha

6o4p[2] J SO4
SULFATE ION[5 atoms] A 33.3
/35.0 3
/3 I11RA_HUMAN Interleukin-11 receptor subunit alpha

6o4p[1] L SO4
SULFATE ION[5 atoms] B 0.0
/35.4 2
/2 I11RA_HUMAN Interleukin-11 receptor subunit alpha

6o4p[1] M SO4
SULFATE ION[5 atoms] B 0.0
/35.4 3
/3 I11RA_HUMAN Interleukin-11 receptor subunit alpha

6o4p[1] P SO4
SULFATE ION[5 atoms] B 0.0
/35.4 1
/1 I11RA_HUMAN Interleukin-11 receptor subunit alpha

7dc8[2] K SO4
SULFATE ION[5 atoms] C 100.0
/99.5 3
/3 IL6RA_HUMAN Interleukin-6 receptor subunit alpha

1bqu[1] F GOL
GLYCEROL[6 atoms] A 50.0
/30.2 6
/6 IL6RB_HUMAN PROTEIN (GP130)

1bqu[1] G GOL
GLYCEROL[6 atoms] A 25.0
/30.2 8
/8 IL6RB_HUMAN PROTEIN (GP130)

3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

MONOMER
468
	pdb_id	a¹	identity[%]²	description
	1n26	A	100.0	IL6A_HUMAN IL-6 Receptor alpha chain
	1.a¹:asym_id for the homologue. 2.identity[%]²:sequence identity between the query and the homologue.

