Contact Molecules for Homologous Proteins | ||||
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PID | QueryLength | Homolgous Sequence in PDB | UniProt Query | TITLE |
3177230 | 1130 | 93 | P33076(C2TA_HUMAN) | RecName: Full=MHC class II transactivator ; Short=CIITA ; EC=2.3.1.- ; EC=2.7.11.1 ; |
QUERYSEQ |
MRCLAPRPAGSYLSEPQGSSQCATMELGPLEGGYLELLNSDADPLCLYHFYDQMDLAGEEEIELYSEPDTDTINCDQFSRLLCDMEGDEETREAYANIAELDQYVFQDSQLEGLSKDIFKHIGPDEVIGESMEMPAEVGQKSQKRPFPEE LPADLKHWKPAEPPTVVTGSLLVRPVSDCSTLPCLPLPALFNQEPASGQMRLEKTDQIPMPFSSSSLSCLNLPEGPIQFVPTISTLPHGLWQISEAGTGVSSIFIYHGEVPQASQVPPPSGFTVHGLPTSPDRPGSTSPFAPSATDLPSM PEPALTSRANMTEHKTSPTQCPAAGEVSNKLPKWPEPVEQFYRSLQDTYGAEPAGPDGILVEVDLVQARLERSSSKSLERELATPDWAERQLAQGGLAEVLLAAKEHRRPRETRVIAVLGKAGQGKSYWAGAVSRAWACGRLPQYDFVFS VPCHCLNRPGDAYGLQDLLFSLGPQPLVAADEVFSHILKRPDRVLLILDGFEELEAQDGFLHSTCGPAPAEPCSLRGLLAGLFQKKLLRGCTLLLTARPRGRLVQSLSKADALFELSGFSMEQAQAYVMRYFESSGMTEHQDRALTLLRD RPLLLSHSHSPTLCRAVCQLSEALLELGEDAKLPSTLTGLYVGLLGRAALDSPPGALAELAKLAWELGRRHQSTLQEDQFPSADVRTWAMAKGLVQHPPRAAESELAFPSFLLQCFLGALWLALSGEIKDKELPQYLALTPRKKRPYDNW LEGVPRFLAGLIFQPPARCLGALLGPSAAASVDRKQKVLARYLKRLQPGTLRARQLLELLHCAHEAEEAGIWQHVVQELPGRLSFLGTRLTPPDAHVLGKALEAAGQDFSLDLRSTGICPSGLGSLVGLSCVTRFRAALSDTVALWESLQ QHGETKLLQAAEEKFTIEPFKAKSLKDVEDLGKLVQTQRTRSSSEDTAGELPAVRDLKKLEFALGPVSGPQAFPKLVRILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLS LYNNCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRCPHVETLAMWTPTIPFSVQEHLQQQDSRISLR |
1130 | region | name | description |
1-1130 | CHAIN | /note="MHC class II transactivator" /id="PRO_0000089241" | |
414-724 | DOMAIN | /note="NACHT" | |
985-1008 | REPEAT | /note="LRR 1" | |
1016-1037 | REPEAT | /note="LRR 2" | |
1045-1066 | REPEAT | /note="LRR 3" | |
1073-1093 | REPEAT | /note="LRR 4" | |
94-132 | REGION | /note="Required for acetyltransferase activity" | |
269-303 | REGION | /note="Disordered" | |
280-294 | COMPBIAS | /note="Polar residues" | |
420-427 | BINDING | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" | |
1-1130 | DISORDER | predicted by DISOPRED |
MONOMER | |||||||
1130 | |||||||
pdb_id | a1 | identity[%]2 | description | ||||
7pzc | H | 31.5 | NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 | ||||
5irm | B | 34.5 | G1T469_RABIT Uncharacterized protein | ||||
8xi3 | C | 24.6 | NALP5_MOUSE NACHT, LRR and PYD domains-containing protein 5 | ||||
7wge | A | 32.7 | NLRP1_HUMAN NACHT, LRR and PYD domains-containing protein 1, N-terminus | ||||
1.a1:asym_id for the homologue. 2.identity[%]2:sequence identity between the query and the homologue. |
HETERO | |||||||
1130 | pdb_id | contact mol | homologue | ||||
a3 | description | a4 | identity[%]5 | Ncon6 | description | ||
7wge[1] | B | A0A2H1VFV3_SPOFR Thioredoxin[106 aa] | A | 28.6 /32.7 |
14 /14 |
NLRP1_HUMAN NACHT, LRR and PYD domains-containing protein 1, N.. | |
6npy[1] | B | E2AK2_HUMAN NEK7_HUMAN Protein kinase R,Serine/threonine-protein kinase N.. | A | 20.0 /32.4 |
5 /29 |
NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 | |
8sxn[2] | A | NEK7_HUMAN Serine/threonine-protein kinase Nek7[284 aa] | C | 21.4 /32.0 |
14 /44 |
NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 | |
8ej4[10] | K | NEK7_HUMAN Serine/threonine-protein kinase Nek7[261 aa] | A | 14.3 /31.7 |
7 /13 |
NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 | |
8h93[6] | B | TLE6_MOUSE Transducin-like enhancer protein 6[367 aa] | A | 18.9 /24.6 |
37 /52 |
NALP5_MOUSE NACHT, LRR and PYD domains-containing protein 5 | |
