HOMCOS(prot_sch_conbars.cgi):

		Contact Molecules for Homologous Proteins
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PID

QueryLength

Homolgous Sequence in PDB

UniProt Query

TITLE

29280

794

P09958(FURIN_HUMAN)

RecName: Full=Furin ; EC=3.4.21.75 ;AltName: Full=Dibasic-processing enzyme;AltName: Full=Paired basic amino acid residue-cleaving enzyme; Short=PACE;Flags: Precursor;

QUERYSEQ

MELRPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQIFGDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVS
ILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREH
DSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKC
IIDILTEPKDIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTAPEGLPVPPESSGCKTLTSSQACVVCE
EGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQGPALTDCLSCPSHASLDPVEQTCSRQSQSSRESPPQQQPPRLPPEVEAGQRLRAGLLPSHLPEVVAGLSCAFIVLVFVTVFLVLQLRSGFSFRGVKVY
TMDRGLISYKGLPPEAWQEECPSDSEEDEGRGERTAFIKDQSAL

[BLAST file for PDB] (plain) (bar) (multiple alignment) [BLAST for UniProt: (plain) (bar) (multiple alignment) (PSSM file) ]

UniProt Feature Tables [P09958(FURIN_HUMAN)]

794
	region	name	description
	1-26	SIGNAL
	27-107	PROPEP	/note="Inhibition peptide" /id="PRO_0000027028"
	108-794	CHAIN	/note="Furin" /id="PRO_0000027029"
	108-715	TOPO_DOM	/note="Lumenal"
	716-738	TRANSMEM	/note="Helical"
	739-794	TOPO_DOM	/note="Cytoplasmic"
	121-435	DOMAIN	/note="Peptidase S8"
	444-576	DOMAIN	/note="P/Homo B"
	577-620	REPEAT	/note="FU 1"
	638-681	REPEAT	/note="FU 2"
	162-183	REGION	/note="Disordered"
	673-696	REGION	/note="Disordered"
	759-762	REGION	/note="Cell surface signal"
	767-794	REGION	/note="Disordered"
	673-687	COMPBIAS	/note="Polar residues"
	153-153	ACT_SITE	/note="Charge relay system"
	194-194	ACT_SITE	/note="Charge relay system"
	368-368	ACT_SITE	/note="Charge relay system"
	115-115	BINDING	/ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="1" ECO:0000269\|PubMed:25974265, ECO:0007744\|PDB:4OMC, ECO:0007744\|PDB:4OMD, ECO:0007744\|PDB:4RYD"
	154-154	BINDING	/ligand="substrate" ECO:0000305\|PubMed:25974265, ECO:0007744\|PDB:4OMC, ECO:0007744\|PDB:4OMD, ECO:0007744\|PDB:4RYD"
	162-162	BINDING	/ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="1" ECO:0000269\|PubMed:25974265, ECO:0007744\|PDB:4OMC, ECO:0007744\|PDB:4OMD, ECO:0007744\|PDB:4RYD"
	174-174	BINDING	/ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="2" ECO:0000269\|PubMed:25974265, ECO:0007744\|PDB:4OMC, ECO:0007744\|PDB:4OMD, ECO:0007744\|PDB:4RYD"
	179-179	BINDING	/ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="2" ECO:0000269\|PubMed:25974265, ECO:0007744\|PDB:4OMC, ECO:0007744\|PDB:4OMD, ECO:0007744\|PDB:4RYD"