HETERO
468	pdb_id	contact mol		homologue
	pdb_id	a³	description	a⁴	identity[%]⁵	Ncon⁶	description
	1p9m[2]	B	IL6_HUMAN Interleukin-6[163 aa]	C	100.0 /100.0	15 /15	IL6RA_HUMAN Interleukin-6 receptor alpha chain
	5fuc[1]	B	IL6_HUMAN INTERLEUKIN-6[160 aa]	C	100.0 /99.0	18 /18	D6R9R8_HUMAN IL6RA_HUMAN INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA, INTERLEUKIN-..
	8d82[2]	B	IL6_HUMAN Interleukin-6[169 aa]	A	100.0 /100.0	12 /12	IL6RA_HUMAN Soluble interleukin-6 receptor subunit alpha
	8qy5[4]	B	IL6_HUMAN Interleukin-6[157 aa]	C	100.0 /100.0	11 /11	IL6RA_HUMAN Interleukin-6 receptor subunit alpha
	8d82[2]	C	IL6RB_HUMAN Interleukin-6 receptor subunit beta[589 aa]	A	100.0 /100.0	11 /11	IL6RA_HUMAN Soluble interleukin-6 receptor subunit alpha
	8d82[2]	F	IL6RB_HUMAN Interleukin-6 receptor subunit beta[589 aa]	A	100.0 /100.0	6 /6	IL6RA_HUMAN Soluble interleukin-6 receptor subunit alpha
	8iow[2]	C	Light chain of Sarilumab Fab[212 aa]	A	100.0 /100.0	6 /6	IL6RA_HUMAN Interleukin-6 receptor subunit alpha
	8iow[1]	D	Heavy chain of Sarilumab Fab[207 aa]	A	100.0 /100.0	12 /12	IL6RA_HUMAN Interleukin-6 receptor subunit alpha
	8j6f[1]	A	Heavy chain of Tocilizumab Fab[211 aa]	C	100.0 /100.0	14 /14	IL6RA_HUMAN Interleukin-6 receptor subunit alpha
	8j6f[1]	D	IL6RA_HUMAN IL6R-D2 peptide[10 aa]	C	100.0 /100.0	6 /6	IL6RA_HUMAN Interleukin-6 receptor subunit alpha
	8qy4[6]	B	IL6RB_MOUSE Interleukin-6 receptor subunit beta[583 aa]	E	41.7 /31.7	12 /12	I11RA_HUMAN Interleukin-11 receptor subunit alpha
	8qy4[6]	D	IL6RB_MOUSE Interleukin-6 receptor subunit beta[583 aa]	E	0.0 /31.7	6 /6	I11RA_HUMAN Interleukin-11 receptor subunit alpha
	7dc8[2]	A	Switch Ab Fab light chain[212 aa]	C	100.0 /99.5	5 /5	IL6RA_HUMAN Interleukin-6 receptor subunit alpha
	7dc8[2]	B	Switch Ab Fab heavy chain[209 aa]	C	100.0 /99.5	9 /9	IL6RA_HUMAN Interleukin-6 receptor subunit alpha
	5fuc[1]	E	VHH6[110 aa]	C	100.0 /99.0	10 /10	D6R9R8_HUMAN IL6RA_HUMAN INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA, INTERLEUKIN-..
	5fuc[1]	A	IL6_HUMAN INTERLEUKIN-6[152 aa]	D	100.0 /99.0	12 /12	D6R9R8_HUMAN IL6RA_HUMAN INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA, INTERLEUKIN-..
	5fuc[1]	F	VHH6[124 aa]	D	100.0 /99.0	10 /10	D6R9R8_HUMAN IL6RA_HUMAN INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA, INTERLEUKIN-..
	1p9m[2]	A	IL6RB_HUMAN Interleukin-6 receptor beta chain[298 aa]	C	100.0 /100.0	12 /12	IL6RA_HUMAN Interleukin-6 receptor alpha chain
	1p9m[2]	A	IL6RB_HUMAN Interleukin-6 receptor beta chain[298 aa]	C	100.0 /100.0	8 /8	IL6RA_HUMAN Interleukin-6 receptor alpha chain
	8dps[8]	A	IL6RB_HUMAN Interleukin-6 receptor subunit beta[297 aa]	C	36.4 /33.9	11 /11	I11RA_HUMAN Interleukin-11 receptor subunit alpha
	8dps[8]	D	IL6RB_HUMAN Interleukin-6 receptor subunit beta[297 aa]	C	0.0 /33.9	4 /4	I11RA_HUMAN Interleukin-11 receptor subunit alpha
	8d74[2]	A	IL6RB_HUMAN Interleukin-6 receptor subunit beta[392 aa]	C	36.4 /34.7	11 /11	CNTFR_HUMAN Ciliary neurotrophic factor receptor subunit alpha..
	8d74[1]	B	CNTF_HUMAN Ciliary neurotrophic factor[174 aa]	C	14.3 /34.7	14 /14	CNTFR_HUMAN Ciliary neurotrophic factor receptor subunit alpha..
	8d7h[3]	B	CLCF1_HUMAN Cardiotrophin-like cytokine factor 1[178 aa]	A	12.5 /33.9	16 /17	CNTFR_HUMAN Ciliary neurotrophic factor receptor subunit alpha..