8h93[6] | C | OOEP_MOUSE Oocyte-expressed protein homolog[89 aa] | A | 15.8 /24.6 |
19 /22 |
NALP5_MOUSE NACHT, LRR and PYD domains-containing protein 5 | |
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue. | |||||||
COMPOUND | |||||||
1130 | pdb_id | contact mol | homologue | ||||
a3 | description | a4 | identity[%]5 | Ncon6 | description | ||
7vtp[6] | H |
7YN
1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-.. |
A | 46.2 /32.5 |
13 /13 |
NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 | |
7vtq[12] | N |
7YN
1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-.. |
A | 58.3 /33.0 |
12 /12 |
NLRP3_MOUSE NACHT, LRR and PYD domains-containing protein 3 | |
8swk[8] | G |
7YN
1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-.. |
A | 30.8 /32.0 |
13 /13 |
NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 | |
8swk[8] | H |
ATP
ADENOSINE-5'-TRIPHOSPHATE[31 atoms] |
A | 50.0 /32.0 |
12 /16 |
NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 | |
5irl[4] | B |
ADP
ADENOSINE-5'-DIPHOSPHATE[27 atoms] |
A | 57.1 /33.9 |
14 /17 |
G1T469_RABIT Uncharacterized protein | |
6npy[11] | C |
ADP
ADENOSINE-5'-DIPHOSPHATE[27 atoms] |
A | 44.4 /32.4 |
9 /12 |
NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 | |
7alv[4] | C |
ADP
ADENOSINE-5'-DIPHOSPHATE[27 atoms] |
A | 53.8 /31.7 |
13 /18 |
NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 | |
7vtp[6] | G |
ADP
ADENOSINE-5'-DIPHOSPHATE[27 atoms] |
A | 50.0 /32.5 |
12 /16 |
NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 | |
7vtq[12] | M |
ADP
ADENOSINE-5'-DIPHOSPHATE[27 atoms] |
A | 42.9 /33.0 |
14 /18 |
NLRP3_MOUSE NACHT, LRR and PYD domains-containing protein 3 | |
7wbt[2] | C |
ADP
ADENOSINE-5'-DIPHOSPHATE[27 atoms] |
A | 50.0 /33.1 |
12 /19 |
NLRP9_BOVIN NACHT, LRR and PYD domains-containing protein 9 | |
7wbu[2] | B |
ADP
ADENOSINE-5'-DIPHOSPHATE[27 atoms] |
A | 55.6 /33.1 |
9 /15 |
NLRP9_BOVIN NACHT, LRR and PYD domains-containing protein 9 | |
7zgu[6] | G |
ADP
ADENOSINE-5'-DIPHOSPHATE[27 atoms] |
A | 63.6 /32.4 |
11 /15 |
NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 | |
8etr[1] | D |
WTN
(6S,8R)-N-[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)c.. |
A | 50.0 /31.8 |
14 /14 |
NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 | |
8zem[1] | B |
A1D79
1-[5-[2,3-bis(chloranyl)phenyl]-2,3-dihydro-1~{H}-.. |
A | 53.3 /31.8 |
15 /18 |
NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 | |
8wsm[1] | D |
XE3
2-[[2-methyl-5-(trifluoromethyl)phenyl]amino]-~{N}.. |
A | 50.0 /31.8 |
16 /16 |
NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 | |
7alv[1] | B |
RM5
1-[4-chloranyl-2,6-di(propan-2-yl)phenyl]-3-[4-(2-.. |
A | 56.2 /31.7 |
16 /18 |
NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 | |
7wge[1] | C |
AGS
PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER[31 atom.. |
A | 88.9 /32.7 |
9 /17 |
NLRP1_HUMAN NACHT, LRR and PYD domains-containing protein 1, N.. | |
8ej4[10] | U |
AGS
PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER[31 atom.. |
A | 61.5 /31.7 |
13 /19 |
NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 | |
8ri2[1] | B |
A1H02
2-[4-chloranyl-9-oxidanylidene-12-(2-oxidanylpropa.. |
A | 35.7 /31.6 |
14 /16 |
NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 | |
7pzc[10] | L |
8GI
1-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)-3-[4-(2-o.. |
A | 40.0 /31.5 |
15 /15 |
NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 | |
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue. | |||||||