	181-181	BINDING	/ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="2" ECO:0000269\|PubMed:25974265, ECO:0007744\|PDB:4OMC, ECO:0007744\|PDB:4OMD, ECO:0007744\|PDB:4RYD"
	191-192	BINDING	/ligand="substrate" ECO:0000305\|PubMed:25974265, ECO:0007744\|PDB:4OMC, ECO:0007744\|PDB:4OMD, ECO:0007744\|PDB:4RYD"
	205-205	BINDING	/ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="1" ECO:0000269\|PubMed:25974265, ECO:0007744\|PDB:4OMC, ECO:0007744\|PDB:4OMD, ECO:0007744\|PDB:4RYD"
	208-208	BINDING	/ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="1" ECO:0000269\|PubMed:25974265, ECO:0007744\|PDB:4OMC, ECO:0007744\|PDB:4OMD, ECO:0007744\|PDB:4RYD"
	210-210	BINDING	/ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="1" ECO:0000269\|PubMed:25974265, ECO:0007744\|PDB:4OMC, ECO:0007744\|PDB:4OMD, ECO:0007744\|PDB:4RYD"
	212-212	BINDING	/ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="1" ECO:0000269\|PubMed:25974265, ECO:0007744\|PDB:4OMC, ECO:0007744\|PDB:4OMD, ECO:0007744\|PDB:4RYD"
	236-236	BINDING	/ligand="substrate" ECO:0000305\|PubMed:25974265, ECO:0007744\|PDB:4OMC, ECO:0007744\|PDB:4OMD, ECO:0007744\|PDB:4RYD"
	253-258	BINDING	/ligand="substrate" ECO:0000305\|PubMed:25974265, ECO:0007744\|PDB:4OMC, ECO:0007744\|PDB:4OMD, ECO:0007744\|PDB:4RYD"
	258-258	BINDING	/ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="3" ECO:0000269\|PubMed:25974265, ECO:0007744\|PDB:4OMC, ECO:0007744\|PDB:4OMD, ECO:0007744\|PDB:4RYD"
	264-264	BINDING	/ligand="substrate" ECO:0000305\|PubMed:25974265, ECO:0007744\|PDB:4OMC, ECO:0007744\|PDB:4OMD, ECO:0007744\|PDB:4RYD"
	292-295	BINDING	/ligand="substrate" ECO:0000305\|PubMed:25974265, ECO:0007744\|PDB:4OMC, ECO:0007744\|PDB:4OMD, ECO:0007744\|PDB:4RYD"
	301-301	BINDING	/ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="3" ECO:0000269\|PubMed:25974265, ECO:0007744\|PDB:4OMC, ECO:0007744\|PDB:4OMD, ECO:0007744\|PDB:4RYD"
	306-306	BINDING	/ligand="substrate" ECO:0000305\|PubMed:25974265, ECO:0007744\|PDB:4OMC, ECO:0007744\|PDB:4OMD, ECO:0007744\|PDB:4RYD"
	308-308	BINDING	/ligand="substrate" ECO:0000305\|PubMed:25974265, ECO:0007744\|PDB:4OMC, ECO:0007744\|PDB:4OMD, ECO:0007744\|PDB:4RYD"
	331-331	BINDING	/ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="3" ECO:0000269\|PubMed:25974265, ECO:0007744\|PDB:4OMC, ECO:0007744\|PDB:4OMD, ECO:0007744\|PDB:4RYD"
	368-368	BINDING	/ligand="substrate" ECO:0000305\|PubMed:25974265, ECO:0007744\|PDB:4OMC, ECO:0007744\|PDB:4OMD, ECO:0007744\|PDB:4RYD"
	1-794	DISORDER	predicted by DISOPRED

MONOMER

794

pdb_id a¹ identity[%]² description

4omd A 100.0 FURIN_HUMAN Furin

6a8y A 100.0 FURIN_HUMAN YR26_SDS

1.a¹:asym_id for the homologue. 2.identity[%]²:sequence identity between the query and the homologue.

