Contact Molecules for Homologous Proteins | ||||
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PID | QueryLength | Homolgous Sequence in PDB | UniProt Query | TITLE |
3177148 | 400 | 11 | P00973(OAS1_HUMAN) | RecName: Full=2'-5'-oligoadenylate synthase 1; Short=(2-5')oligo(A) synthase 1; Short=2-5A synthase 1; EC=2.7.7.84 ;AltName: Full=E18/E16;AltName: Full=p46/p42 OAS; |
QUERYSEQ |
MMDLRNTPAKSLDKFIEDYLLPDTCFRMQINHAIDIICGFLKERCFRGSSYPVCVSKVVKGGSSGKGTTLRGRSDADLVVFLSPLTTFQDQLNRRGEFIQEIRRQLEACQRERAFSVKFEVQAPRWGNPRALSFVLSSLQLGEGVEFDVL PAFDALGQLTGGYKPNPQIYVKLIEECTDLQKEGEFSTCFTELQRDFLKQRPTKLKSLIRLVKHWYQNCKKKLGKLPPQYALELLTVYAWERGSMKTHFNTAQGFRTVLELVINYQQLCIYWTKYYDFKNPIIEKYLRRQLTKPRPVILD PADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDGSPVSSWILLAESNSADDETDDPRRYQKYGYIGTHEYPHFSHRPSTLQAASTPQAEEDWTCTIL |
400 | region | name | description |
1-400 | CHAIN | /note="2'-5'-oligoadenylate synthase 1" /id="PRO_0000160259" | |
13-60 | REGION | /note="Interaction with dsRNA" ECO:0007744|PDB:4IG8" | |
200-210 | REGION | /note="Interaction with dsRNA" ECO:0007744|PDB:4IG8" | |
63-63 | BINDING | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" ECO:0007744|PDB:4IG8" | |
75-75 | BINDING | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_note="catalytic" ECO:0007744|PDB:4IG8" | |
77-77 | BINDING | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_note="catalytic" ECO:0007744|PDB:4IG8" | |
148-148 | BINDING | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_note="catalytic" ECO:0007744|PDB:4IG8" | |
210-210 | BINDING | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" | |
213-213 | BINDING | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" ECO:0007744|PDB:4IG8" | |
229-229 | BINDING | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" ECO:0007744|PDB:4IG8" | |
397-397 | LIPID | /note="S-geranylgeranyl cysteine" | |
1-395 | DISORDER | predicted by DISOPRED |
MONOMER | |||||||
400 | |||||||
pdb_id | a1 | identity[%]2 | description | ||||
4ig8 | A | 100.0 | OAS1_HUMAN 2'-5'-oligoadenylate synthase 1 | ||||
1.a1:asym_id for the homologue. 2.identity[%]2:sequence identity between the query and the homologue. |
HETERO | |||||||
400 | pdb_id | contact mol | homologue | ||||
a3 | description | a4 | identity[%]5 | Ncon6 | description | ||
6u7b[1] | D | A0A1X1LKT4_ECOLX bacHORMA_1 domain-containing protein[175 aa] | C | 25.0 /26.8 |
4 /14 |
D7Y2H2_ECOLX E. coli MS115-1 CdnC | |
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue. | |||||||
NUCLEOTIDE | |||||||
400 | pdb_id | contact mol | homologue | ||||
a3 | description | a4 | identity[%]5 | Ncon6 | description | ||
4ig8[1] | B | RNA (5'-R(*GP*GP*CP*UP*UP*UP*UP*GP*AP*CP*CP*UP*UP*.. | A | 100.0 /100.0 |
15 /15 |
OAS1_HUMAN 2'-5'-oligoadenylate synthase 1 | |
4ig8[1] | C | RNA (5'-R(*GP*CP*AP*UP*AP*AP*AP*GP*GP*UP*CP*AP*AP*.. | A | 100.0 /100.0 |
16 /16 |
OAS1_HUMAN 2'-5'-oligoadenylate synthase 1 | |
