Contact Molecules for Homologous Proteins | ||||
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PID | QueryLength | Homolgous Sequence in PDB | UniProt Query | TITLE |
29474 | 1170 | 23 | P20701(ITAL_HUMAN) | RecName: Full=Integrin alpha-L ;AltName: Full=CD11 antigen-like family member A;AltName: Full=Leukocyte adhesion glycoprotein LFA-1 alpha chain; Short=LFA-1A;AltName: Full=Leukocyte function-associated molecule 1 alpha chain;AltName: CD_antigen=CD11a;Flags: Precursor; |
QUERYSEQ |
MKDSCITVMAMALLSGFFFFAPASSYNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGAPGEGNSTGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTDGSILACDPGLSRTCDQNTYLSGLCYLFRQNLQGPMLQGRPGFQEC IKGNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKRKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLH KFASKPASEFVKILDTFEKLKDLFTELQKKIYVIEGTSKQDLTSFNMELSSSGISADLSRGHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNEPLTPEVRAGYLGYTVTWLPSRQKTSLLASGAPRYQHMGRVLLFQEPQGGGHWSQVQT IHGTQIGSYFGGELCGVDVDQDGETELLLIGAPLFYGEQRGGRVFIYQRRQLGFEEVSELQGDPGYPLGRFGEAITALTDINGDGLVDVAVGAPLEEQGAVYIFNGRHGGLSPQPSQRIEGTQVLSGIQWFGRSIHGVKDLEGDGLADVA VGAESQMIVLSSRPVVDMVTLMSFSPAEIPVHEVECSYSTSNKMKEGVNITICFQIKSLIPQFQGRLVANLTYTLQLDGHRTRRRGLFPGGRHELRRNIAVTTSMSCTDFSFHFPVCVQDLISPINVSLNFSLWEEEGTPRDQRAQGKDI PPILRPSLHSETWEIPFEKNCGEDKKCEANLRVSFSPARSRALRLTAFASLSVELSLSNLEEDAYWVQLDLHFPPGLSFRKVEMLKPHSQIPVSCEELPEESRLLSRALSCNVSSPIFKAGHSVALQMMFNTLVNSSWGDSVELHANVTC NNEDSDLLEDNSATTIIPILYPINILIQDQEDSTLYVSFTPKGPKIHQVKHMYQVRIQPSIHDHNIPTLEAVVGVPQPPSEGPITHQWSVQMEPPVPCHYEDLERLPDAAEPCLPGALFRCPVVFRQEILVQVIGTLELVGEIEASSMFS LCSSLSISFNSSKHFHLYGSNASLAQVVMKVDVVYEKQMLYLYVLSGIGGLLLLLLIFIVLYKVGFFKRNLKEKMEAGRGVPNGIPAEDSEQLASGQEAGDPGCLKPLHEKDSESGGGKD |
1170 | region | name | description |
1-25 | SIGNAL | ||
26-1170 | CHAIN | /note="Integrin alpha-L" /id="PRO_0000016292" | |
26-1090 | TOPO_DOM | /note="Extracellular" | |
1091-1111 | TRANSMEM | /note="Helical" | |
1112-1170 | TOPO_DOM | /note="Cytoplasmic" | |
31-82 | REPEAT | /note="FG-GAP 1" | |
83-141 | REPEAT | /note="FG-GAP 2" | |
156-327 | DOMAIN | /note="VWFA" | |
338-389 | REPEAT | /note="FG-GAP 3" | |
390-445 | REPEAT | /note="FG-GAP 4" | |
446-506 | REPEAT | /note="FG-GAP 5" | |
507-563 | REPEAT | /note="FG-GAP 6" | |
567-627 | REPEAT | /note="FG-GAP 7" | |
1128-1170 | REGION | /note="Disordered" | |
1154-1170 | COMPBIAS | /note="Basic and acidic residues" | |
468-468 | BINDING | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="1" | |
470-470 | BINDING | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="1" | |
472-472 | BINDING | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="1" | |
476-476 | BINDING | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="1" | |
530-530 | BINDING | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="2" | |
532-532 | BINDING | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="2" | |
534-534 | BINDING | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="2" | |
538-538 | BINDING | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="2" | |
590-590 | BINDING | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="3" | |
594-594 | BINDING | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="3" | |
598-598 | BINDING | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="3" | |