HETERO

794 pdb_id contact mol homologue

a³ description a⁴ identity[%]⁵ Ncon⁶ description

4omc[12] G meta-guanidinomethyl-phenylacetyl-Arg-Val-Arg-(ami.. A 100.0
/100.0 27
/27 FURIN_HUMAN Furin

4ryd[6] G para-guanidinomethyl-phenylacetyl-Arg-(3-methylval.. A 100.0
/100.0 28
/28 FURIN_HUMAN Furin

6hlb[1] B PHE-(ALN)-ARG-ARG-ARG-ARG-SLL-ARG-00S[7 aa] A 100.0
/100.0 27
/27 FURIN_HUMAN Furin

3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

COMPOUND

794 pdb_id contact mol homologue

a³ description a⁴ identity[%]⁵ Ncon⁶ description

7o1y[1] B UYQ
[[(2E)-2-[[4-[(E)-[[azaniumylidene(azanyl)methyl]h.. A 100.0
/100.0 11
/11 FURIN_HUMAN Furin

7o1y[1] C UYQ
[[(2E)-2-[[4-[(E)-[[azaniumylidene(azanyl)methyl]h.. A 100.0
/100.0 9
/9 FURIN_HUMAN Furin

7o1y[1] D UYQ
[[(2E)-2-[[4-[(E)-[[azaniumylidene(azanyl)methyl]h.. A 100.0
/100.0 5
/5 FURIN_HUMAN Furin

7o1y[3] S NAG
2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms].. A 100.0
/100.0 2
/2 FURIN_HUMAN Furin

7o20[1] B UYT
[azanyl-[(2E)-2-(1-phenylethylidene)hydrazinyl]met.. A 100.0
/100.0 7
/7 FURIN_HUMAN Furin

7o20[1] C UYT
[azanyl-[(2E)-2-(1-phenylethylidene)hydrazinyl]met.. A 100.0
/100.0 8
/8 FURIN_HUMAN Furin

7o20[1] D UYT
[azanyl-[(2E)-2-(1-phenylethylidene)hydrazinyl]met.. A 100.0
/100.0 5
/5 FURIN_HUMAN Furin

7o22[1] M UYW
[azanyl-[(2E)-2-[[2-[(4-chlorophenyl)methoxy]pheny.. A 100.0
/100.0 14
/14 FURIN_HUMAN Furin

