Contact Molecules for Homologous Proteins


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PID QueryLength Homolgous Sequence in PDB UniProt Query TITLE
11352 740 48 Q92499(DDX1_HUMAN) RecName: Full=ATP-dependent RNA helicase DDX1; EC=3.6.4.13 ;AltName: Full=DEAD box protein 1;AltName: Full=DEAD box protein retinoblastoma; Short=DBP-RB;
QUERYSEQ
MAAFSEMGVMPEIAQAVEEMDWLLPTDIQAESIPLILGGGDVLMAAETGSGKTGAFSIPVIQIVYETLKDQQEGKKGKTTIKTGASVLNKWQMNPYDRGSAFAIGSDGLCCQSREVKEWHGCRATKGLMKGKHYYEVSCHDQGLCRVGWS
TMQASLDLGTDKFGFGFGGTGKKSHNKQFDNYGEEFTMHDTIGCYLDIDKGHVKFSKNGKDLGLAFEIPPHMKNQALFPACVLKNAELKFNFGEEEFKFPPKDGFVALSKAPDGYIVKSQHSGNAQVTQTKFLPNAPKALIVEPSRELAE
QTLNNIKQFKKYIDNPKLRELLIIGGVAARDQLSVLENGVDIVVGTPGRLDDLVSTGKLNLSQVRFLVLDEADGLLSQGYSDFINRMHNQIPQVTSDGKRLQVIVCSATLHSFDVKKLSEKIMHFPTWVDLKGEDSVPDTVHHVVVPVNP
KTDRLWERLGKSHIRTDDVHAKDNTRPGANSPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKIDCDNLEQYFIQQGGGPDKKGHQFSCVCLHGDRKPHERKQNLERFKKGDVRFLICTDVAARGIDIHGVPYVINVTLPDEKQNYV
HRIGRVGRAERMGLAISLVATEKEKVWYHVCSSRGKGCYNTRLKEDGGCTIWYNEMQLLSEIEEHLNCTISQVEPDIKVPVDEFDGKVTYGQKRAAGGGSYKGHVDILAPTVQELAALEKEAQTSFLHLGYLPNQLFRTF
[BLAST file for PDB] (plain) (bar) (multiple alignment) [BLAST for UniProt: (plain) (bar) (multiple alignment) (PSSM file) ]

UniProt Feature Tables [Q92499(DDX1_HUMAN)]

740
region name description
1-740 CHAIN /note="ATP-dependent RNA helicase DDX1" /id="PRO_0000054986"
2-428 DOMAIN /note="Helicase ATP-binding"
70-247 DOMAIN /note="B30.2/SPRY"
493-681 DOMAIN /note="Helicase C-terminal"
1-525 REGION /note="Necessary for interaction with RELA"
1-448 REGION /note="Interaction with dsRNA"
1-295 REGION /note="Necessary for interaction with HNRNPK"
525-740 REGION /note="Necessary for interaction with HNRNPK"
536-631 REGION /note="Necessary for interaction with replicase polyprotein 1ab nsp14 of IBV"
46-53 BINDING /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616"
1-718 DISORDER predicted by DISOPRED