4rwp[1] | C | RNA (5'-R(*UP*UP*CP*AP*UP*AP*AP*AP*GP*GP*UP*CP*AP*.. | A | 81.8 /75.4 |
22 /22 |
OAS1_PIG 2'-5'-oligoadenylate synthase 1 | |
4rwn[3] | B | RNA (5'-R(*GP*GP*CP*UP*UP*UP*UP*GP*AP*CP*CP*UP*UP*.. | A | 76.5 /75.4 |
17 /17 |
OAS1_PIG 2'-5'-oligoadenylate synthase 1 | |
4s3n[1] | B | RNA (5'-R(*GP*GP*CP*UP*UP*UP*UP*GP*AP*CP*CP*UP*UP*.. | A | 40.0 /47.0 |
10 /10 |
OAS3_HUMAN 2'-5'-oligoadenylate synthase 3 | |
4rwn[2] | C | RNA (5'-R(*UP*UP*CP*AP*UP*AP*AP*AP*GP*GP*UP*CP*AP*.. | A | 84.2 /75.4 |
19 /19 |
OAS1_PIG 2'-5'-oligoadenylate synthase 1 | |
4s3n[1] | C | RNA (5'-R(*UP*UP*CP*AP*UP*AP*AP*AP*GP*GP*UP*CP*AP*.. | A | 46.7 /47.0 |
15 /15 |
OAS3_HUMAN 2'-5'-oligoadenylate synthase 3 | |
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue. | |||||||
COMPOUND | |||||||
400 | pdb_id | contact mol | homologue | ||||
a3 | description | a4 | identity[%]5 | Ncon6 | description | ||
4ig8[1] | F |
DTP
2'-DEOXYADENOSINE 5'-TRIPHOSPHATE [30 atoms] |
A | 100.0 /100.0 |
9 /9 |
OAS1_HUMAN 2'-5'-oligoadenylate synthase 1 | |
4rwn[2] | D |
APC
DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER[31 a.. |
A | 100.0 /75.4 |
13 /13 |
OAS1_PIG 2'-5'-oligoadenylate synthase 1 | |
4rwn[1] | E |
APC
DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER[31 a.. |
A | 100.0 /75.4 |
9 /9 |
OAS1_PIG 2'-5'-oligoadenylate synthase 1 | |
6u7b[1] | K |
AMP
ADENOSINE MONOPHOSPHATE[23 atoms] |
C | 28.6 /26.8 |
14 /14 |
D7Y2H2_ECOLX E. coli MS115-1 CdnC | |
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue. | |||||||
METAL | |||||||
400 | pdb_id | contact mol | homologue | ||||
a3 | description | a4 | identity[%]5 | Ncon6 | description | ||
4ig8[2] | D |
MG
MAGNESIUM ION[1 atoms] |
A | 100.0 /100.0 |
3 /3 |
OAS1_HUMAN 2'-5'-oligoadenylate synthase 1 | |
4rwn[5] | F |
MG
MAGNESIUM ION[1 atoms] |
A | 100.0 /75.4 |
3 /3 |
OAS1_PIG 2'-5'-oligoadenylate synthase 1 | |
6u7b[1] | L |
CL
CHLORIDE ION[1 atoms] |
C | 60.0 /26.8 |
5 /5 |
D7Y2H2_ECOLX E. coli MS115-1 CdnC | |
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue. | |||||||
PRECIPITANT | |||||||
400 | pdb_id | contact mol | homologue | ||||
a3 | description | a4 | identity[%]5 | Ncon6 | description | ||
1px5[2] | C |
SO4
SULFATE ION[5 atoms] |
A | 100.0 /75.5 |
1 /1 |
OAS1_PIG 2'-5'-oligoadenylate synthetase 1 | |
1px5[1] | D |
SO4
SULFATE ION[5 atoms] |
A | 100.0 /75.5 |
3 /3 |
OAS1_PIG 2'-5'-oligoadenylate synthetase 1 | |
1px5[1] | F |
SO4
SULFATE ION[5 atoms] |
B | 0.0 /75.2 |
1 /1 |
OAS1_PIG 2'-5'-oligoadenylate synthetase 1 | |
3.a3:asym_id for the contact molecule. 4.a4:asym_id for the template homologue. 5.identity[%]5:sequence identity between the query and the template homologue only for the contact residues. Number after the slash / is sequence identity for all the aligned region. 6.Ncon6:number of aligned contact residues for the query. Number after the slash / is number of contact residues in the template homologue. |