3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

METAL

794 pdb_id contact mol homologue

a³ description a⁴ identity[%]⁵ Ncon⁶ description

4omc[22] Q CA
CALCIUM ION[1 atoms] A 100.0
/100.0 6
/6 FURIN_HUMAN Furin

4omc[22] R CA
CALCIUM ION[1 atoms] A 100.0
/100.0 3
/3 FURIN_HUMAN Furin

4omc[22] S CA
CALCIUM ION[1 atoms] A 100.0
/100.0 3
/3 FURIN_HUMAN Furin

4omc[22] T NA
SODIUM ION[1 atoms] A 100.0
/100.0 5
/5 FURIN_HUMAN Furin

6hlb[1] G NA
SODIUM ION[1 atoms] A 100.0
/100.0 2
/2 FURIN_HUMAN Furin

6hlb[1] H NA
SODIUM ION[1 atoms] A 100.0
/100.0 3
/3 FURIN_HUMAN Furin

7o1y[3] I NA
SODIUM ION[1 atoms] A 100.0
/100.0 1
/1 FURIN_HUMAN Furin

6hlb[4] I CL
CHLORIDE ION[1 atoms] A 100.0
/100.0 3
/3 FURIN_HUMAN Furin

3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

PRECIPITANT

794 pdb_id contact mol homologue

a³ description a⁴ identity[%]⁵ Ncon⁶ description

4omc[12] M FMT
FORMIC ACID[3 atoms] A 100.0
/100.0 4
/4 FURIN_HUMAN Furin

4omc[6] N FMT
FORMIC ACID[3 atoms] A 100.0
/100.0 5
/5 FURIN_HUMAN Furin

4omc[36] O FMT
FORMIC ACID[3 atoms] A 100.0
/100.0 3
/3 FURIN_HUMAN Furin

6hlb[1] J PO4
PHOSPHATE ION[5 atoms] A 100.0
/100.0 5
/5 FURIN_HUMAN Furin

6hlb[1] K PO4
PHOSPHATE ION[5 atoms] A 100.0
/100.0 2
/2 FURIN_HUMAN Furin

6hlb[5] L DMS
DIMETHYL SULFOXIDE[4 atoms] A 100.0
/100.0 5
/5 FURIN_HUMAN Furin

7o1y[1] L DMS
DIMETHYL SULFOXIDE[4 atoms] A 100.0
/100.0 3
/3 FURIN_HUMAN Furin

7o1y[4] M DMS
DIMETHYL SULFOXIDE[4 atoms] A 100.0
/100.0 2
/2 FURIN_HUMAN Furin

7o1y[2] N DMS
DIMETHYL SULFOXIDE[4 atoms] A 100.0
/100.0 5
/5 FURIN_HUMAN Furin

7o1y[3] O DMS
DIMETHYL SULFOXIDE[4 atoms] A 100.0
/100.0 3
/3 FURIN_HUMAN Furin

7o1y[3] P DMS
DIMETHYL SULFOXIDE[4 atoms] A 100.0
/100.0 4
/4 FURIN_HUMAN Furin

7o1y[1] Q DMS
DIMETHYL SULFOXIDE[4 atoms] A 100.0
/100.0 2
/2 FURIN_HUMAN Furin

3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

MONOMER
794
	pdb_id	a¹	identity[%]²	description
	4omd	A	100.0	FURIN_HUMAN Furin
	6a8y	A	100.0	FURIN_HUMAN YR26_SDS
	1.a¹:asym_id for the homologue. 2.identity[%]²:sequence identity between the query and the homologue.