METAL | |||||||
1130 | pdb_id | contact mol | homologue | ||||
a3 | description | a4 | identity[%]5 | Ncon6 | description | ||
7wge[1] | D |
MG
MAGNESIUM ION[1 atoms] |
A | 100.0 /32.7 |
2 /2 |
NLRP1_HUMAN NACHT, LRR and PYD domains-containing protein 1, N.. | |
8ej4[11] | V |
MG
MAGNESIUM ION[1 atoms] |
A | 66.7 /31.7 |
3 /3 |
NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 | |
8wsm[1] | B |
MG
MAGNESIUM ION[1 atoms] |
A | 0.0 /31.8 |
1 /1 |
NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 | |
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue. | |||||||
HOMO | |||||||
1130 | pdb_id | contact mol | homologue | ||||
a3 | description | a4 | identity[%]5 | Ncon6 | description | ||
5irm[1] | B | G1T469_RABIT Uncharacterized protein[770 aa] | A | 40.0 /34.5 |
10 /23 |
G1T469_RABIT Uncharacterized protein | |
7wbt[2] | B | NLRP9_BOVIN NACHT, LRR and PYD domains-containing protein 9[89.. | A | 16.7 /33.1 |
12 /31 |
NLRP9_BOVIN NACHT, LRR and PYD domains-containing protein 9 | |
7lfh[12] | L | NLRP3_MOUSE NACHT, LRR and PYD domains-containing protein 3[80.. | A | 0.0 /33.2 |
3 /20 |
NLRP3_MOUSE NACHT, LRR and PYD domains-containing protein 3 | |
7vtq[12] | H | NLRP3_MOUSE NACHT, LRR and PYD domains-containing protein 3[78.. | A | 0.0 /33.0 |
2 /17 |
NLRP3_MOUSE NACHT, LRR and PYD domains-containing protein 3 | |
7vtp[2] | B | NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3[79.. | A | 100.0 /32.5 |
1 /5 |
NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 | |
7vtp[6] | C | NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3[79.. | A | 66.7 /32.5 |
3 /7 |
NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 | |
7zgu[6] | B | NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3[80.. | A | 50.0 /32.4 |
2 /8 |
NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 | |
7zgu[6] | C | NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3[80.. | A | 50.0 /32.4 |
2 /8 |
NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 | |
8ej4[10] | B | NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3[85.. | A | 22.2 /31.7 |
9 /17 |
NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 | |
8ej4[10] | J | NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3[85.. | A | 33.3 /31.7 |
6 /18 |
NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 | |
8swf[4] | D | NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3[83.. | A | 0.0 /31.7 |
2 /23 |
NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 | |
8swf[4] | E | NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3[83.. | A | 14.3 /31.7 |
7 /14 |
NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 | |
8swf[4] | B | NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3[83.. | C | 25.0 /31.7 |
4 /18 |
NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 | |
8swf[4] | F | NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3[83.. | C | 20.0 /31.7 |
10 /11 |
NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 | |
8swk[6] | F | NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3[81.. | A | 50.0 /32.0 |
2 /6 |
NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 | |
7pzc[10] | B | NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3[88.. | A | 50.0 /31.5 |
6 /13 |
NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 | |
8h93[2] | D | NALP5_MOUSE NACHT, LRR and PYD domains-containing protein 5[94.. | A | 0.0 /24.6 |
1 /8 |
NALP5_MOUSE NACHT, LRR and PYD domains-containing protein 5 | |
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue. |