	8dpt[2]	A	IL6RB_HUMAN Interleukin-6 receptor subunit beta[398 aa]	C	33.3 /34.2	15 /15	I11RA_HUMAN Interleukin-11 receptor subunit alpha
	8dpt[2]	D	IL6RB_HUMAN Interleukin-6 receptor subunit beta[398 aa]	C	0.0 /34.2	3 /3	I11RA_HUMAN Interleukin-11 receptor subunit alpha
	8d7e[1]	B	H4H25311P2 antibody Fab fragment light chain[215 a..	A	33.3 /33.9	9 /9	CNTFR_HUMAN Ciliary neurotrophic factor receptor subunit alpha..
	8d7e[1]	C	H4H25311P2 antibody Fab fragment heavy chain[217 a..	A	27.3 /33.9	11 /11	CNTFR_HUMAN Ciliary neurotrophic factor receptor subunit alpha..
	8d7e[1]	E	REGN8938 antibody Fab fragment heavy chain[214 aa]..	A	0.0 /33.9	3 /11	CNTFR_HUMAN Ciliary neurotrophic factor receptor subunit alpha..
	8dps[10]	B	IL11_HUMAN Interleukin-11[165 aa]	C	6.7 /33.9	15 /18	I11RA_HUMAN Interleukin-11 receptor subunit alpha
	8qy4[2]	A	IL11_HUMAN Interleukin-11[165 aa]	E	0.0 /31.7	10 /15	I11RA_HUMAN Interleukin-11 receptor subunit alpha
	1f45[1]	B	I12A_HUMAN INTERLEUKIN-12 ALPHA CHAIN[133 aa]	A	25.0 /30.4	20 /21	I12B_HUMAN INTERLEUKIN-12 BETA CHAIN
	3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
COMPOUND
468	pdb_id	contact mol		homologue
	pdb_id	a³	description	a⁴	identity[%]⁵	Ncon⁶	description
	1n26[6]	D	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms]..	A	100.0 /100.0	5 /5	IL6A_HUMAN IL-6 Receptor alpha chain
	1n26[6]	E	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms]..	A	100.0 /100.0	3 /3	IL6A_HUMAN IL-6 Receptor alpha chain
	1n26[1]	E	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms]..	A	100.0 /100.0	3 /3	IL6A_HUMAN IL-6 Receptor alpha chain
	5fuc[2]	G	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms]..	C	100.0 /99.0	3 /3	D6R9R8_HUMAN IL6RA_HUMAN INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA, INTERLEUKIN-..
	6o4p[7]	E	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms]..	A	50.0 /35.0	4 /4	I11RA_HUMAN Interleukin-11 receptor subunit alpha
	8d74[2]	P	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms]..	C	0.0 /34.7	1 /1	CNTFR_HUMAN Ciliary neurotrophic factor receptor subunit alpha..
	8d82[2]	S	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms]..	A	100.0 /100.0	3 /3	IL6RA_HUMAN Soluble interleukin-6 receptor subunit alpha
	8iow[1]	F	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms]..	A	100.0 /100.0	3 /3	IL6RA_HUMAN Interleukin-6 receptor subunit alpha
	1n26[2]	H	CYS CYSTEINE[7 atoms]	A	100.0 /100.0	5 /5	IL6A_HUMAN IL-6 Receptor alpha chain
	7dc8[2]	H	ATP ADENOSINE-5'-TRIPHOSPHATE[31 atoms]	C	100.0 /99.5	1 /1	IL6RA_HUMAN Interleukin-6 receptor subunit alpha
	3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
OTHERPOLY
468	pdb_id	contact mol		homologue
	pdb_id	a³	description	a⁴	identity[%]⁵	Ncon⁶	description
	1n26[2]	B	2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-al..	A	100.0 /100.0	9 /9	IL6A_HUMAN IL-6 Receptor alpha chain
	8dps[4]	H	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet..	C	0.0 /33.9	3 /3	I11RA_HUMAN Interleukin-11 receptor subunit alpha
	8dpu[6]	T	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-bet..	C	16.7 /35.3	6 /6	I11RA_HUMAN Interleukin-11 receptor subunit alpha
	6o4p[1]	C	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(..	A	0.0 /35.0	5 /5	I11RA_HUMAN Interleukin-11 receptor subunit alpha