HETERO
794	pdb_id	contact mol		homologue
	pdb_id	a³	description	a⁴	identity[%]⁵	Ncon⁶	description
	4omc[12]	G	meta-guanidinomethyl-phenylacetyl-Arg-Val-Arg-(ami..	A	100.0 /100.0	27 /27	FURIN_HUMAN Furin
	4ryd[6]	G	para-guanidinomethyl-phenylacetyl-Arg-(3-methylval..	A	100.0 /100.0	28 /28	FURIN_HUMAN Furin
	6hlb[1]	B	PHE-(ALN)-ARG-ARG-ARG-ARG-SLL-ARG-00S[7 aa]	A	100.0 /100.0	27 /27	FURIN_HUMAN Furin
	3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
COMPOUND
794	pdb_id	contact mol		homologue
	pdb_id	a³	description	a⁴	identity[%]⁵	Ncon⁶	description
	7o1y[1]	B	UYQ [[(2E)-2-[[4-[(E)-[[azaniumylidene(azanyl)methyl]h..	A	100.0 /100.0	11 /11	FURIN_HUMAN Furin
	7o1y[1]	C	UYQ [[(2E)-2-[[4-[(E)-[[azaniumylidene(azanyl)methyl]h..	A	100.0 /100.0	9 /9	FURIN_HUMAN Furin
	7o1y[1]	D	UYQ [[(2E)-2-[[4-[(E)-[[azaniumylidene(azanyl)methyl]h..	A	100.0 /100.0	5 /5	FURIN_HUMAN Furin
	7o1y[3]	S	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose[14 atoms]..	A	100.0 /100.0	2 /2	FURIN_HUMAN Furin
	7o20[1]	B	UYT [azanyl-[(2E)-2-(1-phenylethylidene)hydrazinyl]met..	A	100.0 /100.0	7 /7	FURIN_HUMAN Furin
	7o20[1]	C	UYT [azanyl-[(2E)-2-(1-phenylethylidene)hydrazinyl]met..	A	100.0 /100.0	8 /8	FURIN_HUMAN Furin
	7o20[1]	D	UYT [azanyl-[(2E)-2-(1-phenylethylidene)hydrazinyl]met..	A	100.0 /100.0	5 /5	FURIN_HUMAN Furin
	7o22[1]	M	UYW [azanyl-[(2E)-2-[[2-[(4-chlorophenyl)methoxy]pheny..	A	100.0 /100.0	14 /14	FURIN_HUMAN Furin
	3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
METAL
794	pdb_id	contact mol		homologue
	pdb_id	a³	description	a⁴	identity[%]⁵	Ncon⁶	description
	4omc[22]	Q	CA CALCIUM ION[1 atoms]	A	100.0 /100.0	6 /6	FURIN_HUMAN Furin
	4omc[22]	R	CA CALCIUM ION[1 atoms]	A	100.0 /100.0	3 /3	FURIN_HUMAN Furin
	4omc[22]	S	CA CALCIUM ION[1 atoms]	A	100.0 /100.0	3 /3	FURIN_HUMAN Furin
	4omc[22]	T	NA SODIUM ION[1 atoms]	A	100.0 /100.0	5 /5	FURIN_HUMAN Furin
	6hlb[1]	G	NA SODIUM ION[1 atoms]	A	100.0 /100.0	2 /2	FURIN_HUMAN Furin
	6hlb[1]	H	NA SODIUM ION[1 atoms]	A	100.0 /100.0	3 /3	FURIN_HUMAN Furin
	7o1y[3]	I	NA SODIUM ION[1 atoms]	A	100.0 /100.0	1 /1	FURIN_HUMAN Furin
	6hlb[4]	I	CL CHLORIDE ION[1 atoms]	A	100.0 /100.0	3 /3	FURIN_HUMAN Furin
	3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
PRECIPITANT
794	pdb_id	contact mol		homologue
	pdb_id	a³	description	a⁴	identity[%]⁵	Ncon⁶	description
	4omc[12]	M	FMT FORMIC ACID[3 atoms]	A	100.0 /100.0	4 /4	FURIN_HUMAN Furin
	4omc[6]	N	FMT FORMIC ACID[3 atoms]	A	100.0 /100.0	5 /5	FURIN_HUMAN Furin
	4omc[36]	O	FMT FORMIC ACID[3 atoms]	A	100.0 /100.0	3 /3	FURIN_HUMAN Furin
	6hlb[1]	J	PO4 PHOSPHATE ION[5 atoms]	A	100.0 /100.0	5 /5	FURIN_HUMAN Furin
	6hlb[1]	K	PO4 PHOSPHATE ION[5 atoms]	A	100.0 /100.0	2 /2	FURIN_HUMAN Furin
	6hlb[5]	L	DMS DIMETHYL SULFOXIDE[4 atoms]	A	100.0 /100.0	5 /5	FURIN_HUMAN Furin
	7o1y[1]	L	DMS DIMETHYL SULFOXIDE[4 atoms]	A	100.0 /100.0	3 /3	FURIN_HUMAN Furin
	7o1y[4]	M	DMS DIMETHYL SULFOXIDE[4 atoms]	A	100.0 /100.0	2 /2	FURIN_HUMAN Furin
	7o1y[2]	N	DMS DIMETHYL SULFOXIDE[4 atoms]	A	100.0 /100.0	5 /5	FURIN_HUMAN Furin
	7o1y[3]	O	DMS DIMETHYL SULFOXIDE[4 atoms]	A	100.0 /100.0	3 /3	FURIN_HUMAN Furin
	7o1y[3]	P	DMS DIMETHYL SULFOXIDE[4 atoms]	A	100.0 /100.0	4 /4	FURIN_HUMAN Furin
	7o1y[1]	Q	DMS DIMETHYL SULFOXIDE[4 atoms]	A	100.0 /100.0	2 /2	FURIN_HUMAN Furin
	3.a³:asym_id for the contact molecule. 4.a⁴:asym_id for the template homologue. 5.identity[%]⁵:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon⁶:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.

Contact Molecules for Homologous Proteins

Summary Bars[100 %]

UniProt Feature Tables [P09958(FURIN_HUMAN)]