1-1170 | DISORDER | predicted by DISOPRED |
MONOMER | |||||||
1170 | |||||||
pdb_id | a1 | identity[%]2 | description | ||||
1rd4 | C | 100.0 | ITAL_HUMAN Integrin alpha-L | ||||
2m3e | A | 100.0 | ITAL_HUMAN Integrin alpha-L | ||||
1.a1:asym_id for the homologue. 2.identity[%]2:sequence identity between the query and the homologue. |
HETERO | |||||||
1170 | pdb_id | contact mol | homologue | ||||
a3 | description | a4 | identity[%]5 | Ncon6 | description | ||
3eoa[4] | A | Efalizumab Fab fragment, light chain[214 aa] | E | 100.0 /100.0 |
1 /1 |
ITAL_HUMAN Integrin alpha-L | |
3eoa[4] | C | Efalizumab Fab fragment, heavy chain[215 aa] | E | 100.0 /100.0 |
14 /14 |
ITAL_HUMAN Integrin alpha-L | |
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue. | |||||||
COMPOUND | |||||||
1170 | pdb_id | contact mol | homologue | ||||
a3 | description | a4 | identity[%]5 | Ncon6 | description | ||
1rd4[4] | E |
L08
1-ACETYL-4-(4-{4-[(2-ETHOXYPHENYL)THIO]-3-NITROPHE.. |
A | 100.0 /100.0 |
19 /19 |
ITAL_HUMAN Integrin alpha-L | |
2ica[1] | B |
2IC
5-[(5S,9R)-9-(4-CYANOPHENYL)-3-(3,5-DICHLOROPHENYL.. |
A | 100.0 /100.0 |
12 /12 |
ITAL_HUMAN Integrin alpha-L | |
2o7n[1] | B |
2O7
7A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-.. |
A | 100.0 /100.0 |
12 /12 |
ITAL_HUMAN Integrin alpha-L | |
3m6f[1] | B |
BJZ
6-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl.. |
A | 100.0 /100.0 |
15 /15 |
ITAL_HUMAN Integrin alpha-L | |
7kc5[2] | D |
BJZ
6-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl.. |
A | 100.0 /100.0 |
12 /12 |
ITAL_HUMAN Integrin alpha-L | |
7kc6[2] | C |
803
LOVASTATIN[29 atoms] |
A | 100.0 /100.0 |
9 /9 |
ITAL_HUMAN Integrin alpha-L | |
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue. | |||||||
METAL | |||||||
1170 | pdb_id | contact mol | homologue | ||||
a3 | description | a4 | identity[%]5 | Ncon6 | description | ||
1lfa[4] | C |
MN
MANGANESE (II) ION[1 atoms] |
A | 100.0 /100.0 |
3 /3 |
ITAL_HUMAN CD11A | |
1lfa[6] | D |
CL
CHLORIDE ION[1 atoms] |
A | 100.0 /100.0 |
3 /3 |
ITAL_HUMAN CD11A | |
1zoo[2] | C |
MG
MAGNESIUM ION[1 atoms] |
A | 100.0 /100.0 |
5 /5 |
ITAL_HUMAN LEUKOCYTE ADHESION GLYCOPROTEIN | |
7kc5[4] | C |
MG
MAGNESIUM ION[1 atoms] |
A | 100.0 /100.0 |
6 /6 |
ITAL_HUMAN Integrin alpha-L | |
3eob[2] | G |
ZN
ZINC ION[1 atoms] |
C | 100.0 /100.0 |
6 /6 |
ITAL_HUMAN Integrin alpha-L | |
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue. | |||||||
HOMO | |||||||
1170 | pdb_id | contact mol | homologue | ||||
a3 | description | a4 | identity[%]5 | Ncon6 | description | ||
1lfa[1] | B | ITAL_HUMAN CD11A[182 aa] | A | 100.0 /100.0 |
5 /5 |
ITAL_HUMAN CD11A | |
1lfa[1] | A | ITAL_HUMAN CD11A[183 aa] | B | 100.0 /100.0 |
7 /7 |
ITAL_HUMAN CD11A | |
1zoo[4] | B | ITAL_HUMAN LEUKOCYTE ADHESION GLYCOPROTEIN[183 aa] | A | 100.0 /100.0 |
20 /20 |
ITAL_HUMAN LEUKOCYTE ADHESION GLYCOPROTEIN | |
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue. | |||||||
PRECIPITANT | |||||||
1170 | pdb_id | contact mol | homologue | ||||
a3 | description | a4 | identity[%]5 | Ncon6 | description | ||
3m6f[1] | C |
NO3
NITRATE ION[4 atoms] |
A | 100.0 /100.0 |
3 /3 |
ITAL_HUMAN Integrin alpha-L | |
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue. |