	1n26[2]	C	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..	A	100.0 /100.0	5 /5	IL6A_HUMAN IL-6 Receptor alpha chain
	6o4p[1]	D	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..	B	0.0 /35.4	4 /4	I11RA_HUMAN Interleukin-11 receptor subunit alpha
	8d74[5]	F	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..	C	40.0 /34.7	5 /5	CNTFR_HUMAN Ciliary neurotrophic factor receptor subunit alpha..
	8d7e[3]	H	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..	A	50.0 /33.9	2 /4	CNTFR_HUMAN Ciliary neurotrophic factor receptor subunit alpha..
	8d7e[3]	I	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..	A	0.0 /33.9	2 /2	CNTFR_HUMAN Ciliary neurotrophic factor receptor subunit alpha..
	8d82[2]	G	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..	A	100.0 /100.0	1 /1	IL6RA_HUMAN Soluble interleukin-6 receptor subunit alpha
	8qy4[2]	I	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..	E	40.0 /31.7	5 /5	I11RA_HUMAN Interleukin-11 receptor subunit alpha
	8qy4[2]	J	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-a..	E	0.0 /31.7	5 /5	I11RA_HUMAN Interleukin-11 receptor subunit alpha
	1f45[1]	C	alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-be..	A	0.0 /30.4	3 /7	I12B_HUMAN INTERLEUKIN-12 BETA CHAIN
	3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
HOMO
468	pdb_id	contact mol		homologue
	pdb_id	a³	description	a⁴	identity[%]⁵	Ncon⁶	description
	1n26[1]	A	IL6A_HUMAN IL-6 Receptor alpha chain[299 aa]	A	100.0 /100.0	11 /11	IL6A_HUMAN IL-6 Receptor alpha chain
	1n26[1]	A	IL6A_HUMAN IL-6 Receptor alpha chain[299 aa]	A	100.0 /100.0	15 /15	IL6A_HUMAN IL-6 Receptor alpha chain
	8iow[1]	B	IL6RA_HUMAN Interleukin-6 receptor subunit alpha[14 aa]	A	100.0 /100.0	8 /8	IL6RA_HUMAN Interleukin-6 receptor subunit alpha
	1bqu[1]	B	IL6RB_HUMAN PROTEIN (GP130)[215 aa]	A	33.3 /30.2	9 /9	IL6RB_HUMAN PROTEIN (GP130)
	3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
PRECIPITANT
468	pdb_id	contact mol		homologue
	pdb_id	a³	description	a⁴	identity[%]⁵	Ncon⁶	description
	1bqu[2]	C	SO4 SULFATE ION[5 atoms]	A	0.0 /30.2	4 /4	IL6RB_HUMAN PROTEIN (GP130)
	1bqu[8]	E	SO4 SULFATE ION[5 atoms]	A	100.0 /30.2	2 /2	IL6RB_HUMAN PROTEIN (GP130)
	1n26[2]	F	SO4 SULFATE ION[5 atoms]	A	100.0 /100.0	3 /3	IL6A_HUMAN IL-6 Receptor alpha chain
	1n26[2]	G	SO4 SULFATE ION[5 atoms]	A	100.0 /100.0	3 /3	IL6A_HUMAN IL-6 Receptor alpha chain
	6o4p[1]	I	SO4 SULFATE ION[5 atoms]	A	0.0 /35.0	1 /3	I11RA_HUMAN Interleukin-11 receptor subunit alpha
	6o4p[2]	J	SO4 SULFATE ION[5 atoms]	A	33.3 /35.0	3 /3	I11RA_HUMAN Interleukin-11 receptor subunit alpha
	6o4p[1]	L	SO4 SULFATE ION[5 atoms]	B	0.0 /35.4	2 /2	I11RA_HUMAN Interleukin-11 receptor subunit alpha
	6o4p[1]	M	SO4 SULFATE ION[5 atoms]	B	0.0 /35.4	3 /3	I11RA_HUMAN Interleukin-11 receptor subunit alpha
	6o4p[1]	P	SO4 SULFATE ION[5 atoms]	B	0.0 /35.4	1 /1	I11RA_HUMAN Interleukin-11 receptor subunit alpha
	7dc8[2]	K	SO4 SULFATE ION[5 atoms]	C	100.0 /99.5	3 /3	IL6RA_HUMAN Interleukin-6 receptor subunit alpha
	1bqu[1]	F	GOL GLYCEROL[6 atoms]	A	50.0 /30.2	6 /6	IL6RB_HUMAN PROTEIN (GP130)
	1bqu[1]	G	GOL GLYCEROL[6 atoms]	A	25.0 /30.2	8 /8	IL6RB_HUMAN PROTEIN (GP130)
	3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

Contact Molecules for Homologous Proteins

Summary Bars[30 %]

UniProt Feature Tables [P08887(IL6RA_HUMAN)]