MONOMER
740
pdb_id a1 identity[%]2 description
8tbx A 100.0 DDX1_HUMAN DDX1_HUMAN ATP-dependent RNA helicase DDX1
4xw3 B 100.0 A3RJH1_HUMAN ATP-dependent RNA helicase DDX1
1.a1:asym_id for the homologue. 2.identity[%]2:sequence identity between the query and the homologue.
HETERO
740 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
3peu[2] B GLE1_YEAST Nucleoporin GLE1[295 aa] A 36.4
/46.0
11
/24
DBP5_YEAST ATP-dependent RNA helicase DBP5
3peu[2] B GLE1_YEAST Nucleoporin GLE1[295 aa] A 40.0
/46.0
10
/14
DBP5_YEAST ATP-dependent RNA helicase DBP5
6elz[2] FA CIC1_YEAST Proteasome-interacting protein CIC1[257 aa] HA 0.0
/44.3
1
/15
HAS1_YEAST ATP-dependent RNA helicase HAS1
8eti[2] GA RL36B_SCHPO 60S ribosomal protein L36-B[85 aa] J 0.0
/41.9
3
/3
HAS1_SCHPO ATP-dependent RNA helicase has1
6yvh[1] A CWC22_HUMAN Pre-mRNA-splicing factor CWC22 homolog[274 aa] F 42.9
/40.6
7
/23
IF4A3_HUMAN Eukaryotic initiation factor 4A-III
6yvh[1] E CWC22_HUMAN Pre-mRNA-splicing factor CWC22 homolog[272 aa] F 50.0
/40.6
12
/12
IF4A3_HUMAN Eukaryotic initiation factor 4A-III
5nt7[2] B OSKA_DROME Maternal effect protein oskar[92 aa] A 34.8
/40.2
23
/23
VASA1_DROME ATP-dependent RNA helicase vasa, isoform A
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
NUCLEOTIDE
740 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
6elz[1] A 25S ribosomal RNA HA 0.0
/44.3
1
/5
HAS1_YEAST ATP-dependent RNA helicase HAS1
8eti[1] A RNA (1564-MER) J 20.0
/41.9
5
/6
HAS1_SCHPO ATP-dependent RNA helicase has1
8eup[1] A RNA (1422-MER) J 28.6
/41.8
7
/10
S6CCW7_SCHPM RNA helicase
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
COMPOUND
740 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
8tbx[1] B ADP
ADENOSINE-5'-DIPHOSPHATE[27 atoms]
A 100.0
/100.0
15
/15
DDX1_HUMAN DDX1_HUMAN ATP-dependent RNA helicase DDX1
5gju[1] B AMP
ADENOSINE MONOPHOSPHATE[23 atoms]
A 72.7
/40.4
11
/11
DEAD_ECOLI ATP-dependent RNA helicase DeaD
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
METAL
740 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
1fuk[1] B ZN
ZINC ION[1 atoms]
A 33.3
/42.6
3
/3
IF4A_YEAST EUKARYOTIC INITIATION FACTOR 4A
2rb4[1] F ZN
ZINC ION[1 atoms]
A 50.0
/41.7
2
/2
DDX25_HUMAN ATP-dependent RNA helicase DDX25
8tbx[1] D ZN
ZINC ION[1 atoms]
A 100.0
/100.0
4
/4
DDX1_HUMAN DDX1_HUMAN ATP-dependent RNA helicase DDX1
8tbx[1] C MG
MAGNESIUM ION[1 atoms]
A 100.0
/100.0
3
/3
DDX1_HUMAN DDX1_HUMAN ATP-dependent RNA helicase DDX1
2rb4[1] C CL
CHLORIDE ION[1 atoms]
A 100.0
/41.7
1
/1
DDX25_HUMAN ATP-dependent RNA helicase DDX25
2rb4[1] D CL
CHLORIDE ION[1 atoms]
A 50.0
/41.7
2
/2
DDX25_HUMAN ATP-dependent RNA helicase DDX25
3eaq[1] C CL
CHLORIDE ION[1 atoms]
A 100.0
/42.5
3
/3
Q72GF3_THET2 Heat resistant RNA dependent ATPase
3eaq[1] D CL
CHLORIDE ION[1 atoms]
B 0.0
/41.9
1
/3
Q72GF3_THET2 Heat resistant RNA dependent ATPase
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.
PRECIPITANT
740 pdb_id contact mol homologue
a3 description a4 identity[%]5 Ncon6 description
2rb4[2] E SO4
SULFATE ION[5 atoms]
A 0.0
/41.7
2
/2
DDX25_HUMAN ATP-dependent RNA helicase DDX25
3peu[4] C SO4
SULFATE ION[5 atoms]
A 100.0
/46.0
2
/2
DBP5_YEAST ATP-dependent RNA helicase DBP5
3peu[4] D GOL
GLYCEROL[6 atoms]
A 57.1
/46.0
7
/7
DBP5_YEAST ATP-dependent RNA helicase DBP5
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue.